Aspartate carbamoyltransferase catalytic chain (PA0402)

Identification
Name: Aspartate carbamoyltransferase catalytic chain
Synonyms:
  • Aspartate transcarbamylase
  • ATCase
Gene Name: pyrB
Enzyme Class:
Biological Properties
General Function: Involved in carboxyl- or carbamoyltransferase activity
Specific Function: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Aspartic acid + Carbamoylphosphate ↔ Ureidosuccinic acid + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Carbamoylphosphate + L-Aspartic acid ↔ Phosphate + Ureidosuccinic acid
ReactionCard
SMPDB Reactions:
L-Aspartic acid+Thumb → Thumb
L-Aspartic acid + L-Aspartic acid → N-carbamoyl-L-aspartate
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Thumb+L-Aspartic acid+Thumb → Thumb+Thumb+Thumb
Carbamoylphosphate + L-Aspartic acid + L-Aspartic acid → Phosphate + Hydrogen ion + N-carbamoyl-L-aspartate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Aspartic acid + Carbamoylphosphate ↔ Ureidosuccinic acid + Hydrogen ion + Phosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Carbamoylphosphate + L-Aspartic acid → Inorganic phosphate + Ureidosuccinic acid
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000253CarbamoylphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000080L-Aspartic acidMetaboCard
PAMDB006306N-carbamoyl-L-aspartateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000189Ureidosuccinic acidMetaboCard
GO Classification:
Function
amino acid binding
aspartate carbamoyltransferase activity
binding
carboxyl- or carbamoyltransferase activity
carboxylic acid binding
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
Process
'de novo' pyrimidine base biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular aromatic compound metabolic process
cellular metabolic process
metabolic process
nucleobase metabolic process
pyrimidine base biosynthetic process
pyrimidine base metabolic process
Gene Properties
Locus tag: PA0402
Strand: -
Entrez Gene ID: 878267
Accession: NP_249093.1
GI: 15595599
Sequence start: 444687
Sequence End: 445691
Sequence Length: 1004
Gene Sequence: 
>PA0402
ATGCCGACAGACGCCAAGCGCCCGCTGCAGCTCAACGACCAGGGCCAGCTGCGCCACTTCATCTCGCTCGACGGATTGCCCCGCGAGCTGCTCACCGAAATCCTCGATACCGCCGATTCCTTCCTGGAGGTCGGCGCCCGCGCGGTGAAAAAGGTCCCGCTGCTGCGCGGCAAGACCGTCTGCAACGTGTTCTTCGAGAACTCCACGCGCACCCGCACCACCTTCGAGCTGGCCGCCCAGCGGCTGTCGGCCGACGTGATCAGCCTGAACGTATCCACCTCTTCCACCAGCAAGGGCGAGACGCTCACCGACACCCTGCGCAACCTGGAGGCGATGGCCGCCGACATGTTCGTGGTGCGCCACAGCGACTCGGGCGCGGCGCACTTCATCGCCGAGCACGTCAGCCCCAACGTGGCGGTGATCAACGGCGGCGACGGACGCCACGCGCACCCCACCCAGGGGATGCTCGACATGCTGACCATCCGCCGGCACAAAGGGAACTTCGAGCAGCTATCGGTGGCGATCGTCGGCGATATCCTGCATTCGCGAGTAGCCCGTTCGAACATGCTGGCGCTCAAGACCCTGGGTTGCCCGGACATCCGCGTGATCGCCCCGCGCACCCTCTTGCCGATCGGCCTGGAAGAGCAGTACGGCGTGCGCGTGTTCACCAACGCCGACGAAGGCCTGAAGGACGTCGACGTGGTGATCATGCTGCGCCTGCAACGCGAGCGCATGCAGGGTGGCCTGCTACCCAGCGAGGGCGAGTTCTTCAAGCTCTACGGCCTGACCGAGAAGCGCCTGAAGCTGGCCAAGCCGGATGCCATCGTCATGCACCCTGGCCCGATCAACCGTGGCGTGGAGATCGAGTCGGCGGTGGCCGACGGGGCCCAGTCGGTGATCCTCAACCAGGTCACCTACGGCATCGCCATCCGCATGGCGGTGCTGTCCATGGCCATGAGCGGCCAGAACACCCAACGCCAGCTGGAACAGGAGGACGCCGAATGA
Protein Properties
Protein Residues: 334
Protein Molecular Weight: 36.6 kDa
Protein Theoretical pI: 6.8
Hydropathicity (GRAVY score): -0.114
Charge at pH 7 (predicted): -0.89
Protein Sequence: 
>PA0402
MPTDAKRPLQLNDQGQLRHFISLDGLPRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFELAAQRLSADVISLNVSTSSTSKGETLTDTLRNLEAMAADMFVVRHSDSGAAHFIAEHVSPNVAVINGGDGRHAHPTQGMLDMLTIRRHKGNFEQLSVAIVGDILHSRVARSNMLALKTLGCPDIRVIAPRTLLPIGLEEQYGVRVFTNADEGLKDVDVVIMLRLQRERMQGGLLPSEGEFFKLYGLTEKRLKLAKPDAIVMHPGPINRGVEIESAVADGAQSVILNQVTYGIAIRMAVLSMAMSGQNTQRQLEQEDAE
References
External Links:
Resource Link
Genome ID: PA0402
Entrez Gene ID: 878267
NCBI Protein ID: 15595599
General Reference: PaperBLAST - Find papers about PA0402 and its homologs