Tryptophan biosynthesis protein trpCF (PA0651)

Identification
Name: Tryptophan biosynthesis protein trpCF
Synonyms:
  • Indole-3-glycerol phosphate synthase
  • IGPS
  • N-(5'-phospho-ribosyl)anthranilate isomerase
  • PRAI
Gene Name: trpC
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphate + Hydrogen ion ↔ Indoleglycerol phosphate + Carbon dioxide + Water
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Thumb → Thumb
N-(5-Phospho-D-ribosyl)anthranilate → 1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphate
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Thumb ↔ Thumb+Thumb+Thumb
1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphate ↔ Indoleglycerol phosphate + Carbon dioxide + Water
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SMPDB Reactions:
N-(5-phosphoribosyl)-anthranilate+Thumb → 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate+Thumb
N-(5-phosphoribosyl)-anthranilate + N-(5-phosphoribosyl)-anthranilate → 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate
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1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate+Thumb+Thumb → Thumb+Thumb
1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + Hydrogen ion + 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate → Water + Carbon dioxide
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1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate+Thumb+Thumb → Thumb+Thumb+(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate+Thumb
1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + Hydrogen ion + 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate → Water + Carbon dioxide + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
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N-(5-phosphoribosyl)-anthranilate+Thumb → Thumb
N-(5-phosphoribosyl)-anthranilate + N-(5-phosphoribosyl)-anthranilate → 1-(2-Carboxyphenylamino)-1'-deoxyribulose-5'-phosphate
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Thumb+Thumb → Thumb+Thumb+(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate+Thumb
1-(2-Carboxyphenylamino)-1'-deoxyribulose-5'-phosphate + Hydrogen ion → Carbon dioxide + Water + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphate + Hydrogen ion ↔ Indoleglycerol phosphate + Carbon dioxide + Water
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Thumb+Thumb → Thumb+Thumb+Thumb
Hydrogen ion + 1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphate → Indoleglycerol phosphate + Carbon dioxide + Water
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Thumb → Thumb
N-(5-Phospho-D-ribosyl)anthranilate → 1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphate
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Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB006317 N-(5-phosphoribosyl)-anthranilateMetaboCard
PAMDB006319(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphateMetaboCard
PAMDB0008681-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphateMetaboCard
PAMDB0018621-(2-Carboxyphenylamino)-1'-deoxyribulose-5'-phosphateMetaboCard
PAMDB0063181-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphateMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001007Indoleglycerol phosphateMetaboCard
PAMDB001021N-(5-Phospho-D-ribosyl)anthranilateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
indole-3-glycerol-phosphate synthase activity
intramolecular oxidoreductase activity
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
isomerase activity
lyase activity
phosphoribosylanthranilate isomerase activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid derivative metabolic process
cellular biogenic amine metabolic process
cellular metabolic process
indolalkylamine metabolic process
metabolic process
tryptophan metabolic process
Gene Properties
Locus tag: PA0651
Strand: +
Entrez Gene ID: 882120
Accession: NP_249342.1
GI: 15595848
Sequence start: 705130
Sequence End: 705966
Sequence Length: 836
Gene Sequence: 
>PA0651
GTGAGTGTGCCGACGGTTCTGCAGAAGATCCTCGCCCGCAAGGCCGAGGAGGTCGCCGAGCGCCGTGCGCGCGTCAACCTGGCAGAGGTCGAGCGGCTGGCGCGTAGCGCCGATGCGCCGCGCGGCTTCGCCAATGCCCTGCTGGAGCGGGCCAAGCGCAAGGAGCCGGCAGTGATCGCCGAGATCAAGAAGGCATCGCCGAGCAAGGGCGTGCTGCGCGAACACTTCGTCCCGGCGGAGATCGCCCGCAGCTACGAGGCGGGTGGCGCGGCGTGCCTGTCGGTGCTCACCGACGTGGACTTCTTCCAGGGCGCCGATGCCTATCTGAAGGAAGCGCGGGCCGCCTGTGCGCTGCCGGTGATCCGCAAGGACTTCATGATCGATCCGTACCAGATCGTCGAGGCGCGGGCGATCGGTGCCGACTGCATCCTGCTGATCGTCTCGGCGCTGGACGACGTGCTGATGGCCGAACTGGCGGCGACTGCCAAGTCGGTCGGTCTCGACGTACTGGTCGAAGTGCATGACGGCACCGAGCTGGAACGTGCACTGAAGACCCTGGACACGCCGTTGGTGGGCATCAACAACCGCAACCTGCACACCTTCGAGGTGAGCCTGGAAACCACCCTCGACCTGTTGCCGGAAATTCCCCGCGACCGCCTGGTGGTCACCGAGAGCGGTATTCTCAACCGGGCCGACGTGGAGCTGATGGAAGTCAGCGAGGTCTACGCCTTCCTGGTTGGCGAGGCGTTCATGCGGGCCGACGATCCTGGCCTCGAGCTGAAGCGCCTGTTCTTCCAGGAGCGTGGTGCTGTGGTGCTGGGCGCCGATCCTGACTGA
Protein Properties
Protein Residues: 278
Protein Molecular Weight: 30.3 kDa
Protein Theoretical pI: 4.64
Hydropathicity (GRAVY score): 0.112
Charge at pH 7 (predicted): -11.35
Protein Sequence: 
>PA0651
MSVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQERGAVVLGADPD
References
External Links:
Resource Link
Genome ID: PA0651
Entrez Gene ID: 882120
NCBI Protein ID: 15595848
General Reference: PaperBLAST - Find papers about PA0651 and its homologs