probable 3-hydroxyacyl-CoA dehydrogenase (PA1737)

Identification
Name: probable 3-hydroxyacyl-CoA dehydrogenase
Synonyms: fadB
Gene Name: Not Available
Enzyme Class: Not Available
Biological Properties
General Function: metabolic process, oxidation-reduction process, fatty acid metabolic process
Specific Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding, oxidoreductase activity, catalytic activity, 3-hydroxyacyl-CoA dehydrogenase activity
Cellular Location: Cytoplasmic
KEGG Pathways:
  • androstenedione degradation PWY-6944
  • crotonate fermentation (to acetate and cyclohexane carboxylate) PWY-7401
  • fatty acid β-oxidation I FAO-PWY
  • phenylacetate degradation I (aerobic) PWY0-321
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    PAMDB120265+PAMDB110542 → PAMDB120027+PAMDB110540+PAMDB001633
    (S)-3-hydroxyoctanoyl-CoA + NAD+ → 3-oxooctanoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120036+Acceptor → PAMDB120020+Donor-H2
    2-carboxymethyl-3-hydroxyphenylpropanoyl-CoA + Acceptor → benzoylsuccinyl-CoA + Donor-H2
    ReactionCard
    Thumb
    acetoacetyl-CoA + NADH = (R)-3-hydroxybutanoyl-CoA + NAD+
    ReactionCard
    PAMDB120596+PAMDB110542 → PAMDB120590+PAMDB110540+PAMDB001633
    3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA + NAD+ → 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120104+PAMDB110542 → PAMDB120235+PAMDB110540+PAMDB001633
    3-hydroxy-5-trans-dodecenoyl-CoA + NAD+ → 5-trans-3-oxo-dodecenoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120166+PAMDB110542 → PAMDB120423+PAMDB110540+PAMDB001633
    3-hydroxy- 5-cis, 7-trans-tetradecadienoyl-CoA + NAD+ → 5-cis, 7-trans-3-oxo-tetradecadienoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120222+PAMDB110542 → PAMDB120405+PAMDB110540+PAMDB001633
    3-hydroxy, 4-trans-undecenoyl-CoA + NAD+ → 4-trans-3-oxo-undecenoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    L-3-HYDROXYACYL-COA+PAMDB110542 → 3-KETOACYL-COA+PAMDB110540+PAMDB001633
    L-3-HYDROXYACYL-COA + NAD+ → 3-KETOACYL-COA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120180+PAMDB110542 → PAMDB120306+PAMDB110540+PAMDB001633
    OPC8-3-hydroxyacyl-CoA + NAD+ → OPC8-3-ketoacyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120296+PAMDB110542 → PAMDB120389+PAMDB110540+PAMDB001633
    3-hydroxy, 6-trans-tridecenoyl-CoA + NAD+ → 6-trans-3-oxo-tridecenoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120354+PAMDB110542 → PAMDB120340+PAMDB110540+PAMDB001633
    OPC6-3-hydroxyacyl-CoA + NAD+ → OPC6-3-ketoacyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120508+PAMDB110542 → PAMDB120367+PAMDB110540+PAMDB001633
    OPC4-3-hydroxyacyl-CoA + NAD+ → OPC4-3-ketoacyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120355+PAMDB110542 → PAMDB120364+PAMDB110540+PAMDB001633
