4-aminobutyrate aminotransferase (PA0266)

Identification
Name: 4-aminobutyrate aminotransferase
Synonyms:
  • (S)-3-amino-2-methylpropionate transaminase
  • GABA aminotransferase
  • GABA-AT
  • Gamma-amino-N-butyrate transaminase
  • GABA transaminase
  • Glutamate:succinic semialdehyde transaminase
  • L-AIBAT
Gene Name: gabT
Enzyme Class:
Biological Properties
General Function: Involved in 4-aminobutyrate transaminase activity
Specific Function: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
gamma-Aminobutyric acid + alpha-Ketoglutarate ↔ L-Glutamate + Succinic acid semialdehyde
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
beta-Alanine + alpha-Ketoglutarate ↔ Malonic semialdehyde + L-Glutamate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
gamma-Aminobutyric acid + alpha-Ketoglutarate ↔ Succinic acid semialdehyde + L-Glutamate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
(S)-b-aminoisobutyric acid + alpha-Ketoglutarate ↔ (S)-Methylmalonic acid semialdehyde + L-Glutamate
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+L-Glutamic acid+Thumb
gamma-Aminobutyric acid + Oxoglutaric acid → Succinic acid semialdehyde + L-Glutamic acid + L-Glutamate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
gamma-Aminobutyric acid + Oxoglutaric acid ↔ L-Glutamate + Succinic acid semialdehyde
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
gamma-Aminobutyric acid + Oxoglutaric acid → Succinic acid semialdehyde + L-Glutamate
ReactionCard
Thumb+Thumb → Thumb+Thumb
gamma-Aminobutyric acid + Oxoglutaric acid → Succinic acid semialdehyde + L-Glutamate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
(S)-b-aminoisobutyric acid + Oxoglutaric acid → 2-Methyl-3-oxopropanoate + L-Glutamate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000445(S)-b-aminoisobutyric acidMetaboCard
PAMDB000448(S)-Methylmalonic acid semialdehydeMetaboCard
PAMDB0035162-Methyl-3-oxopropanoateMetaboCard
PAMDB000466alpha-KetoglutarateMetaboCard
PAMDB000019beta-AlanineMetaboCard
PAMDB000561gamma-Aminobutyric acidMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000474Malonic semialdehydeMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
PAMDB000313Succinic acid semialdehydeMetaboCard
GO Classification:
Function
4-aminobutyrate transaminase activity
binding
catalytic activity
cofactor binding
pyridoxal phosphate binding
transaminase activity
transferase activity
transferase activity, transferring nitrogenous groups
Process
cellular amino acid and derivative metabolic process
cellular amino acid derivative metabolic process
cellular metabolic process
gamma-aminobutyric acid metabolic process
metabolic process
Gene Properties
Locus tag: PA0266
Strand: +
Entrez Gene ID: 880917
Accession: NP_248957.1
GI: 15595463
Sequence start: 301218
Sequence End: 302498
Sequence Length: 1280
Gene Sequence: 
>PA0266
ATGAGCAAGACCAACGAATCCCTGCTGAAGCGTCGCCAGGCCGCGGTACCCCGCGGCGTGGGCCAGATCCACCCGGTCGTCGCCGAGCGCGCCGAGAACTCCACCGTCTGGGACGTGGAAGGCCGCGAGTACATCGACTTCGCCGGCGGCATCGCCGTGCTGAACACCGGCCACCTGCATCCGAAGGTGATCGCCGCGGTCCAAGAGCAACTGGGCAAGCTGTCCCACACCTGCTTCCAGGTGCTGGCCTACGAACCCTACATCGAGCTGGCCGAGGAAATCGCCAAGCGCGTGCCGGGCGACTTCCCGAAGAAGACCCTGCTGGTCACCTCCGGCTCCGAAGCCGTGGAGAACGCCGTCAAGATCGCCCGCGCCGCCACCGGCCGCGCTGGCGTGATCGCCTTCACCGGCGCGTACCACGGCCGCACCATGATGACCCTGGGCCTGACCGGCAAGGTGGTCCCGTACTCCGCCGGCATGGGCCTGATGCCGGGCGGCATCTTCCGCGCCCTGGCGCCCTGCGAGCTGCACGGCGTGAGCGAGGACGACTCCATCGCCAGCATCGAGCGCATCTTCAAGAACGATGCCCAGCCCCAGGACATCGCCGCGATCATCATCGAGCCGGTGCAGGGCGAGGGTGGCTTCTACGTCAACTCCAAGTCCTTCATGCAGCGCCTGCGCGCCCTGTGCGACCAGCACGGCATCCTGCTGATCGCCGACGAAGTGCAGACCGGCGCCGGCCGTACCGGCACCTTCTTCGCTACCGAGCAACTGGGCATCGTTCCTGACCTGACCACCTTCGCCAAGTCGGTCGGCGGCGGCTTCCCGATCTCCGGCGTGGCCGGCAAGGCCGAGATCATGGACGCCATCGCGCCCGGCGGCCTGGGCGGCACCTATGCCGGCAGCCCGATCGCCTGCGCCGCGGCACTGGCCGTGCTGAAGGTGTTCGAGGAAGAGAAGCTGTTGGAACGTTCGCAAGCCGTCGGCGAGCGCCTCAAGGCCGGCCTGCGCGAGATCCAGGCCAAGCACAAGGTGATCGGCGACGTTCGTGGCCTGGGTTCGATGGTGGCCATCGAGCTGTTCGAGGGCGGCGATACCCACAAGCCGGCCGCCGAGCTGGTCAGCAAGATCGTCGTCCGTGCGCGCGAGAAGGGCCTGATCCTGCTCTCCTGCGGCACCTACTACAACGTCATCCGCTTCCTCATGCCCGTCACCATCCCCGACGCGCAACTGGAGAAGGGCCTGGCCATCCTGGCCGAGTGCTTCGACGAACTCGCTTAA
Protein Properties
Protein Residues: 426
Protein Molecular Weight: 45.2 kDa
Protein Theoretical pI: 6.43
Hydropathicity (GRAVY score): 0.142
Charge at pH 7 (predicted): -3
Protein Sequence: 
>PA0266
MSKTNESLLKRRQAAVPRGVGQIHPVVAERAENSTVWDVEGREYIDFAGGIAVLNTGHLHPKVIAAVQEQLGKLSHTCFQVLAYEPYIELAEEIAKRVPGDFPKKTLLVTSGSEAVENAVKIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGMGLMPGGIFRALAPCELHGVSEDDSIASIERIFKNDAQPQDIAAIIIEPVQGEGGFYVNSKSFMQRLRALCDQHGILLIADEVQTGAGRTGTFFATEQLGIVPDLTTFAKSVGGGFPISGVAGKAEIMDAIAPGGLGGTYAGSPIACAAALAVLKVFEEEKLLERSQAVGERLKAGLREIQAKHKVIGDVRGLGSMVAIELFEGGDTHKPAAELVSKIVVRAREKGLILLSCGTYYNVIRFLMPVTIPDAQLEKGLAILAECFDELA
References
External Links:
Resource Link
Genome ID: PA0266
Entrez Gene ID: 880917
NCBI Protein ID: 15595463
General Reference: PaperBLAST - Find papers about PA0266 and its homologs