Penicillin-binding protein 1C (PA2272)

Identification
Name: Penicillin-binding protein 1C
Synonyms:
  • PBP-1c
  • PBP1c
  • Penicillin-insensitive transglycosylase
  • Peptidoglycan TGase
  • Transpeptidase-like module
Gene Name: pbpC
Enzyme Class: Not Available
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional
Cellular Location: Cell inner membrane; Single-pass type II membrane protein
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions:
2 Thumb → Thumb+Thumb+ a peptidoglycan dimer (meso-diaminopimelate containing)
2 lipid II(A) → Undecaprenyl diphosphate + Hydrogen ion + a peptidoglycan dimer (meso-diaminopimelate containing)
ReactionCard
2 Thumb → a peptidoglycan dimer (meso-diaminopimelate containing)+Thumb+Thumb
2 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine → a peptidoglycan dimer (meso-diaminopimelate containing) + Undecaprenyl diphosphate + Hydrogen ion
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb → Thumb+a peptidoglycan dimer (meso-diaminopimelate containing)+Thumb
N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine → Hydrogen ion + a peptidoglycan dimer (meso-diaminopimelate containing) + Undecaprenyl diphosphate
ReactionCard
Complex Reactions:
Thumb+two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain) → Thumb+Thumb+three linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)
Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain) → Hydrogen ion + Undecaprenyl diphosphate + three linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)
ReactionCard
2 Thumb → 2 Thumb+2 Thumb+two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)
2 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine → 2 Hydrogen ion + 2 Undecaprenyl diphosphate + two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001633Hydrogen ionMetaboCard
PAMDB003413lipid II(A)MetaboCard
PAMDB001129N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamineMetaboCard
PAMDB000394Undecaprenyl diphosphateMetaboCard
PAMDB001056Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineMetaboCard
PAMDB001058Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineMetaboCard
GO Classification:
Component
cell part
cell wall
external encapsulating structure
peptidoglycan-based cell wall
Function
binding
catalytic activity
drug binding
penicillin binding
Process
aminoglycan metabolic process
carbohydrate metabolic process
cell wall biogenesis
cell wall organization or biogenesis
cellular cell wall organization or biogenesis
cellular component organization or biogenesis
glycosaminoglycan metabolic process
metabolic process
peptidoglycan biosynthetic process
peptidoglycan metabolic process
peptidoglycan-based cell wall biogenesis
polysaccharide metabolic process
primary metabolic process
Gene Properties
Locus tag: PA2272
Strand: +
