6-carboxy-5,6,7,8-tetrahydropterin synthase (PA2666)

Identification
Name: 6-carboxy-5,6,7,8-tetrahydropterin synthase
Synonyms:
  • CPH4 synthase
  • Queuosine biosynthesis protein queD
Gene Name: queD
Enzyme Class:
Biological Properties
General Function: Coenzyme transport and metabolism
Specific Function: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
Dihydroneopterin triphosphate ↔ Dyspropterin + Triphosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Triphosphate+2 Thumb+Thumb+Thumb
7,8-dihydroneopterin 3'-triphosphate + Water → Acetaldehyde + Triphosphate + 2 Hydrogen ion + 6-Carboxy-5,6,7,8-tetrahydropterin + Triphosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Dihydroneopterin triphosphate + Water → Acetaldehyde + 6-Carboxy-5,6,7,8-tetrahydropterin + Hydrogen ion + Triphosphate
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Dihydroneopterin triphosphate + Water → Hydrogen ion + 6-Carboxy-5,6,7,8-tetrahydropterin + Triphosphate + Acetaldehyde
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Dihydroneopterin triphosphate + Water → 6-Carboxy-5,6,7,8-tetrahydropterin + Acetaldehyde + Triphosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015896-Carboxy-5,6,7,8-tetrahydropterinMetaboCard
PAMDB0063627,8-dihydroneopterin 3'-triphosphateMetaboCard
PAMDB000217AcetaldehydeMetaboCard
PAMDB000274Dihydroneopterin triphosphateMetaboCard
PAMDB000292DyspropterinMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000496TriphosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
6-pyruvoyltetrahydropterin synthase activity
binding
carbon-oxygen lyase activity
carbon-oxygen lyase activity, acting on phosphates
catalytic activity
cation binding
ion binding
lyase activity
metal ion binding
Process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
metabolic process
pteridine and derivative biosynthetic process
tetrahydrobiopterin biosynthetic process
Gene Properties
Locus tag: PA2666
Strand: +
Entrez Gene ID: 882375
Accession: NP_251356.1
GI: 15597862
Sequence start: 3015582
Sequence End: 3015938
Sequence Length: 356
Gene Sequence: 
>PA2666
GTGGAACTCTTCAAAGAATTCACCTTCGAATCCGCCCATCGCCTGCCCCACGTCCCCGAAGGCCACAAATGCGGGCGCCTGCACGGCCACTCGTTCCGTGTCGCCATCCACATCGAAGGCGAGGTCGATCCGCATACCGGCTGGATCCGCGACTTCGCGGAAATCAAGGCGATCTTCAAGCCGATCTACGAGCAACTCGACCACAATTATCTGAACGATATTCCAGGCCTGGAAAACCCCACCAGCGAAAACCTCTGCCGCTGGATCTGGCAACAACTCAAGCCGCTGTTGCCGGAACTCTCCAAGGTCCGCGTCCACGAAACTTGCACCAGCGGTTGCGAATATCGGGGCGATTGA
Protein Properties
Protein Residues: 118
Protein Molecular Weight: 13.8 kDa
Protein Theoretical pI: 6.41
Hydropathicity (GRAVY score): -0.545
Charge at pH 7 (predicted): -2.97
Protein Sequence: 
>PA2666
MELFKEFTFESAHRLPHVPEGHKCGRLHGHSFRVAIHIEGEVDPHTGWIRDFAEIKAIFKPIYEQLDHNYLNDIPGLENPTSENLCRWIWQQLKPLLPELSKVRVHETCTSGCEYRGD
References
External Links:
Resource Link
Genome ID: PA2666
Entrez Gene ID: 882375
NCBI Protein ID: 15597862
General Reference: PaperBLAST - Find papers about PA2666 and its homologs