    3-hydroxy, 6-cis-tridecenoyl-CoA + NAD+ → 6-cis, 3-oxo-tridecenoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120075+PAMDB110542 → PAMDB120400+PAMDB110540+PAMDB001633
    3-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA + NAD+ → 4-hydroxybenzoyl-acetyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120391+PAMDB110542 → PAMDB120369+PAMDB110540+PAMDB001633
    (S)-3-hydroxyhexadecanoyl-CoA + NAD+ → 3-oxo-palmitoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120417+PAMDB110542 → PAMDB120345+PAMDB110540+PAMDB001633
    3-hydroxy-5-cis-tetradecenoyl-CoA + NAD+ → 3-keto-5-cis-tetradecenoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    Long-Chain-3S-Hydroxyacyl-CoAs+PAMDB110542 → Long-Chain-oxoacyl-CoAs+PAMDB110540+PAMDB001633
    Long-Chain-3S-Hydroxyacyl-CoAs + NAD+ → Long-Chain-oxoacyl-CoAs + NADH + Hydrogen ion
    ReactionCard
    D-3-HYDROXYACYL-COA+PAMDB110542 → 3-KETOACYL-COA+PAMDB110540+PAMDB001633
    D-3-HYDROXYACYL-COA + NAD+ → 3-KETOACYL-COA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120480+PAMDB110542 → PAMDB120469+PAMDB110540+PAMDB001633
    (S)-3-hydroxyhexanoyl-CoA + NAD+ → 3-oxohexanoyl-CoA + NADH + Hydrogen ion
    ReactionCard
    PAMDB120234+PAMDB110542 → PAMDB001633+PAMDB110398+PAMDB110540
    3-hydroxyadipyl-CoA + NAD+ → Hydrogen ion + 3-oxoadipyl-CoA + NADH
    ReactionCard
    PAMDB120564+PAMDB110542 → PAMDB120541+PAMDB110540+PAMDB001633
    24-hydroxy-3-oxocholest-4-en-26-oyl-CoA + NAD+ → 3,24-dioxocholest-4-en-26-oyl-CoA + NADH + Hydrogen ion
    ReactionCard
    Long-Chain-3S-Hydroxyacyl-CoAs → Long-Chain-Trans-23-Dehydroacyl-CoA+PAMDB000142
    Long-Chain-3S-Hydroxyacyl-CoAs → Long-Chain-Trans-23-Dehydroacyl-CoA + Water
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites: Not Available
    GO Classification:
    Function
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    coenzyme binding
    oxidoreductase activity
    catalytic activity
    3-hydroxyacyl-CoA dehydrogenase activity
    Process
    metabolic process
    oxidation-reduction process
    fatty acid metabolic process
    Gene Properties
    Locus tag: PA1737
    Strand: +
    Entrez Gene ID: 878600
    Accession: NP_250428.1
    GI: 15596934
    Sequence start: 1880199
    Sequence End: 1882343
    Sequence Length: 2144
    Gene Sequence: 
    >PA1737
ATGACTGACGCTATCCGTTACGAAAAAGGCCAGGACAACGTCGTCGTCCTGACCATGGACATGCCCGGGCAGAGCGCCAACACCATGAACGGTGTCTACCGCGAGGCGATGGCGAAGACCATCGCACGGCTGGAGGCGGAGAAAGAGGGGATCGCCGGCGTGGTGCTGACCTCGGCGAAGAAGACCTTCTTCGCCGGCGGCGATCTCAACGAGCTGATCAAGGTCACCAAGGCCGACGCCCCGGCCTTCTACCAGGGCATCCTCGAACTCAAGGGCCAACTGCGGCGCCTGGAGACCCTCGGCAAGCCGGTGGTCGCCGCGATCAACGGCGCTGCGCTGGGCGGCGGCTGGGAGATCTGCCTGGCCTGCCACCACCGCATCGCCCTGGACAATCCCGGCGTGCAGCTCGGCCTGCCGGAGGTGACTCTCGGCCTGTTGCCGGGCGGCGGCGGGATCGTGCGCATGGTGCGCCTGCTTGGTCTGGAGAAAGCCCTGCCGTACCTCGCCGAAGGCAAGAAGGTGCGTCCGGCGGAAGCGCTCAAGGCCGGGCTGATCCACGAACTGGCCGACAGCCCCGAGGAAATGCTGGAGAAGGCCCGCGCCTGGATCCTCGCCAACCCGGCGGCGAAGCAGCCCTGGGACAGCGCCGGCTACAAGATTCCCGGCGGTACGCCTGCCAGTCCCAACGTGGCGCAGATGCTGGCCATCGCACCGTCGGTGCTGCGCGACAAGACCAAGGGTTGCTTCCCGGCGCCCGAGAAGATCATGTGCGCGGCGGTGGAGGGCGCCCAGGTCGATTTCGACACCGCGCAACTGATCGAGGCGCGCTATTTCACCGAGCTGACCACCGGCCAGGTGGCGAAGAACATGATCGGCACCTTCTGGTTCCAGCTCAACGAGATCAACGCCGGCAAGTCGCGGCCGCAGGGGTATCCGGTGCGGGCGACGAAAAAGGTCGGCGTGCTCGGCGCCGGGATGATGGGCGCGGGCATCGCCTACGTATCGGCGGCGGCCGGCATCGAGGTGGTGCTCAAGGACGTCTCGCTGGAAGCGGCGGAGAAGGGCAAGGCTTATTCGGCCAGGCTGCTGGACAAGAAAGTTGCGCGCGGGCACCTGTCCGCCGAGAAGCGCGACGCCTTCCTCGCGCGGATCGTGCCGAGCGTCAGCGAAGCCGACTTCGAAGGCTGCGACCTGATCATCGAGGCGGTCTTCGAGGACCGCGCGCTGAAAGGCAAGGTCACCGCCGAGGCCGAGAAACATGCCCTGGCCGATGCGGTGGTGGCGTCCAATACCTCGACCCTGCCGATCACCGGTCTGGCCCAGGCGGTGGCGCGGCCGGAGAAGTTCATCGGCCTGCACTTCTTCAGCCCGGTGGACAAGATGCCGCTGGTGGAGATCATCCGCGGCGAAAAGACCAGCGACGAAACCCTGGCACGCGGTTTCGACTACGTGCTGCAGATCAAGAAAACGCCGATCGTGGTCAACGACAGCCGCGGCTTCTTCACCTCGCGGGTATTCGGCACCTTCACCAACGAAGGCATCGCCATGCTCGGCGAAGGCGTGAGCGCCGCGATGATCGACAACCAGGCGCGCCAGGCCGGTATGCCGGTGGGGCCGCTGGCGATTTCCGACGAAGTCTCGCTGAGCCTGATGACCCACATCCGCAACCAGACCGCCCGCGACCTCGAGGCCGAGGGCAAGGCTCTGCCGACGCACCCCGCGTTCGCCGTGATCGACCTGATGGTCAATGAGTACAAGCGCCCGGGCAAGGCGGCCGGCGCCGGCTTCTACGACTACCCGGCGAACGGCAGGAAACATCTCTGGGCGGAACTCAAGAGCCGCTTCGAGAAGCCCGATGCGCAAATATCCGCCGAGGACGTACGCGACCGCCTGCTGTTCATCCAGGCCATCGAGACCGTGCGTTGCGTGGAGGAGGGGGTATTGCACTCCACCGCCGACGCGAACATCGGCTCGATCTTCGGTATCGGTTTCGCCGCCTGGAGCGGGGGCGCCTTGCAGTTCATCAACCAGTACGGCCTGAAGGACTTCATCGCCCGCGCCCAATACCTGGTCGAACAGTACGGCGAGCGCTTCGAGCCGCCGGCGCTGTTGCTGGAGAAGGCGGCGAAGGGCGAGCTGTTCTGA
    Protein Properties
    Protein Residues: 714
    Protein Molecular Weight: 76.7 kDa
    Protein Theoretical pI: 6.69
    Hydropathicity (GRAVY score): -0.011
    Charge at pH 7 (predicted): -1.73
    Protein Sequence: 
    >PA1737
MTDAIRYEKGQDNVVVLTMDMPGQSANTMNGVYREAMAKTIARLEAEKEGIAGVVLTSAKKTFFAGGDLNELIKVTKADAPAFYQGILELKGQLRRLETLGKPVVAAINGAALGGGWEICLACHHRIALDNPGVQLGLPEVTLGLLPGGGGIVRMVRLLGLEKALPYLAEGKKVRPAEALKAGLIHELADSPEEMLEKARAWILANPAAKQPWDSAGYKIPGGTPASPNVAQMLAIAPSVLRDKTKGCFPAPEKIMCAAVEGAQVDFDTAQLIEARYFTELTTGQVAKNMIGTFWFQLNEINAGKSRPQGYPVRATKKVGVLGAGMMGAGIAYVSAAAGIEVVLKDVSLEAAEKGKAYSARLLDKKVARGHLSAEKRDAFLARIVPSVSEADFEGCDLIIEAVFEDRALKGKVTAEAEKHALADAVVASNTSTLPITGLAQAVARPEKFIGLHFFSPVDKMPLVEIIRGEKTSDETLARGFDYVLQIKKTPIVVNDSRGFFTSRVFGTFTNEGIAMLGEGVSAAMIDNQARQAGMPVGPLAISDEVSLSLMTHIRNQTARDLEAEGKALPTHPAFAVIDLMVNEYKRPGKAAGAGFYDYPANGRKHLWAELKSRFEKPDAQISAEDVRDRLLFIQAIETVRCVEEGVLHSTADANIGSIFGIGFAAWSGGALQFINQYGLKDFIARAQYLVEQYGERFEPPALLLEKAAKGELF
    References
    External Links:
    Resource Link
    Genome ID: PA1737
    Entrez Gene ID: 878600
    NCBI Protein ID: 15596934
    General Reference: PaperBLAST - Find papers about PA1737 and its homologs