Quinolinate synthase A (PA1004)

Identification
Name: Quinolinate synthase A
Synonyms: Not Available
Gene Name: nadA
Enzyme Class:
Biological Properties
General Function: Involved in quinolinate synthetase A activity
Specific Function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Cellular Location: Cytoplasm
KEGG Pathways:
  • Nicotinate and nicotinamide metabolism pae00760
KEGG Reactions:
Thumb+Thumb ↔ 2 Thumb+Thumb+Thumb
Dihydroxyacetone phosphate + Iminoaspartic acid ↔ 2 Water + Phosphate + Quinolinic acid
ReactionCard
Thumb+2 Thumb+Thumb ↔ Thumb+Thumb
Quinolinic acid + 2 Water + Phosphate ↔ Iminoaspartic acid + Dihydroxyacetone phosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+2 Thumb+Thumb
Iminoaspartic acid + Dihydroxyacetone phosphate → Phosphate + 2 Water + Quinolinic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ 2 Thumb+Thumb+Thumb
Dihydroxyacetone phosphate + Iminoaspartic acid ↔ 2 Water + Phosphate + Quinolinic acid
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+2 Thumb+Thumb
Dihydroxyacetone phosphate + Iminoaspartic acid → Quinolinic acid + 2 Water + Inorganic phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000395Dihydroxyacetone phosphateMetaboCard
PAMDB000267Iminoaspartic acidMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000096Quinolinic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
quinolinate synthetase A activity
Process
cellular metabolic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
Gene Properties
Locus tag: PA1004
Strand: +
Entrez Gene ID: 883095
Accession: NP_249695.1
GI: 15596201
Sequence start: 1087843
Sequence End: 1088901
Sequence Length: 1058
Gene Sequence: 
>PA1004
ATGACGCACATTTCCGAACGACTCCTGGTACAGGCCCACCTGGCCGCCAAGCAACCCCGTGTGTTGAGCGAGCAGGAGAGCGCCGAGCATCGCGCGGCGATCGCGGCCGAACTGAAGGCGCAAAATGCTGTACTGGTGGCGCATTACTACTGCGACCCGGTGATCCAGGCGTTGGCCGAGGAGACCGGCGGTTGCGTATCCGATTCGCTGGAGATGGCCCGTTTCGGCAACCAGCATCCGGCGCAGACGGTGGTCGTGGCCGGGGTGCGCTTCATGGGCGAGACGGCGAAGATCCTCAACCCTGAGAAGCGTGTGCTGATGCCGACCCTCGAAGCGACCTGCTCGCTCGACCTGGGATGCCCGGTGGATGAATTCTCGGCTTTCTGCGACCAGCACCCGGAACGGACCGTGGTGGTCTATGCGAACACCTCCGCGGCGGTGAAGGCACGCGCCGACTGGGTCGTGACCTCCAGTTGCGCGGTGGAGATCGTCGAACACCTGATGGACAACGGCGAGCCCATCCTCTGGGCGCCGGACCAGCACCTGGGACGCTACATCCAGCGCGAGACGGGGGCCGACATGCTGCTCTGGGATGGCGCCTGTATCGTCCACGAGGAGTTCAAGGCCAAGCAGCTGGAAGACATGAAGGCGCTCTACCCGGACGCCGCCATCCTGGTCCACCCCGAATCGCCGGAAAGCGTGGTCGCGCTGGCCGATGCCGTGGGCTCGACCAGCCAGTTGATCAAGGCCGCGCAGACCCTGCCGAACAAGACCTTCATCGTCGCCACCGATCGCGGCATCTTCTACAAGATGCAGCAGTTGTGCCCGGACAAGGATTTCATCGAGGCCCCCACCGCCGGCAACGGCGCCGCCTGCCGCAGCTGCGCGCACTGCCCGTGGATGGCGATGAACACGCTCGAGCGGACCCTGGCCTGCCTGCGCGAGGGCAGCGGGGAAATCTTCGTCGACCCGGCGTTGATCCCGCGGGCGGTCCGTCCGCTCAAGCGCATGCTCGACTTCACCCAGGCCGCGCGCCTGCGCCAGGCCGGGAACGCCTGA
Protein Properties
Protein Residues: 352
Protein Molecular Weight: 38.4 kDa
Protein Theoretical pI: 5.4
Hydropathicity (GRAVY score): -0.037
Charge at pH 7 (predicted): -9.71
Protein Sequence: 
>PA1004
MTHISERLLVQAHLAAKQPRVLSEQESAEHRAAIAAELKAQNAVLVAHYYCDPVIQALAEETGGCVSDSLEMARFGNQHPAQTVVVAGVRFMGETAKILNPEKRVLMPTLEATCSLDLGCPVDEFSAFCDQHPERTVVVYANTSAAVKARADWVVTSSCAVEIVEHLMDNGEPILWAPDQHLGRYIQRETGADMLLWDGACIVHEEFKAKQLEDMKALYPDAAILVHPESPESVVALADAVGSTSQLIKAAQTLPNKTFIVATDRGIFYKMQQLCPDKDFIEAPTAGNGAACRSCAHCPWMAMNTLERTLACLREGSGEIFVDPALIPRAVRPLKRMLDFTQAARLRQAGNA
References
External Links:
Resource Link
Genome ID: PA1004
Entrez Gene ID: 883095
NCBI Protein ID: 15596201
General Reference: PaperBLAST - Find papers about PA1004 and its homologs