Dihydrodipicolinate synthase (PA1010)

Identification
Name: Dihydrodipicolinate synthase
Synonyms:
  • DHDPS
Gene Name: dapA
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb+2 Thumb
L-Aspartate-semialdehyde + Pyruvic acid → 2,3-Dihydrodipicolinic acid + Hydrogen ion + 2 Water
ReactionCard
Thumb+Thumb ↔ Thumb+2 Thumb
L-Aspartate-semialdehyde + Pyruvic acid ↔ 2,3-Dihydrodipicolinic acid + 2 Water
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Pyruvic acid + L-Aspartate-semialdehyde ↔ (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate + Water
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate+Thumb
L-Aspartate-semialdehyde + Pyruvic acid → Hydrogen ion + Water + (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
ReactionCard
Thumb+Thumb ↔ 2 Thumb+Thumb
L-Aspartate-semialdehyde + Pyruvic acid ↔ 2 Water + 2,3-Dihydrodipicolinic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+2 Thumb
L-Aspartate-semialdehyde + Pyruvic acid → 2,3-Dihydrodipicolinic acid + Hydrogen ion + 2 Water
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB004261(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinateMetaboCard
PAMDB0005882,3-Dihydrodipicolinic acidMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000833L-Aspartate-semialdehydeMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
carbon-oxygen lyase activity
catalytic activity
dihydrodipicolinate synthase activity
hydro-lyase activity
lyase activity
Process
carboxylic acid biosynthetic process
cellular metabolic process
diaminopimelate biosynthetic process
metabolic process
organic acid biosynthetic process
organic acid metabolic process
Gene Properties
Locus tag: PA1010
Strand: +
Entrez Gene ID: 879525
Accession: NP_249701.1
GI: 15596207
Sequence start: 1093251
Sequence End: 1094129
Sequence Length: 878
Gene Sequence: 
>PA1010
ATGATTGCGGGCAGTATGGTGGCACTGGTCACCCCCTTCGATGCTCAGGGTCGACTGGACTGGGACAGCCTCGCCAAGCTGGTGGACTTCCACTTGCAGGAAGGCACCAACGCCATCGTCGCCGTCGGCACCACCGGTGAATCGGCCACGCTGGACGTGGAAGAGCACATCCAGGTGATCCGTCGCGTGGTCGACCAGGTTAAGGGCCGCATCCCGGTGATCGCCGGCACCGGCGCCAACTCCACCCGCGAGGCGGTGGCGCTGACCGAGGCCGCGAAAAGCGGCGGCGCCGACGCCTGCCTGCTGGTGACGCCGTACTACAACAAGCCGACCCAGGAAGGCATGTACCAGCACTTCCGCCATATCGCCGAAGCCGTTGCGATCCCGCAGATCCTCTACAACGTACCGGGCCGCACCTCCTGCGACATGCTTCCGGAGACCGTCGAGCGCCTGTCCAAGGTGCCGAACATCATCGGCATCAAGGAGGCCACCGGCGACCTGCAACGCGCCAAGGAAGTCATCGAGCGCGTCGGCAAGGACTTCCTCGTCTATTCCGGCGACGACGCCACGGCCGTCGAGCTGATGCTGCTGGGTGGCAAGGGCAACATCTCGGTGACCGCCAACGTCGCGCCGCGCGCCATGAGCGACCTGTGCGCCGCCGCCATGCGCGGCGACGCCGCAGCCGCGCGCGCCATCAACGATCGCCTGATGCCGCTGCACAAGGCGCTGTTCATCGAATCCAACCCCATTCCGGTGAAGTGGGCCCTGCATGAGATGGGTCTGATCCCCGAGGGCATCCGCCTGCCCCTGACCTGGCTCAGCCCGCGTTGCCACGAGCCGCTGCGTCAGGCCATGCGCCAGACCGGCGTATTGGCTTGA
Protein Properties
Protein Residues: 292
Protein Molecular Weight: 31.4 kDa
Protein Theoretical pI: 6.4
Hydropathicity (GRAVY score): 0.043
Charge at pH 7 (predicted): -2.44
Protein Sequence: 
>PA1010
MIAGSMVALVTPFDAQGRLDWDSLAKLVDFHLQEGTNAIVAVGTTGESATLDVEEHIQVIRRVVDQVKGRIPVIAGTGANSTREAVALTEAAKSGGADACLLVTPYYNKPTQEGMYQHFRHIAEAVAIPQILYNVPGRTSCDMLPETVERLSKVPNIIGIKEATGDLQRAKEVIERVGKDFLVYSGDDATAVELMLLGGKGNISVTANVAPRAMSDLCAAAMRGDAAAARAINDRLMPLHKALFIESNPIPVKWALHEMGLIPEGIRLPLTWLSPRCHEPLRQAMRQTGVLA
References
External Links:
Resource Link
Genome ID: PA1010
Entrez Gene ID: 879525
NCBI Protein ID: 15596207
General Reference: PaperBLAST - Find papers about PA1010 and its homologs