L-serine dehydratase 1 (PA2443)

Identification
Name: L-serine dehydratase 1
Synonyms:
  • SDH 1
  • L-serine deaminase 1
  • L-SD1
Gene Name: sdaA
Enzyme Class:
Biological Properties
General Function: Involved in L-serine ammonia-lyase activity
Specific Function: Deaminates also threonine, particularly when it is present in high concentration
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
L-Serine ↔ Pyruvic acid + Ammonia
ReactionCard
Thumb ↔ Thumb+Thumb
L-Serine ↔ 2-Aminoacrylic acid + Water
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Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb
L-Serine + 2-Aminoacrylic acid + 2-Iminopropanoate + Water ↔ Pyruvic acid + Ammonia
ReactionCard
SMPDB Reactions:
L-Serine+Thumb → Thumb+Thumb+Thumb
L-Serine + L-Serine → Water + Hydrogen ion + 2-Aminoacrylic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb
L-Serine ↔ Pyruvic acid + Ammonia
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Thumb → Thumb+Thumb+Thumb
L-Serine → Hydrogen ion + Pyruvic acid + Ammonia
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
L-Serine → Ammonium + Pyruvic acid
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0005192-Aminoacrylic acidMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000077L-SerineMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
4 iron, 4 sulfur cluster binding
ammonia-lyase activity
binding
carbon-nitrogen lyase activity
catalytic activity
iron-sulfur cluster binding
L-serine ammonia-lyase activity
lyase activity
metal cluster binding
Process
alcohol metabolic process
gluconeogenesis
glucose metabolic process
hexose metabolic process
metabolic process
monosaccharide metabolic process
small molecule metabolic process
Gene Properties
Locus tag: PA2443
Strand: -
Entrez Gene ID: 882930
Accession: NP_251133.1
GI: 15597639
Sequence start: 2740977
Sequence End: 2742353
Sequence Length: 1376
Gene Sequence: 
>PA2443
ATGTCCCTGAGTGTCTTCGATCTGTTCAAGATCGGCATCGGGCCGTCCAGCTCCCACACCGTGGGGCCGATGCGTGCCGCCGCGCGCTTTGCCGAGGGGCTGAGGCGCGAGGGGTTGCTGGAGGCCACTGCCAGCATCAAGGTCGAGCTGTACGGCTCGCTCGGCGCCACCGGCAAGGGCCACGGCAGCGACAAGGCGGTACTGCTCGGCCTGGAGGGCGAGCAGCCGGACACGGTGGATACCGCCGCGATTCCCGCTCGGCTCGATGCCATCCGTTCCAGCGGCGAGCTGCGCCTGCTCGGCGAGCGGCCGATCCGCTTCGTCGAGAAGGAACACCTTGCGCTGATCCGCAAGCCGCTGGCCTACCATCCCAACGGCATGATCTTCCGTGCCTTCGACGCCGCCGGCCTGCAGGTCCGCAGCCGCGAGTACTACTCGGTGGGCGGCGGTTTCGTGGTCGACGACGAGGCCGCCGGCCTCGACCGCATCGTCGAGGACCGCACGCCGCTGGCGTTCCCCTTCAAGACCGCGCGGCAACTGCTCGACCATTGCGCCCGCGAAGGCCTGTCGATCAGCCAGTTGATGGCCGAGAACGAGAAGGCCTGGCGCCCCGCCGAGGAAACCCGCACCGGCCTGCTGCGTATCTGGCAGGTGATGCAGGACTGCGTCGAGGCCGGCTGCCGCAACGAGGGCATCATGCCCGGCGGACTGAAGGTCAGGCGCCGTGCGGCGGCGCTCCACCGCCAGTTGTGCCAGCGGCCGGAGGCCGGTCTGCGCGACGCCCTCAGCGTGCTCGACTGGGTCAACCTCTACGCCCTGGCGGTGAACGAGGAGAACGCCAGCGGCGGCCGCGTGGTGACCGCGCCGACCAACGGCGCGGCGGGGATCATTCCGGCGGTGCTGCATTACTACGCGCGCTTCATCCCCGGGGCCGACGACGACGGCGTGGTGCGCTTCCTGCTCACCGCGGCGGCGATCGGCATCCTCTACAAGGAAAACGCCTCGATCTCCGGCGCCGAGGTCGGTTGCCAGGGCGAGGTCGGCGTGGCCTGCTCGATGGCTGCCGGGGCGCTCTGCGAAGTGCTCGGCGGTAGCGTGCAGCAGGTCGAGAACGCCGCCGAAATCGGCATGGAGCACAACCTCGGGCTGACCTGCGACCCGGTCGGCGGGCTGGTCCAGGTGCCCTGCATCGAACGCAACGCGATGGCTTCGGTGAAGGCGATCAACGCCGCGCGCATGGCCCTGCGCGGCGACGGCCAGCACTTCATTTCCCTCGACAAGGTCATCCGCACCATGCGCCAGACCGGCGCCGACATGAAAAGCAAATACAAGGAAACCGCGCGCGGCGGCCTCGCCGTGAACATCATCGAATGCTGA
Protein Properties
Protein Residues: 458
Protein Molecular Weight: 48.9 kDa
Protein Theoretical pI: 6.78
Hydropathicity (GRAVY score): -0.01
Charge at pH 7 (predicted): -1.12
Protein Sequence: 
>PA2443
MSLSVFDLFKIGIGPSSSHTVGPMRAAARFAEGLRREGLLEATASIKVELYGSLGATGKGHGSDKAVLLGLEGEQPDTVDTAAIPARLDAIRSSGELRLLGERPIRFVEKEHLALIRKPLAYHPNGMIFRAFDAAGLQVRSREYYSVGGGFVVDDEAAGLDRIVEDRTPLAFPFKTARQLLDHCAREGLSISQLMAENEKAWRPAEETRTGLLRIWQVMQDCVEAGCRNEGIMPGGLKVRRRAAALHRQLCQRPEAGLRDALSVLDWVNLYALAVNEENASGGRVVTAPTNGAAGIIPAVLHYYARFIPGADDDGVVRFLLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGALCEVLGGSVQQVENAAEIGMEHNLGLTCDPVGGLVQVPCIERNAMASVKAINAARMALRGDGQHFISLDKVIRTMRQTGADMKSKYKETARGGLAVNIIEC
References
External Links:
Resource Link
Genome ID: PA2443
Entrez Gene ID: 882930
NCBI Protein ID: 15597639
General Reference: PaperBLAST - Find papers about PA2443 and its homologs