Identification
Name: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms:
  • DXP reductoisomerase
  • 1-deoxyxylulose-5-phosphate reductoisomerase
  • 2-C-methyl-D-erythritol 4-phosphate synthase
Gene Name: dxr
Enzyme Class:
Biological Properties
General Function: Involved in 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Specific Function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb+Thumb
SMPDB Reactions:
NADPH+Thumb+1-Deoxy-D-xylulose 5-phosphate+Thumb+ThumbThumb+2-C-methyl-D-erythritol 4-phosphate
NADPH + Hydrogen ion + 1-Deoxy-D-xylulose 5-phosphate + NADPH + 1-Deoxy-D-xylulose 5-phosphateNADP + 2-C-methyl-D-erythritol 4-phosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb+Thumb
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0003011-Deoxy-D-xylulose 5-phosphateMetaboCard
PAMDB0006122-C-Methyl-D-erythritol-4-phosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
GO Classification:
Function
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
binding
catalytic activity
cation binding
ion binding
metal ion binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
cellular lipid metabolic process
isoprenoid biosynthetic process
isoprenoid metabolic process
lipid metabolic process
metabolic process
oxidation reduction
primary metabolic process
Gene Properties
Locus tag: PA3650
Strand: -
Entrez Gene ID: 880464
Accession: NP_252340.1
GI: 15598846
Sequence start: 4088904
Sequence End: 4090094
Sequence Length: 1190
Gene Sequence:
>PA3650
ATGAGTCGACCGCAGCGGATCAGCGTGCTCGGCGCGACCGGCTCGATCGGCCTGAGCACCCTGGACGTCGTCCAGCGTCATCCCGATCGTTACGAAGCCTTCGCCCTGACTGGCTTCAGCCGCCTGGCCGAACTCGAGGCGCTGTGCCTCAGGCACCGCCCCGTCTATGCGGTGGTGCCGGAGCAGGCCGCGGCGATTGCCTTGCAGGGCTCGCTCGCCGCGGCGGGTATCCGCACCCGGGTGCTGTTCGGCGAGCAGGCGTTGTGCGAAGTGGCCAGCGCGCCCGAAGTGGACATGGTAATGGCGGCCATCGTCGGCGCCGCCGGGCTGCCGTCGACCCTGGCGGCCGTCGAGGCCGGCAAGCGCGTACTGCTGGCCAACAAGGAGGCGCTGGTGATGTCCGGCGCGCTGTTCATGCAGGCGGTCAAGCGCAGCGGCGCGGTGCTCCTGCCGATCGACAGCGAGCACAACGCGATCTTCCAGTCGCTGCCGCGCAATTATGCCGATGGCCTGGAGCGGGTCGGCGTGCGCCGGATCCTCTTGACCGCCTCCGGCGGCCCGTTCCGCGAGACGCCGCTGGAGCAACTCGCTTCGGTGACGCCGGAGCAGGCTTGTGCGCACCCGAACTGGTCGATGGGGCGTAAGATTTCCGTCGACTCCGCCAGCATGATGAACAAGGGGCTCGAACTGATCGAGGCGTGCTGGCTGTTCGACGCCCAGCCGAGCCAGGTCGAGGTGGTGATCCACCCGCAGAGCGTGATCCACTCGATGGTGGACTACGTCGACGGTTCGGTGATCGCCCAGCTCGGCAATCCGGACATGCGCACGCCGATTTCCTATGCCATGGCCTGGCCGGAGCGAATCGATTCCGGCGTTTCGCCGCTGGATATGTTCGCCGTCGGTCGCCTGGATTTCCAGCGCCCCGACGAGCAGCGCTTCCCCTGCCTGCGCCTGGCGAGCCAGGCCGCGGAAACCGGCGGCAGCGCCCCGGCCATGCTGAATGCCGCGAACGAGGTGGCCGTGGCCGCATTTCTCGAGCGGCACATCCGCTTCAGCGACATCGCGGTTATCATCGAGGACGTGCTGAACCGCGAGGCGGTGACCGCAGTCGAATCGCTCGATCAGGTCCTGGCTGCCGATCGCCGCGCGCGTTCGGTCGCCGGGCAATGGTTGACCCGGCACGCCGGCTAG
Protein Properties
Protein Residues: 396
Protein Molecular Weight: 42.5 kDa
Protein Theoretical pI: 5.65
Hydropathicity (GRAVY score): 0.147
Charge at pH 7 (predicted): -6.21
Protein Sequence:
>PA3650
MSRPQRISVLGATGSIGLSTLDVVQRHPDRYEAFALTGFSRLAELEALCLRHRPVYAVVPEQAAAIALQGSLAAAGIRTRVLFGEQALCEVASAPEVDMVMAAIVGAAGLPSTLAAVEAGKRVLLANKEALVMSGALFMQAVKRSGAVLLPIDSEHNAIFQSLPRNYADGLERVGVRRILLTASGGPFRETPLEQLASVTPEQACAHPNWSMGRKISVDSASMMNKGLELIEACWLFDAQPSQVEVVIHPQSVIHSMVDYVDGSVIAQLGNPDMRTPISYAMAWPERIDSGVSPLDMFAVGRLDFQRPDEQRFPCLRLASQAAETGGSAPAMLNAANEVAVAAFLERHIRFSDIAVIIEDVLNREAVTAVESLDQVLAADRRARSVAGQWLTRHAG
References
External Links:
Resource Link
Genome ID: PA3650
Entrez Gene ID: 880464
NCBI Protein ID: 15598846
General Reference: PaperBLAST - Find papers about PA3650 and its homologs