D-serine dehydratase (PA3357)

Identification
Name: D-serine dehydratase
Synonyms:
  • D-serine deaminase
  • DSD
Gene Name: dsdA
Enzyme Class:
Biological Properties
General Function: Involved in D-serine ammonia-lyase activity
Specific Function: D-serine = pyruvate + NH(3)
Cellular Location: Not Available
KEGG Pathways:
  • Glycine, serine and threonine metabolism pae00260
KEGG Reactions:
Thumb ↔ Thumb+Thumb
D-Serine ↔ Pyruvic acid + Ammonia
ReactionCard
Thumb → Thumb+Thumb+Thumb
D-Serine → Hydrogen ion + Pyruvic acid + Ammonia
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Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb
D-Serine + 2-Aminoacrylic acid + 2-Iminopropanoate + Water ↔ Pyruvic acid + Ammonia
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SMPDB Reactions:
Thumb → Thumb+Thumb+Thumb
D-Serine → Water + Hydrogen ion + 2-Aminoacrylic acid
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PseudoCyc/BioCyc Reactions:
Thumb → Thumb+Thumb+Thumb
D-Serine → Hydrogen ion + Pyruvic acid + Ammonia
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
D-Serine → Ammonium + Pyruvic acid
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Thumb → Thumb+Thumb
D-Serine → Pyruvic acid + Ammonia
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0005192-Aminoacrylic acidMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB000497D-SerineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
ammonia-lyase activity
binding
carbon-nitrogen lyase activity
catalytic activity
cofactor binding
D-serine ammonia-lyase activity
lyase activity
pyridoxal phosphate binding
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
D-amino acid metabolic process
metabolic process
Gene Properties
Locus tag: PA3357
Strand: +
Entrez Gene ID: 882524
Accession: NP_252047.1
GI: 15598553
Sequence start: 3768184
Sequence End: 3769530
Sequence Length: 1346
Gene Sequence: 
>PA3357
TTGATTCTCGGAACACCCAAGGCCGACTGGCTCGCCGAATTCCCGCGCCTGGCCGACCTCATCGCCCTGCGTCCGAGCGAGTGGTTCAACCCGGCCATCGCGCCGAGCGCCGAAGCCCTGGCCGACGTCGGCCTCGGCGCCGCCGACGTGGCCGACGCCAGCGCCCGCCTGCAGCGCTTCGCCCCGCTGATCGCCCGGCTGTTTCCGGAAACCGCCGCCAGCGGCGGCATCATCGAGTCCGACCTGGTCGAGGTCGCCACCTTCCACGATGCCCTGCGCCAGCATTACGCCGCCGAACTGCCCGGCCGGCTCTGGCTGAAACGCGATAGCCACCTGCCGATCTCCGGCTCGATCAAGGCCCGCGGCGGCATCTATGAAGTGCTCGCCCATGCCGAGCGCCTGGCCCTGGAGCACGGCCTGGTCGGCCTCGACGACGACTACTCGCGGCTGGCCGAGGCGGATTGCCGGGCATTCTTCGCCCGCCACCGGATAGCGGTGGGCTCCACCGGCAACCTGGGCCTTTCCATCGGCATCATCGGCGCCGCGCTGGGCTTCCAGGCCAGCGTGCACATGTCCGCCGACGCCCGCCAGTGGAAGAAGGACAAGCTGCGCGCCCACGGCGTGACGGTGGTGGAGTACGCCTCCGACTACAGTGTCGCGGTGGAACAGGGCCGCCGCGAAGCGGCCGGCGATCCCTACACCCATTTCGTCGACGACGAAAACTCCCGCGACCTGTTCCTCGGCTACGCCGTCGCCGCCGAGCGACTGCGCGGCCAGTTGGACGCCGCCGGCATCCGCGTCGACAGCGAGCACCCGCTGTTCGTCCATCTGCCCTGCGGGGTCGGCGGCGGTCCCGGCGGGGTGGCCTTCGGCCTCAAGCTGGCGTTCGGCGACGCGGTGCACTGCCTGTTCGCCGAGCCGACCCATTCGCCCTGCATGTTCCTCGGCGTCTATACCGGCCGCCACGAGCAGGTTTCGGTGCAGGACTTCGGCATCGACAACCGCACCGCCGCCGATGGCCTGGCGGTGGGGCGTCCGTCGGGCTTCGTCGGCCGCGCCATGCAGCGCCTGCTCGACGGCTACTACACGGTGGACGACGACGAGTTGTTCCGCCTGCTCGCCTTGCTCGAGCGCAGCCAGGGCATCCGCCTGGAACCCTCGGCCCTGGCCGGCGCGACGGGCATCGCCCGGGTCACCCGTGAGCCGCAGGGCTATCGCGAACGCATGGGGCTGACCTCGGCGCGCCTGGCCAATGCTACCCACCTGGTCTGGGCCACCGGCGGCGGCATGGTGCCCGAGACGGAAATGCGCGCCTACCTGGAGCGAGGCCGCTCGCTGCTGGACTGA
Protein Properties
Protein Residues: 448
Protein Molecular Weight: 48.2 kDa
Protein Theoretical pI: 5.99
Hydropathicity (GRAVY score): -0.034
Charge at pH 7 (predicted): -8.5
Protein Sequence: 
>PA3357
MILGTPKADWLAEFPRLADLIALRPSEWFNPAIAPSAEALADVGLGAADVADASARLQRFAPLIARLFPETAASGGIIESDLVEVATFHDALRQHYAAELPGRLWLKRDSHLPISGSIKARGGIYEVLAHAERLALEHGLVGLDDDYSRLAEADCRAFFARHRIAVGSTGNLGLSIGIIGAALGFQASVHMSADARQWKKDKLRAHGVTVVEYASDYSVAVEQGRREAAGDPYTHFVDDENSRDLFLGYAVAAERLRGQLDAAGIRVDSEHPLFVHLPCGVGGGPGGVAFGLKLAFGDAVHCLFAEPTHSPCMFLGVYTGRHEQVSVQDFGIDNRTAADGLAVGRPSGFVGRAMQRLLDGYYTVDDDELFRLLALLERSQGIRLEPSALAGATGIARVTREPQGYRERMGLTSARLANATHLVWATGGGMVPETEMRAYLERGRSLLD
References
External Links:
Resource Link
Genome ID: PA3357
Entrez Gene ID: 882524
NCBI Protein ID: 15598553
General Reference: PaperBLAST - Find papers about PA3357 and its homologs