Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (PA3975)

Identification
Name: Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
Synonyms:
  • Hydroxymethylpyrimidine kinase
  • HMP kinase
  • Hydroxymethylpyrimidine phosphate kinase
  • HMP-P kinase
  • HMP-phosphate kinase
  • HMPP kinase
Gene Name: thiD
Enzyme Class:
Biological Properties
General Function: Involved in phosphomethylpyrimidine kinase activity
Specific Function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
4-Amino-5-hydroxymethyl-2-methylpyrimidine + Adenosine triphosphate ↔ 4-Amino-2-methyl-5-phosphomethylpyrimidine + ADP + Hydrogen ion + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine
ReactionCard
Thumb+Thumb → Thumb+Thumb
4-Amino-2-methyl-5-phosphomethylpyrimidine + Adenosine triphosphate → 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + ADP
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + 4-Amino-5-hydroxymethyl-2-methylpyrimidine ↔ ADP + 4-Amino-2-methyl-5-phosphomethylpyrimidine
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + 4-Amino-2-methyl-5-phosphomethylpyrimidine ↔ ADP + 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
ReactionCard
Thumb+Thumb → Thumb+Thumb
4-Amino-2-methyl-5-phosphomethylpyrimidine + Adenosine triphosphate → 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + ADP
ReactionCard
SMPDB Reactions:
4-amino-2-methyl-5-phosphomethylpyrimidine+Thumb → Thumb+Thumb
4-amino-2-methyl-5-phosphomethylpyrimidine + Adenosine triphosphate → ADP + 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
4-Amino-5-hydroxymethyl-2-methylpyrimidine + Adenosine triphosphate ↔ 4-Amino-2-methyl-5-phosphomethylpyrimidine + ADP + Hydrogen ion + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine
ReactionCard
Thumb+Thumb → Thumb+Thumb
4-Amino-2-methyl-5-phosphomethylpyrimidine + Adenosine triphosphate → 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + ADP
ReactionCard
Thumb+Thumb → Thumb+Thumb
4-Amino-2-methyl-5-phosphomethylpyrimidine + Adenosine triphosphate → 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + ADP
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + 4-Amino-5-hydroxymethyl-2-methylpyrimidine → ADP + 4-Amino-2-methyl-5-phosphomethylpyrimidine
ReactionCard
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + 4-Amino-2-methyl-5-phosphomethylpyrimidine → ADP + 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0008952-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphateMetaboCard
PAMDB0009324-Amino-2-methyl-5-phosphomethylpyrimidineMetaboCard
PAMDB0009344-Amino-5-hydroxymethyl-2-methylpyrimidineMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
GO Classification:
Function
catalytic activity
kinase activity
phosphomethylpyrimidine kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular aromatic compound metabolic process
cellular metabolic process
metabolic process
thiamin and derivative metabolic process
thiamin biosynthetic process
thiamin metabolic process
Gene Properties
Locus tag: PA3975
Strand: +
Entrez Gene ID: 878891
Accession: NP_252664.1
GI: 15599170
Sequence start: 4455887
Sequence End: 4456684
Sequence Length: 797
Gene Sequence: 
>PA3975
ATGAAAACACCGACTTCCCGCCCCGTAGTGCTCTGCCTGTCCGGTCACGACCCCAGTGGTGGCGCCGGACTGCAAGCCGACATCGAAGCCCTGCTCGCCCAGGGCTGCCACGCCGCCCCGGCGGTCACCGCGCTGACCGTGCAGGACACCGTCAACGTCAGCGACTTCCGCGTCCTCGACCGCGAGTGGGTGCTGGCCCAGGCCAACGCCGTACTCGCCGACCTGCCCGTCGCGGCGGTCAAGCTGGGTATGCTCGGTTCGCTGGAGATGGTCGACACGGTGGCCGAGATCCTCGCCGCCCACCCGCACTTGCCGGTGGTCTGCGATCCGGTGCTGCGCGCCGGCGGCGGCGGTGCGCTGGGCAAGGGCGACGTCGGCTTCGCCATGCGCGAGCGGCTACTGCCGCGCGCCACCATCGCCACGCCGAACCTGCCGGAAGCGCGCCTGCTCGCCGACCTGCCCGAGGGCAGCGCCGACCAGTGCGCCGAGCGCCTGCTGGAACACTGCGAGCACCTGTTGATCACCGGCGGACACGGCGACGAAAGCGAAGTGCACAATCGCCTGTACAGCCGCGACGGCAGCCGCCGCACCTTCACCTGCCAGCGCCTGCCCGGCAGCTACCATGGCTCCGGCTGCACCCTGGCCAGCGCCCTGGCCGGTCGCATCGCCCTCGGCGAAGCGCTGCACGGCGCCGTGCAGAGCGCCCTCGACTACACCTGGCGGACCCTGCGCGACGCCGAGAGTCCGGGCCACGGCCAATACGTGCCGCGCCGCCTGCCCACCGACTTCTGTCACTGA
Protein Properties
Protein Residues: 265
Protein Molecular Weight: 28 kDa
Protein Theoretical pI: 6.22
Hydropathicity (GRAVY score): -0.017
Charge at pH 7 (predicted): -5.36
Protein Sequence: 
>PA3975
MKTPTSRPVVLCLSGHDPSGGAGLQADIEALLAQGCHAAPAVTALTVQDTVNVSDFRVLDREWVLAQANAVLADLPVAAVKLGMLGSLEMVDTVAEILAAHPHLPVVCDPVLRAGGGGALGKGDVGFAMRERLLPRATIATPNLPEARLLADLPEGSADQCAERLLEHCEHLLITGGHGDESEVHNRLYSRDGSRRTFTCQRLPGSYHGSGCTLASALAGRIALGEALHGAVQSALDYTWRTLRDAESPGHGQYVPRRLPTDFCH
References
External Links:
Resource Link
Genome ID: PA3975
Entrez Gene ID: 878891
NCBI Protein ID: 15599170
General Reference: PaperBLAST - Find papers about PA3975 and its homologs