Threonine synthase (PA3735)

Identification
Name: Threonine synthase
Synonyms:
  • TS
Gene Name: thrC
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Water + O-Phosphohomoserine ↔ Phosphate + L-Threonine
ReactionCard
Thumb+Thumb → Thumb+Thumb
Water + O-Phospho-4-hydroxy-L-threonine → 4-Hydroxy-L-threonine + Phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
O-Phosphohomoserine + Water ↔ L-Threonine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
O-Phospho-4-hydroxy-L-threonine + Water ↔ 4-Hydroxy-L-threonine + Phosphate
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Thumb+Thumb → Thumb+Thumb
O-Phosphohomoserine + Water → Phosphate + L-Threonine
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SMPDB Reactions:
Thumb+Thumb → Thumb+L-Threonine+Thumb
O-Phosphohomoserine + Water → Phosphate + L-Threonine + L-Threonine
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Water + O-Phosphohomoserine ↔ Phosphate + L-Threonine
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Thumb+Thumb → Thumb+Thumb
O-Phosphohomoserine + Water → Phosphate + L-Threonine
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
O-Phosphohomoserine + Water → L-Threonine + Inorganic phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0009404-Hydroxy-L-threonineMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000068L-ThreonineMetaboCard
PAMDB000691O-Phospho-4-hydroxy-L-threonineMetaboCard
PAMDB000505O-PhosphohomoserineMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
carbon-oxygen lyase activity
carbon-oxygen lyase activity, acting on phosphates
catalytic activity
cofactor binding
lyase activity
pyridoxal phosphate binding
threonine synthase activity
Process
aspartate family amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
threonine biosynthetic process
threonine metabolic process
Gene Properties
Locus tag: PA3735
Strand: -
Entrez Gene ID: 880336
Accession: NP_252424.1
GI: 15598930
Sequence start: 4186781
Sequence End: 4188190
Sequence Length: 1409
Gene Sequence: 
>PA3735
ATGCGTTACATCAGCACCCGCGGCCAAGCGCCCGCCCTGAACTTCGAAGATGTCCTCCTCGCCGGCCTGGCCAGCGACGGCGGCCTCTACGTCCCGGAAAACCTGCCACGCTTCACCCTCGAGGAGATCGCCTCCTGGGTCGGCCTGCCCTACCACGAGCTGGCCTTCCGGGTGATGCGCCCGTTCGTCGCCGGCAGCATCGCCGATGCCGACTTCAAGAAGATCCTCGAGGAAACCTATGGCGTCTTCGCCCATGACGCAGTGGCGCCGCTGCGCCAGTTGAACGGCAACGAATGGGTGCTGGAGCTGTTCCACGGCCCGACCCTGGCCTTCAAGGATTTCGCCCTGCAACTGCTCGGCCGCCTGCTCGACCATGTGCTGGCCAAGCGCGGCGAGCGTGTGGTGATCATGGGGGCCACCTCCGGCGATACCGGCTCCGCGGCCATCGAAGGCTGCCGCCGTTGCGACAACGTCGACATCTTCATCATGCACCCGCACAACCGCGTGTCCGAGGTGCAGCGCCGGCAGATGACCACCATCCTCGGCGACAACATCCACAACATCGCCATCGAAGGCAACTTCGACGACTGCCAGGAGATGGTCAAGGCCAGCTTCGCCGACCAGGGCTTCCTCAAGGGTACCCGCCTGGTAGCGGTGAACTCGATCAACTGGGCGCGGATCATGGCCCAGATCGTCTACTACTTCCATGCCGCGCTGCAGCTCGGCGCGCCGCATCGCTCGGTGGCGTTCTCGGTGCCGACCGGCAACTTCGGCGACATCTTCGCCGGCTACCTGGCGCGCAACATGGGCCTGCCGGTCAGCCAGCTGATCGTCGCGACCAACCGCAACGACATCCTGCACCGCTTCATGAGCGGTAATCGCTACGACAAGGACACCCTGCATCCCTCGCTGTCGCCGTCGATGGATATCATGGTCTCGTCCAACTTCGAACGCCTGCTGTTCGACCTGCACGGCCGCAACGGCAAGGCCGTCGCCGAACTGCTGGATGCCTTCAAGGCCAGCGGCAAGCTGTCGGTGGAAGACCAGCGCTGGACCGAGGCGCGCAAGCTGTTCGACTCCCTGGCGGTCAGCGACGAGCAGACCTGCGAGACCATCGCCGAGGTATACCGCTCCAGTGGCGAGTTGCTCGACCCGCACACCGCCATTGGCGTGCGTGCCGCCCGCGAATGCCGGCGCAGCCTGAGCGTGCCGATGGTGACCCTGGGCACTGCGCATCCGGTCAAGTTCCCCGAAGCGGTGGAGAAGGCCGGCATCGGCCAGGCACCGGCGCTGCCTGCGCACCTCGCCGACCTGTTCGAGCGCGAGGAGCGCTGCACCGTATTGCCGAACGAGCTGGCCAAGGTACAGGCCTTCGTCAGCCAGCACGGCAATCGCGGCAAGCCGCTCTGA
Protein Properties
Protein Residues: 469
Protein Molecular Weight: 51.8 kDa
Protein Theoretical pI: 6.61
Hydropathicity (GRAVY score): -0.079
Charge at pH 7 (predicted): -3.32
Protein Sequence: 
>PA3735
MRYISTRGQAPALNFEDVLLAGLASDGGLYVPENLPRFTLEEIASWVGLPYHELAFRVMRPFVAGSIADADFKKILEETYGVFAHDAVAPLRQLNGNEWVLELFHGPTLAFKDFALQLLGRLLDHVLAKRGERVVIMGATSGDTGSAAIEGCRRCDNVDIFIMHPHNRVSEVQRRQMTTILGDNIHNIAIEGNFDDCQEMVKASFADQGFLKGTRLVAVNSINWARIMAQIVYYFHAALQLGAPHRSVAFSVPTGNFGDIFAGYLARNMGLPVSQLIVATNRNDILHRFMSGNRYDKDTLHPSLSPSMDIMVSSNFERLLFDLHGRNGKAVAELLDAFKASGKLSVEDQRWTEARKLFDSLAVSDEQTCETIAEVYRSSGELLDPHTAIGVRAARECRRSLSVPMVTLGTAHPVKFPEAVEKAGIGQAPALPAHLADLFEREERCTVLPNELAKVQAFVSQHGNRGKPL
References
External Links:
Resource Link
Genome ID: PA3735
Entrez Gene ID: 880336
NCBI Protein ID: 15598930
General Reference: PaperBLAST - Find papers about PA3735 and its homologs