Thioredoxin reductase (PA2616)

Identification
Name: Thioredoxin reductase
Synonyms:
  • TRXR
Gene Name: trxB
Enzyme Class:
Biological Properties
General Function: Involved in oxidation-reduction process
Specific Function: Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thioredoxin+Thumb+Thumb ↔ Thioredoxin disulfide+Thumb+Thumb+Thioredoxin disulfide
Thioredoxin + NADP + Thioredoxin ↔ Thioredoxin disulfide + NADPH + Hydrogen ion + Thioredoxin disulfide
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Thumb+3 Thumb+3 Thumb ↔ Thumb+3 Thumb+5 Thumb
Hydrogen selenide + 3 NADP + 3 Water ↔ Selenite + 3 NADPH + 5 Hydrogen ion
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2 Thumb+2 Thumb+Methylselenic acid ↔ 2 Thumb+2 Thumb+Methaneselenol
2 NADPH + 2 Hydrogen ion + Methylselenic acid ↔ 2 NADP + 2 Water + Methaneselenol
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SMPDB Reactions:
oxidized thioredoxin +Thumb+Thumb → reduced thioredoxin+Thumb
oxidized thioredoxin + NADPH + Hydrogen ion → reduced thioredoxin + NADP
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PseudoCyc/BioCyc Reactions:
Thioredoxin+Thumb+Thumb ↔ Thioredoxin disulfide+Thumb+Thumb+Thioredoxin disulfide
Thioredoxin + NADP + Thioredoxin ↔ Thioredoxin disulfide + NADPH + Hydrogen ion + Thioredoxin disulfide
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Thumb+3 Thumb+3 Thumb ↔ Thumb+3 Thumb+5 Thumb
Hydrogen selenide + 3 NADP + 3 Water ↔ Selenite + 3 NADPH + 5 Hydrogen ion
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2 Thumb+2 Thumb+Methylselenic acid ↔ 2 Thumb+2 Thumb+Methaneselenol
2 NADPH + 2 Hydrogen ion + Methylselenic acid ↔ 2 NADP + 2 Water + Methaneselenol
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Thioredoxin+Thumb → thioredoxin disulfide+Thumb
Thioredoxin + NADP → thioredoxin disulfide + NADPH
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Thumb
a reduced thioredoxin + NADP+ ← an oxidized thioredoxin + NADPH + H+
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Complex Reactions:
Thumb+Thumb+Oxidized Thioredoxin → Thumb+Reduced Thioredoxin
Hydrogen ion + NADPH + Oxidized Thioredoxin → NADP + Reduced Thioredoxin
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Thioredoxin+Thumb → thioredoxin disulfide+Thumb
Thioredoxin + NADP → thioredoxin disulfide + NADPH
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001633Hydrogen ionMetaboCard
PAMDB000804Hydrogen selenideMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB001752SeleniteMetaboCard
PAMDB004174ThioredoxinMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenyl nucleotide binding
antioxidant activity
binding
catalytic activity
FAD or FADH2 binding
nucleoside binding
oxidoreductase activity
purine nucleoside binding
thioredoxin-disulfide reductase activity
Process
cellular metabolic process
metabolic process
oxidation reduction
oxygen and reactive oxygen species metabolic process
removal of superoxide radicals
superoxide metabolic process
Gene Properties
Locus tag: PA2616
Strand: +
Entrez Gene ID: 882322
Accession: NP_251306.1
GI: 15597812
Sequence start: 2959468
Sequence End: 2960418
Sequence Length: 950
Gene Sequence: 
>PA2616
ATGAGTGAAGTCAAGCATTCGCGCCTCATCATCCTGGGCTCCGGTCCGGCCGGCTATACCGCCGCCGTGTACGCCGCACGCGCCAATCTCAAGCCAGTGGTGATCACCGGCATCCAGCCAGGCGGCCAGCTGACCACCACCACCGAAGTCGACAACTGGCCGGGCGACGTCGAAGGCCTTACCGGCCCGGCGCTGATGACCCGCATGCAGCAGCACGCCGAGCGTTTCGACACCGAGATCGTCTACGACCACATCCACACCGCCGAGTTGCAACAGCGCCCCTTCACACTGAAGGGCGATAGTGGCACTTATACCTGCGATGCATTGATCATTGCCACCGGTGCCTCCGCGCAATACCTGGGCATGTCATCGGAAGAAGCCTTCATGGGCAAGGGCGTTTCCGCCTGCGCCACCTGCGACGGCTTCTTCTACCGCAACCAGGTGGTCTGCGTAGTCGGCGGCGGCAATACCGCCGTCGAGGAAGCGCTGTATCTGGCCAACATCGCCAAGGAAGTCCACCTGATCCACCGTCGCGACAAGCTGCGCTCGGAGAAGATCCTCCAGGACAAGCTGTTCGACAAGGCCGAGAACGGCAACGTGCACCTGCACTGGAACACCACCCTGGACGAGGTGCTGGGCGACGCCAGCGGCGTCACCGGCGTACGCCTGAAGAGCACCATCGACGGCAGCACCAGCGAGCTATCGCTGGCCGGCGTGTTCATCGCCATCGGCCACAAGCCGAACACCGACCTGTTCCAGGGCCAACTGGAAATGCGCGACGGCTACCTGCGGATCCACGGCGGCAGCGAAGGCAATGCCACCCAGACCAGCATCGAAGGCGTGTTCGCCGCCGGCGACGTGGCCGACCACGTCTACCGCCAGGCCATCACTTCCGCCGGCGCCGGCTGCATGGCCGCGCTGGATGCCGAAAAATACCTCGACGACCATTGA
Protein Properties
Protein Residues: 316
Protein Molecular Weight: 33.8 kDa
Protein Theoretical pI: 5.17
Hydropathicity (GRAVY score): -0.152
Charge at pH 7 (predicted): -11.26
Protein Sequence: 
>PA2616
MSEVKHSRLIILGSGPAGYTAAVYAARANLKPVVITGIQPGGQLTTTTEVDNWPGDVEGLTGPALMTRMQQHAERFDTEIVYDHIHTAELQQRPFTLKGDSGTYTCDALIIATGASAQYLGMSSEEAFMGKGVSACATCDGFFYRNQVVCVVGGGNTAVEEALYLANIAKEVHLIHRRDKLRSEKILQDKLFDKAENGNVHLHWNTTLDEVLGDASGVTGVRLKSTIDGSTSELSLAGVFIAIGHKPNTDLFQGQLEMRDGYLRIHGGSEGNATQTSIEGVFAAGDVADHVYRQAITSAGAGCMAALDAEKYLDDH
References
External Links:
Resource Link
Genome ID: PA2616
Entrez Gene ID: 882322
NCBI Protein ID: 15597812
General Reference: PaperBLAST - Find papers about PA2616 and its homologs