Identification |
Name: |
Thiamine-phosphate pyrophosphorylase |
Synonyms: |
- TMP pyrophosphorylase
- TMP-PPase
- Thiamine-phosphate synthase
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Gene Name: |
thiE |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in catalytic activity |
Specific Function: |
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) |
Cellular Location: |
Not Available |
KEGG Pathways: |
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KEGG Reactions: |
|
SMPDB Reactions: |
|
4-amino-2-methyl-5-diphosphomethylpyrimidine | + | | + | 2 | + | | → | Thiamine monophosphate | + | | + | diphosphate | + | | + | |
| | | |
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PseudoCyc/BioCyc Reactions: |
| | |
2-[(2R,5Z)-(2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate | + | | + | | → | | + | | + | |
| | | |
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Complex Reactions: |
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Transports: |
Not Available |
Metabolites: |
PAMDB ID | Name | View |
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PAMDB003443 | 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate | MetaboCard | PAMDB000895 | 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate | MetaboCard | PAMDB000942 | 4-Methyl-5-(2-phosphoethyl)-thiazole | MetaboCard | PAMDB000568 | Carbon dioxide | MetaboCard | PAMDB001633 | Hydrogen ion | MetaboCard | PAMDB000633 | Pyrophosphate | MetaboCard | PAMDB000462 | Thiamine monophosphate | MetaboCard |
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GO Classification: |
Function |
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catalytic activity | thiamin-phosphate diphosphorylase activity | transferase activity | transferase activity, transferring alkyl or aryl (other than methyl) groups | Process |
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cellular aromatic compound metabolic process | cellular metabolic process | metabolic process | thiamin and derivative metabolic process | thiamin biosynthetic process | thiamin metabolic process |
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Gene Properties |
Locus tag: |
PA3976 |
Strand: |
+ |
Entrez Gene ID: |
880858 |
Accession: |
NP_252665.1 |
GI: |
15599171 |
Sequence start: |
4456695 |
Sequence End: |
4457324 |
Sequence Length: |
629 |
Gene Sequence: |
>PA3976
ATGAAACTGCGCGGCCTGTACGCCATCACCGATAGCCAGCTACTGGACGACGGCCGCCTGCTGCCCTACGTCGAAGCCGCGCTCCGCGGCGGCGCGCGCCTGCTGCAATACCGCGACAAATCCAGCGACCAGGCGCGGCGCCTGCGCGAGGCGGAAAGCCTGCGCGAACTCTGCGAACGCCACGGCGCGCAGTTGATCGTCAACGACGACGCCGAACTCGCCGCGCGCCTGGGCGTCGGCCTGCACCTCGGCCAGACCGACGGTTCGCTGTCGGCGGCGCGCGCCCTGCTCGGCCGCCAGGCGATCATCGGCGCCACCTGCCACGCCCAACTGGAACTGGCCGAGCAGGCGGTGGCCGAGGGCGCCAGCTACGTCGCCTTCGGCCGCTTCTTCAATTCCAGCACCAAACCCGGCGCCCCCGCCGCCAGCGTCGAACTGCTCGACCAGGCCCGGCCGCGCCTGCACCTGCCGATCACCGCCATCGGCGGCATCAGCCTCGACACCGCGCCCGGCCTGATCGCCCGCGGCGTCGATCTGGTCGCCGTGATCCATGCGCTGTTCGCCGCCGCGTCCGCCGCCGAGGTGGAACGCCGCGCCCGCGCCTTCAGCGCCCTGTTCGAACCTGCCTGA |
Protein Properties |
Protein Residues: |
209 |
Protein Molecular Weight: |
22.1 kDa |
Protein Theoretical pI: |
7.06 |
Hydropathicity (GRAVY score): |
0.076 |
Charge at pH 7 (predicted): |
0.14 |
Protein Sequence: |
>PA3976
MKLRGLYAITDSQLLDDGRLLPYVEAALRGGARLLQYRDKSSDQARRLREAESLRELCERHGAQLIVNDDAELAARLGVGLHLGQTDGSLSAARALLGRQAIIGATCHAQLELAEQAVAEGASYVAFGRFFNSSTKPGAPAASVELLDQARPRLHLPITAIGGISLDTAPGLIARGVDLVAVIHALFAAASAAEVERRARAFSALFEPA |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA3976 and its homologs
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