Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (PA3112)

Identification
Name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Synonyms:
  • ACCase subunit beta
  • Acetyl-CoA carboxylase carboxyltransferase subunit beta
Gene Name: accD
Enzyme Class:
Biological Properties
General Function: Involved in acetyl-CoA carboxylase activity
Specific Function: Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate ↔ ADP + Hydrogen ion + Malonyl-CoA + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + Acetyl-CoA + Hydrogen carbonate ↔ ADP + Phosphate + Malonyl-CoA
ReactionCard
Thumb+Carboxybiotin-carboxyl-carrier protein ↔ Thumb+Holo-[carboxylase]
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein ↔ Malonyl-CoA + Holo-[carboxylase]
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb+Malonyl-CoA+Thumb+Thumb
Acetyl-CoA + Hydrogen carbonate + Adenosine triphosphate → Adenosine diphosphate + Phosphate + Hydrogen ion + Malonyl-CoA + ADP + Malonyl-CoA
ReactionCard
a biotinylated [BCCP dimer]+Thumb+Thumb → carboxylated-biotinylated [BCCP dimer]+Thumb+Thumb+Thumb
a biotinylated [BCCP dimer] + Adenosine triphosphate + Hydrogen carbonate → carboxylated-biotinylated [BCCP dimer] + Hydrogen ion + ADP + Phosphate
ReactionCard
a biotinylated [BCCP dimer]+Thumb+Thumb+Thumb+Thumb ← Thumb+Thumb+Thumb+carboxylated-biotinylated [BCCP dimer]
a biotinylated [BCCP dimer] + Hydrogen ion + Phosphate + ADP + Malonyl-CoA ← Water + Acetyl-CoA + Adenosine triphosphate + carboxylated-biotinylated [BCCP dimer]
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate ↔ ADP + Hydrogen ion + Malonyl-CoA + Phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Inorganic phosphate + Malonyl-CoA
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000298Acetyl-CoAMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000510Carbonic acidMetaboCard
PAMDB000153Hydrogen carbonateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000284Malonyl-CoAMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
acetyl-CoA carboxylase complex
macromolecular complex
protein complex
Function
acetyl-CoA carboxylase activity
catalytic activity
CoA carboxylase activity
ligase activity
ligase activity, forming carbon-carbon bonds
Process
carboxylic acid metabolic process
cellular metabolic process
fatty acid biosynthetic process
fatty acid metabolic process
metabolic process
monocarboxylic acid metabolic process
organic acid metabolic process
oxoacid metabolic process
Gene Properties
Locus tag: PA3112
Strand: -
Entrez Gene ID: 877680
Accession: NP_251802.1
GI: 15598308
Sequence start: 3492701
Sequence End: 3493573
Sequence Length: 872
Gene Sequence: 
>PA3112
ATGAGCAACTGGCTGGTAGACAAGCTGATCCCTTCCATCATGCGTTCCGAGTCCCAGAAGAGTTCGGTACCGGAAGGCCTGTGGCACAAATGCCCGTCCTGCGAAGCCGTGCTGTACCGTCCGGAGCTGGAAAAGACCCTGGATGTCTGCCCGAAGTGCGATCACCACATGCGCATCAACGCGCGTACCCGCCTGGATATCTTCCTCGATGAGGACGGTCGCGAGGAGCTGGGCGCCGACCTCGAGCCGGTGGACCGCCTGAAATTCCGCGACAGCAAGAAGTACAAGGATCGCCTCGCCGCGGCACAGAAGGACACCGGCGAGAAGGACGCGCTGATCGCCATGAGCGGCAAGCTGCAGGGCATGCCGGTGGTCGCCTGCGCCTTCGAGTTCTCCTTCATGGGCGGTTCGATGGGCGCCATCGTCGGCGAGCGCTTCGTTCGCGCAGCCAACGTCGCCCTTGAGAAGCGCTGCCCGCTGATCTGCTTCTCCGCCTCCGGCGGCGCGCGCATGCAGGAAGCGCTGATCTCGCTGATGCAGATGGCCAAGACCTCGGCGGTTCTGGCGCGCCTGCGCGAAGAAGGCATCCCGTTCGTCTCGGTATTGACCGACCCGGTCTACGGCGGCGTTTCCGCCAGCCTGGCGATGCTCGGCGACGTGATCGTCGGCGAACCCAAGGCGCTGATCGGCTTCGCCGGTCCTCGCGTGATCGAGCAGACCGTCCGCGAGAAGCTTCCGGAAGGCTTCCAGCGTAGCGAGTTCCTCCTTGAGCATGGCGCCATCGACATGATCGTGCATCGTGCCGAGTTGCGGCCGCGCCTGGCCAATCTGCTGTCGGCCTTCACTCATTCGCCGAGCCCCGTATCCGCATGA
Protein Properties
Protein Residues: 290
Protein Molecular Weight: 31.8 kDa
Protein Theoretical pI: 7.08
Hydropathicity (GRAVY score): -0.053
Charge at pH 7 (predicted): 0.24
Protein Sequence: 
>PA3112
MSNWLVDKLIPSIMRSESQKSSVPEGLWHKCPSCEAVLYRPELEKTLDVCPKCDHHMRINARTRLDIFLDEDGREELGADLEPVDRLKFRDSKKYKDRLAAAQKDTGEKDALIAMSGKLQGMPVVACAFEFSFMGGSMGAIVGERFVRAANVALEKRCPLICFSASGGARMQEALISLMQMAKTSAVLARLREEGIPFVSVLTDPVYGGVSASLAMLGDVIVGEPKALIGFAGPRVIEQTVREKLPEGFQRSEFLLEHGAIDMIVHRAELRPRLANLLSAFTHSPSPVSA
References
External Links:
Resource Link
Genome ID: PA3112
Entrez Gene ID: 877680
NCBI Protein ID: 15598308
General Reference: PaperBLAST - Find papers about PA3112 and its homologs