Phosphoribosylformylglycinamidine cyclo-ligase (PA0945)

Identification
Name: Phosphoribosylformylglycinamidine cyclo-ligase
Synonyms:
  • AIR synthase
  • AIRS
  • Phosphoribosyl-aminoimidazole synthetase
Gene Name: purM
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+2 Thumb+Thumb
Adenosine triphosphate + Phosphoribosylformylglycineamidine ↔ ADP + 5-Aminoimidazole ribonucleotide + 2 Hydrogen ion + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + Phosphoribosylformylglycineamidine ↔ ADP + Phosphate + 5-Aminoimidazole ribonucleotide
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Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Phosphoribosylformylglycineamidine → Hydrogen ion + ADP + Phosphate + 5-Aminoimidazole ribonucleotide
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SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Adenosine diphosphate+Thumb+Thumb
2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine triphosphate → 5-Aminoimidazole ribonucleotide + Phosphate + Adenosine diphosphate + Hydrogen ion + ADP
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+2 Thumb+Thumb
Adenosine triphosphate + Phosphoribosylformylglycineamidine ↔ ADP + 5-Aminoimidazole ribonucleotide + 2 Hydrogen ion + Phosphate
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Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Phosphoribosylformylglycineamidine → Hydrogen ion + ADP + Phosphate + 5-Aminoimidazole ribonucleotide
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + 2-(Formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine → ADP + Inorganic phosphate + 5-Aminoimidazole ribonucleotide
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0034162-(Formamido)-N(1)-(5-phospho-D-ribosyl)acetamidineMetaboCard
PAMDB0062062-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidineMetaboCard
PAMDB0003065-Aminoimidazole ribonucleotideMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000220PhosphoribosylformylglycineamidineMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
catalytic activity
cyclo-ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
phosphoribosylformylglycinamidine cyclo-ligase activity
Process
'de novo' IMP biosynthetic process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process
Gene Properties
Locus tag: PA0945
Strand: -
Entrez Gene ID: 879549
Accession: NP_249636.1
GI: 15596142
Sequence start: 1032763
Sequence End: 1033824
Sequence Length: 1061
Gene Sequence: 
>PA0945
ATGAGCAGCAAGCAACCCTCGTTGAGCTACAAGGACGCTGGTGTGGACATCGACGCCGGCGAAGCCCTGGTGGAACGCATCAAAGGCGTGGCCAAGCGCACCGCACGCCCGGAAGTGATGGGCGGCCTCGGCGGCTTCGGCGCCCTCTGCGAAATCCCGGCCGGCTACAAGCAGCCGGTGCTGGTATCCGGCACCGACGGGGTGGGCACCAAGCTGCGCCTGGCGCTCAACCTGAACAAGCACGACAGCATCGGCCAGGACCTGGTGGCGATGTGCGTCAACGACCTGGTGGTCTGCGGCGCCGAGCCGCTGTTCTTTCTCGACTACTACGCCACCGGCAAGCTCAACGTCGACGTCGCCGCCACCGTAGTCACCGGCATCGGTGCCGGTTGCGAACTGGCGGGCTGTTCCCTGGTCGGCGGCGAGACCGCCGAAATGCCCGGCATGTACGAAGGCGAAGACTATGACCTGGCCGGCTTCTGCGTCGGCGTCGTGGAAAAGGCCGAGATCATCGACGGCTCCAGGGTCCAGGCCGGCGACGCGCTTATCGCCCTGCCCTCCTCCGGCCCGCACTCCAACGGCTACTCCCTGATCCGCAAGATCATCGAGGTTTCCGGCGCCGACATCGCGCAGGTCCAACTCGACGGCAAGCCGCTGGCCGACCTGCTGATGGCGCCGACCCGCATCTACGTCAAGCCGCTGCTGCAACTGATCAAGCAGACCGGCGCGGTCAAGGCCATGGCTCACATTACCGGCGGCGGCCTGCTGGACAACATCCCGCGCGTCCTGCCGGACAACGCCCAGGCCGTGATCGATGTCGCCAGCTGGAACCGTCCGGCGGTATTCGACTGGCTGCAGGAACAGGGCAACGTCGACGAGACCGAGATGCATCGCGTACTCAACTGCGGCGTCGGCATGGTCATCTGCGTGGCCCAGAGCGACGCCGAGAAAGCCCTGGAAGTCCTGCGTGCCGCCGGCGAGCAACCCTGGCAGATCGGTCGCATCGAAACCTGCGGCGCGGACGCCGAGCGCGTGGTCCTGAACAATCTGAAAAACCACTGA
Protein Properties
Protein Residues: 353
Protein Molecular Weight: 37.1 kDa
Protein Theoretical pI: 4.54
Hydropathicity (GRAVY score): 0.12
Charge at pH 7 (predicted): -14.06
Protein Sequence: 
>PA0945
MSSKQPSLSYKDAGVDIDAGEALVERIKGVAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSRVQAGDALIALPSSGPHSNGYSLIRKIIEVSGADIAQVQLDGKPLADLLMAPTRIYVKPLLQLIKQTGAVKAMAHITGGGLLDNIPRVLPDNAQAVIDVASWNRPAVFDWLQEQGNVDETEMHRVLNCGVGMVICVAQSDAEKALEVLRAAGEQPWQIGRIETCGADAERVVLNNLKNH
References
External Links:
Resource Link
Genome ID: PA0945
Entrez Gene ID: 879549
NCBI Protein ID: 15596142
General Reference: PaperBLAST - Find papers about PA0945 and its homologs