N-acetyl-gamma-glutamyl-phosphate reductase (PA0662)

Identification
Name: N-acetyl-gamma-glutamyl-phosphate reductase
Synonyms:
  • AGPR
  • N-acetyl-glutamate semialdehyde dehydrogenase
  • NAGSA dehydrogenase
Gene Name: argC
Enzyme Class:
Biological Properties
General Function: Involved in N-acetyl-gamma-glutamyl-phosphate reductase activity
Specific Function: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH
Cellular Location: Cytoplasm (Probable)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
N-Acetyl-L-glutamate 5-semialdehyde + NADP + Phosphate ↔ N-Acetyl-L-glutamyl 5-phosphate + Hydrogen ion + NADPH
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
N-Acetyl-L-glutamate 5-semialdehyde + Phosphate + NADP ↔ N-Acetyl-L-glutamyl 5-phosphate + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+NADPH+Thumb+Thumb → N-acetyl-L-glutamate+Thumb+Thumb
N-Acetyl-L-glutamyl 5-phosphate + NADPH + Hydrogen ion + NADPH → N-acetyl-L-glutamate + Phosphate + NADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
N-Acetyl-L-glutamate 5-semialdehyde + NADP + Phosphate ↔ N-Acetyl-L-glutamyl 5-phosphate + Hydrogen ion + NADPH
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
N-Acetyl-L-glutamate 5-semialdehyde + NADP + Phosphate ↔ Hydrogen ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
N-Acetyl-L-glutamate 5-semialdehyde + NADP + Inorganic phosphate → N-Acetyl-L-glutamyl 5-phosphate + NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000675N-Acetyl-L-glutamate 5-semialdehydeMetaboCard
PAMDB000672N-Acetyl-L-glutamyl 5-phosphateMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
binding
catalytic activity
N-acetyl-gamma-glutamyl-phosphate reductase activity
NAD or NADH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
protein binding
protein dimerization activity
Process
arginine biosynthetic process
arginine metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid biosynthetic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
metabolic process
Gene Properties
Locus tag: PA0662
Strand: +
Entrez Gene ID: 882004
Accession: NP_249353.1
GI: 15595859
Sequence start: 714977
Sequence End: 716011
Sequence Length: 1034
Gene Sequence: 
>PA0662
ATGATCAAGGTCGGCATCGTTGGCGGTACGGGTTATACGGGCGTGGAACTGCTGCGCCTGCTGGCGCAGCATCCGCAGGCCCGGGTGGAAGTGATCACTTCGCGTTCCGAGGCGGGGGTGAAGGTCGCCGACATGTACCCGAACCTGCGAGGTCATTATGACGACCTGCAGTTCAGCGTGCCGGACGCGCAGCGCCTCGGCGCCTGCGACGTGGTGTTCTTCGCCACGCCGCACGGCGTGGCGCACGCGCTGGCTGGCGAACTGCTGGACGCCGGGACCCGGGTCATCGATCTGTCCGCTGACTTCCGCCTGGCGGACGCCGAGGAGTGGGCGCGCTGGTACGGCCAGCCGCATGGCGCTCCGGCGCTGCTCGACGAGGCTGTCTACGGCCTGCCGGAAGTGAACCGCGAGAAGATCCGCCAGGCCCGCCTGATCGCCGTGCCGGGCTGCTACCCGACCGCGACCCAGCTGGGCCTGATCCCGCTGCTGGAAGCCGGCCTGGCCGACGCCTCGCGGCTGATCGCCGATTGCAAGTCCGGGGTCAGCGGTGCCGGTCGGGGCGCCAAGGTTGGCTCGCTGTTCTGCGAGGCGGGCGAAAGCATGATGGCCTACGCGGTCAAAGGGCATCGGCATCTCCCGGAAATCAGCCAGGGCCTGCGTCGGGCCTCCGGCGGCGACGTCGGGCTGACGTTCGTACCGCACCTGACGCCAATGATCCGCGGTATCCATGCAACCCTCTATGCCCATGTCGCGGATCGCTCGGTCGACCTCCAGGCGTTGTTCGAGAAGCGCTACGCCGACGAACCCTTCGTCGACGTGATGCCGGCCGGCAGCCATCCGGAGACCCGCAGCGTGCGTGGCGCCAATGTCTGCCGAATCGCCGTGCATCGCCCCCAGGGCGGCGACCTGGTGGTGGTGCTGTCGGTGATCGACAACCTGGTCAAGGGCGCCTCGGGTCAGGCGCTCCAGAACATGAACATCCTGTTCGGGCTGGACGAGCGCCTGGGCCTCTCGCATGCGGCCCTGCTCCCCTGA
Protein Properties
Protein Residues: 344
Protein Molecular Weight: 36.7 kDa
Protein Theoretical pI: 6.7
Hydropathicity (GRAVY score): 0.076
Charge at pH 7 (predicted): -2.03
Protein Sequence: 
>PA0662
MIKVGIVGGTGYTGVELLRLLAQHPQARVEVITSRSEAGVKVADMYPNLRGHYDDLQFSVPDAQRLGACDVVFFATPHGVAHALAGELLDAGTRVIDLSADFRLADAEEWARWYGQPHGAPALLDEAVYGLPEVNREKIRQARLIAVPGCYPTATQLGLIPLLEAGLADASRLIADCKSGVSGAGRGAKVGSLFCEAGESMMAYAVKGHRHLPEISQGLRRASGGDVGLTFVPHLTPMIRGIHATLYAHVADRSVDLQALFEKRYADEPFVDVMPAGSHPETRSVRGANVCRIAVHRPQGGDLVVVLSVIDNLVKGASGQALQNMNILFGLDERLGLSHAALLP
References
External Links:
Resource Link
Genome ID: PA0662
Entrez Gene ID: 882004
NCBI Protein ID: 15595859
General Reference: PaperBLAST - Find papers about PA0662 and its homologs