Pyridoxine/pyridoxamine 5'-phosphate oxidase (PA1049)

Identification
Name: Pyridoxine/pyridoxamine 5'-phosphate oxidase
Synonyms:
  • PNP/PMP oxidase
  • PNPOx
  • Pyridoxal 5'-phosphate synthase
Gene Name: pdxH
Enzyme Class:
Biological Properties
General Function: Coenzyme transport and metabolism
Specific Function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
Oxygen + Pyridoxine 5'-phosphate → Hydrogen peroxide + Pyridoxal 5'-phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Pyridoxamine 5'-phosphate + Water + Oxygen ↔ Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Pyridoxine 5'-phosphate + Oxygen ↔ Hydrogen peroxide + Pyridoxal 5'-phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Pyridoxamine + Water + Oxygen ↔ Pyridoxal + Ammonia + Hydrogen peroxide
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Pyridoxine + Oxygen ↔ Pyridoxal + Hydrogen peroxide
ReactionCard
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Pyridoxamine 5'-phosphate + Water + Oxygen + Pyridoxine 5'-phosphate ↔ Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb
Pyridoxine 5'-phosphate + Oxygen → Pyridoxal 5'-phosphate + Hydrogen peroxide
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Pyridoxamine 5'-phosphate + Oxygen + Water → Pyridoxal 5'-phosphate + Hydrogen peroxide + Ammonium
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Oxygen + Pyridoxine 5'-phosphate → Hydrogen peroxide + Pyridoxal 5'-phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Pyridoxamine 5'-phosphate + Water + Oxygen ↔ Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide
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Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Water + Oxygen + Pyridoxamine 5'-phosphate → Hydrogen peroxide + Ammonium + Pyridoxal 5'-phosphate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Pyridoxamine 5'-phosphate + Water + Oxygen → Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide
ReactionCard
Thumb+Thumb → Thumb+Thumb
Pyridoxine 5'-phosphate + Oxygen → Pyridoxal 5'-phosphate + Hydrogen peroxide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB001640Hydrogen peroxideMetaboCard
PAMDB000624OxygenMetaboCard
PAMDB000414PyridoxalMetaboCard
PAMDB000400Pyridoxal 5'-phosphateMetaboCard
PAMDB000384PyridoxamineMetaboCard
PAMDB000420Pyridoxamine 5'-phosphateMetaboCard
PAMDB000099PyridoxineMetaboCard
PAMDB000338Pyridoxine 5'-phosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
FMN binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-NH2 group of donors
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
pyridoxamine-phosphate oxidase activity
Process
metabolic process
oxidation reduction
pyridoxine biosynthetic process
pyridoxine metabolic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Properties
Locus tag: PA1049
Strand: +
Entrez Gene ID: 881467
Accession: NP_249740.1
GI: 15596246
Sequence start: 1136388
Sequence End: 1137035
Sequence Length: 647
Gene Sequence: 
>PA1049
ATGACCCAGTCCCTGGCCGATATGCGCCGCGAGTACACCCGCGATGGCCTCAGCGAGGCCAACGCCCCTAGCGATCCCTTCAGCCTGTTCCGCCAGTGGTTCGACGACGCGGTGAAGACCGAGCGCCTGCCGGTCGAACCCAACGCCATGACCCTGGCCACCGTCGACGCCGACGGCTATCCGCATTGCCGTATCCTCCTGCTCAAGGGCCTCGACGAGCGCGGCTTCACCTTCTTCACCAACTACGAAAGCGCCAAGGGCCGGCAACTGGCGGCCAATCCGCGGGCGGCCATGACCTTCTTCTGGCCGGCGCTGGAGCGCCAGGTGCGCATCGAAGGCAGCGTCGAGAAGGTCACTCCCGAGGAATCCGACGCCTACTACCAGGTGCGTCCGCTGGGCAGTCGCCTGGGCGCCTGGGCCTCGCCGCAGAGCCGGGTCATCGCCGATCGCGCCGAGCTGGAACGGCTGCTCGCGGACACCGAGCGGCGTTTCGCCGACCAGCCGCCGAGCTGTCCCGAGCACTGGGGCGGCTACCGTCTCCTGCCGCAGCGCATCGAGTTCTGGCAGGGGCGGCCGAGCCGCCTGCACGACCGTCTCGACTATCGACGCCAGGACGGCGGCTGGCTGCGCGAACGCCTGGCGCCCTGA
Protein Properties
Protein Residues: 215
Protein Molecular Weight: 24.9 kDa
Protein Theoretical pI: 6.8
Hydropathicity (GRAVY score): -0.726
Charge at pH 7 (predicted): -0.34
Protein Sequence: 
>PA1049
MTQSLADMRREYTRDGLSEANAPSDPFSLFRQWFDDAVKTERLPVEPNAMTLATVDADGYPHCRILLLKGLDERGFTFFTNYESAKGRQLAANPRAAMTFFWPALERQVRIEGSVEKVTPEESDAYYQVRPLGSRLGAWASPQSRVIADRAELERLLADTERRFADQPPSCPEHWGGYRLLPQRIEFWQGRPSRLHDRLDYRRQDGGWLRERLAP
References
External Links:
Resource Link
Genome ID: PA1049
Entrez Gene ID: 881467
NCBI Protein ID: 15596246
General Reference: PaperBLAST - Find papers about PA1049 and its homologs