Glucose-6-phosphate 1-dehydrogenase (PA3183)

Identification
Name: Glucose-6-phosphate 1-dehydrogenase
Synonyms:
  • G6PD
Gene Name: zwf
Enzyme Class:
Biological Properties
General Function: Involved in glucose-6-phosphate dehydrogenase activity
Specific Function: D-glucose 6-phosphate + NADP(+) = D-glucono- 1,5-lactone 6-phosphate + NADPH
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
beta-D-Glucose 6-phosphate + NADP ↔ 6-Phosphonoglucono-D-lactone + NADPH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Glucose 6-phosphate + NADP ↔ 6-Phosphonoglucono-D-lactone + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+NADPH+Thumb+Thumb
beta-D-Glucose 6-phosphate + NADP → 6-Phosphonoglucono-D-lactone + NADPH + Hydrogen ion + NADPH
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Glucose 6-phosphate + NADP ↔ 6-Phosphonoglucono-D-lactone + Hydrogen ion + NADPH
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Glucose 6-phosphate + NADP ↔ 6-Phosphonoglucono-D-lactone + NADPH + Hydrogen ion
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Glucose 6-phosphate + NADP → 6-Phosphonoglucono-D-lactone + NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0002646-Phosphonoglucono-D-lactoneMetaboCard
PAMDB000506beta-D-Glucose 6-phosphateMetaboCard
PAMDB000372Glucose 6-phosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
GO Classification:
Function
binding
catalytic activity
glucose-6-phosphate dehydrogenase activity
NADP or NADPH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
alcohol metabolic process
glucose metabolic process
hexose metabolic process
metabolic process
monosaccharide metabolic process
oxidation reduction
small molecule metabolic process
Gene Properties
Locus tag: PA3183
Strand: -
Entrez Gene ID: 882681
Accession: NP_251873.1
GI: 15598379
Sequence start: 3572324
Sequence End: 3573793
Sequence Length: 1469
Gene Sequence: 
>PA3183
ATGCCTGATGTCCGCGTTCTGCCTTGCACGTTAGCGCTGTTCGGTGCGCTGGGCGATCTCGCCTTGCGCAAGCTGTTCCCGGCGCTCTACCAACTCGATCGTGAGAACCTGCTGCACCGCGATACCCGCGTCCTGGCCCTGGCCCGTGACGAAGGCGCTCCCGCCGAACACCTGGCGACGCTGGAGCAGCGCCTGCGCCTGGCAGTGCCGGCGAAGGAGTGGGACGACGTGGTCTGGCAGCGTTTCCGCGAACGCCTCGACTACCTGAGCATGGACTTCCTCGACCCGCAGGCCTATGTCGGCTTGCGCGAGGCGGTGGATGACGAACTGCCGCTGGTCGCCTACTTCGCCACGCCGGCCTCGGTGTTCGGCGGCATCTGCGAGAACCTCGCCGCCGCCGGTCTCGCCGAGCGCACCCGGGTGGTGCTGGAGAAGCCCATCGGTCATGACCTGGAGTCGTCCCGCGAGGTCAACGAGGCAGTCGCCCGGTTCTTCCCGGAAAGCCGCATCTACCGGATCGACCATTACCTGGGCAAGGAGACGGTGCAGAACCTGATCGCCCTGCGCTTCGCCAACAGCCTCTTCGAGACCCAGTGGAACCAGAACCACATCTCCCACGTGGAGATCACCGTGGCCGAGAAGGTCGGCATCGAAGGCCGCTGGGGCTACTTCGACCAGGCCGGGCAACTGCGCGACATGGTGCAGAACCACCTGCTGCAACTGCTCTGCCTGATCGCCATGGATCCGCCCAGCGACCTTTCGGCGGACAGCATTCGCGACGAGAAGGTCAAGGTCCTCCGCGCCCTCGAGCCGATTCCCGCAGAACAACTGGCTTCGCGCGTGGTGCGTGGGCAGTACACCGCCGGTTTCAGCGACGGCAAGGCAGTGCCGGGCTACCTGGAGGAGGAACATGCGAATCGCGACAGCGACGCGGAAACCTTCGTCGCCCTGCGCGTGGACATCCGCAACTGGCGCTGGTCGGGCGTGCCGTTCTACCTGCGCACCGGCAAGCGCATGCCGCAGAAGCTGTCGCAGATCGTCATCCACTTCAAGGAGCCGCCGCACTACATCTTCGCTCCCGAGCAGCGTTCGCTGATCAGCAACCGGCTGATCATCCGCCTGCAGCCGGACGAAGGTATCTCCCTGCAAGTGATGACCAAGGACCAGGGCCTGGGCAAGGGCATGCAATTGCGTACCGGCCCGCTGCAACTGAGTTTTTCCGAGACCTACCACGCGGCGCGGATTCCCGATGCCTACGAGCGTCTGCTGCTGGAGGTCACCCAGGGCAACCAGTACCTGTTCGTGCGCAAGGACGAGGTGGAGTTCGCCTGGAAGTGGTGCGACCAGCTGATCGCTGGCTGGGAACGCCTGAGCGAAGCGCCCAAGCCGTATCCGGCGGGGAGTTGGGGGCCGGTGGCCTCGGTGGCCCTGGTGGCCCGCGATGGGAGGAGTTGGTATGGCGATTTCTGA
Protein Properties
Protein Residues: 489
Protein Molecular Weight: 55.6 kDa
Protein Theoretical pI: 5.68
Hydropathicity (GRAVY score): -0.262
Charge at pH 7 (predicted): -8.45
Protein Sequence: 
>PA3183
MPDVRVLPCTLALFGALGDLALRKLFPALYQLDRENLLHRDTRVLALARDEGAPAEHLATLEQRLRLAVPAKEWDDVVWQRFRERLDYLSMDFLDPQAYVGLREAVDDELPLVAYFATPASVFGGICENLAAAGLAERTRVVLEKPIGHDLESSREVNEAVARFFPESRIYRIDHYLGKETVQNLIALRFANSLFETQWNQNHISHVEITVAEKVGIEGRWGYFDQAGQLRDMVQNHLLQLLCLIAMDPPSDLSADSIRDEKVKVLRALEPIPAEQLASRVVRGQYTAGFSDGKAVPGYLEEEHANRDSDAETFVALRVDIRNWRWSGVPFYLRTGKRMPQKLSQIVIHFKEPPHYIFAPEQRSLISNRLIIRLQPDEGISLQVMTKDQGLGKGMQLRTGPLQLSFSETYHAARIPDAYERLLLEVTQGNQYLFVRKDEVEFAWKWCDQLIAGWERLSEAPKPYPAGSWGPVASVALVARDGRSWYGDF
References
External Links:
Resource Link
Genome ID: PA3183
Entrez Gene ID: 882681
NCBI Protein ID: 15598379
General Reference: PaperBLAST - Find papers about PA3183 and its homologs