Entrez Gene ID: 882173
Accession: NP_250962.1
GI: 15597468
Sequence start: 2501720
Sequence End: 2503417
Sequence Length: 1697
Gene Sequence: 
>PA2272
ATGAGCAGTCAACGCCGAAACTACCGCTTCATCCTTGTCGTCACCCTGTTCGTCCTCGCCTCCCTGGCCGTCTCCGGACGGTTGGTCTATCTCCAGGTCCACGACCACGAATTCCTCGCCGACCAGGGCGACCTCCGCTCGATCCGCGACCTGCCGATCCCGGTCACCCGCGGCATGATCACCGACCGCAACGGCGAGCCGCTGGCGGTATCCACCGAAGTCGCGTCGATCTGGTGCAACCCCAGGGAAATGGCCGCCCACCTCGACGAGGTGCCGCGCCTGGCCGGCGCCCTGCACCGCCCCGCGGCGGCGCTGCTGGCCCAGCTCCAGGCCAACCCGAACAAGCGCTTCCTCTACCTCGAGCGCGGCCTGTCGCCGATCGAGGCCAGCGAGGTGATGGCCCTGGGCATAACGGGGGTACACCAGATCAAGGAATACAAGCGTTTCTACCCCAGTTCCGAGCTGACCGCGCAGTTGATCGGCCTGGTCAACATCGACGGCCGCGGCCAGGAAGGCACCGAACTGGGCTTCAACGACTGGCTGAGCGGCAAGGACGGGGTACGCGAGGTGGCGATCAACCCGCGCGGCTCGCTGGTCAACAGCATCAAGGTGCTGAAGACGCCCAAGGCCAGCCAGGACGTGGCCCTGAGCATCGACCTGCGACTACAGTTCATCGCCTACAAGGCGCTGGAAAAGGCCGTGCTCAAGTTCGGCGCGCACTCCGGCTCGGCGGTCCTGGTGAACCCGAAGAGCGGGCAGATCCTGGCGATGGCCAACTTCCCCTCCTACAACCCGAACAACCGCGCCAGCTTCGCCCCGGCCTTCATGCGCAACCGCACCCTCACCGATACCTTCGAGCCGGGCTCGGTGATCAAGCCGTTCAGCATGTCGGCGGCGCTGGCCTCCGGCAAGTTCGACGAGAACAGTCAAGTCAGCGTGGCACCGGGCTGGATGACCATCGACGGGCACACCATCCACGACGTCGCCCGGCGCGACGTACTGACCATGACCGGGGTGCTGATCAACTCCTCGAACATCGGCATGAGCAAGGTCGCCCTGCAGATCGGACCCAAGCCGATCCTCGAACAGCTCGGCCGGGTCGGTTTCGGCGCGCCGCTGTCGCTGGGCTTCCCCGGCGAGAACCCGGGCTACCTGCCGTTCCACGAGAAATGGTCGAACATCGCCACCGCCAGCATGTCGTTCGGCTACAGCCTGGCGGTGAACACCGCCGAGCTGGCCCAGGCCTACTCGGTGTTCGCCAACGACGGCAAGCTGGTGCCGCTCAGCCTGCTCCGCGACAACCCGCAGAACCAGGTGCGACAGGCGATGGACCCGCAGATCGCACGGCGCATCCGGGCGATGCTGCAAACCGTGGTGGAAGACCCGAAGGGCGTGGTCCGCGCCCGCGTGCCGGGCTACCACGTGGCGGGCAAGAGCGGCACCGCGCGCAAGGCCTCGGGCCGGGGCTACGCGGACAAGTCCTACCGTTCGCTGTTCGTCGGCATGGCGCCGGCGTCCGACCCGCAACTGGTGCTGGCGGTGATGATCGATTCGCCGACCAGGATCGGCTACTTCGGCGGCCTGGTCTCGGCGCCCACCTTCAGCGACATCATGGCCGGATCGCTACGCGCCCTGGCGATCCCGCCGGACAACCTGCAGGACAGCCCGGCCGTCGCCGACCGCCAGCACCACGGCTGA
Protein Properties
Protein Residues: 565
Protein Molecular Weight: 61.1 kDa
Protein Theoretical pI: 9.92
Hydropathicity (GRAVY score): -0.058
Charge at pH 7 (predicted): 12.86
Protein Sequence: 
>PA2272
MSSQRRNYRFILVVTLFVLASLAVSGRLVYLQVHDHEFLADQGDLRSIRDLPIPVTRGMITDRNGEPLAVSTEVASIWCNPREMAAHLDEVPRLAGALHRPAAALLAQLQANPNKRFLYLERGLSPIEASEVMALGITGVHQIKEYKRFYPSSELTAQLIGLVNIDGRGQEGTELGFNDWLSGKDGVREVAINPRGSLVNSIKVLKTPKASQDVALSIDLRLQFIAYKALEKAVLKFGAHSGSAVLVNPKSGQILAMANFPSYNPNNRASFAPAFMRNRTLTDTFEPGSVIKPFSMSAALASGKFDENSQVSVAPGWMTIDGHTIHDVARRDVLTMTGVLINSSNIGMSKVALQIGPKPILEQLGRVGFGAPLSLGFPGENPGYLPFHEKWSNIATASMSFGYSLAVNTAELAQAYSVFANDGKLVPLSLLRDNPQNQVRQAMDPQIARRIRAMLQTVVEDPKGVVRARVPGYHVAGKSGTARKASGRGYADKSYRSLFVGMAPASDPQLVLAVMIDSPTRIGYFGGLVSAPTFSDIMAGSLRALAIPPDNLQDSPAVADRQHHG
References
External Links:
Resource Link
Genome ID: PA2272
Entrez Gene ID: 882173
NCBI Protein ID: 15597468
General Reference: PaperBLAST - Find papers about PA2272 and its homologs