Coproporphyrinogen-III oxidase, aerobic (PA0024)

Identification
Name: Coproporphyrinogen-III oxidase, aerobic
Synonyms:
  • Coprogen oxidase
  • Coproporphyrinogenase
Gene Name: hemF
Enzyme Class:
Biological Properties
General Function: Involved in coproporphyrinogen oxidase activity
Specific Function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+2 Thumb+Thumb ↔ 2 Thumb+2 Thumb+Thumb
Coproporphyrin III + 2 Hydrogen ion + Oxygen ↔ 2 Carbon dioxide + 2 Water + Protoporphyrinogen IX
ReactionCard
Thumb+Thumb ↔ Thumb+2 Thumb+2 Thumb
Coproporphyrin III + Oxygen ↔ Protoporphyrinogen IX + 2 Carbon dioxide + 2 Water
ReactionCard
SMPDB Reactions:
Thumb+2 Thumb+Thumb → 2 Thumb+2 Thumb+Thumb
Coproporphyrinogen III + 2 Hydrogen ion + Oxygen → 2 Water + 2 Carbon dioxide + Protoporphyrinogen IX
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+2 Thumb → Thumb+2 Thumb+2 Thumb
Coproporphyrinogen III + Oxygen + 2 Hydrogen ion → Protoporphyrinogen IX + 2 Carbon dioxide + 2 Water
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000568Carbon dioxideMetaboCard
PAMDB000151Coproporphyrin IIIMetaboCard
PAMDB000314Coproporphyrinogen IIIMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000624OxygenMetaboCard
PAMDB000254Protoporphyrinogen IXMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
coproporphyrinogen oxidase activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
Process
metabolic process
nitrogen compound metabolic process
oxidation reduction
porphyrin biosynthetic process
porphyrin metabolic process
tetrapyrrole metabolic process
Gene Properties
Locus tag: PA0024
Strand: +
Entrez Gene ID: 880901
Accession: NP_248714.1
GI: 15595222
Sequence start: 25736
Sequence End: 26653
Sequence Length: 917
Gene Sequence: 
>PA0024
GTGACCGACCGTATCGCCGCTGTCAAAACCTACCTGCTCGACCTGCAAGACCGCATCTGCGCCGCCCTCGAGGCGGAGGACGGCAAGGCCCGCTTCGCCGAGGACGCCTGGGAGCGTCCGGCCGGTGGCGGCGGACGGACGCGGGTAATCGGCGACGGCGCATTGATCGAGAAGGGCGGGGTGAATTTTTCCCACGTCTTCGGCGATAGCCTGCCGCCCTCGGCCAGCGCCCATCGGCCGGAACTGGCCGGGCGCGGTTTCCAGGCGCTCGGCGTGTCGCTGGTGATCCATCCGGAAAACCCCCACGTGCCGACGTCCCATGCCAACGTGCGTTTCTTCTGCGCCGAGAAGGAAGGCGAGGAGCCGGTCTGGTGGTTCGGCGGCGGCTTCGATCTGACCCCCTACTACGCCCACGAGGAAGACTGCGTGCATTGGCACCGGGTCGCTCGCGACGCCTGCGCGCCGTTCGGCGCGGACGTCTACCCGCGCTACAAGGAATGGTGCGACCGCTACTTCCACCTCAAGCACCGCAACGAGCCGCGCGGCATCGGCGGCCTGTTCTTCGACGACCTCAACCAGTGGGACTTCGACACCTGCTTCGCCTTCATCCGCGCCATCGGCGATGCCTATATCGACGCCTACCTGCCGATCGTCCAGCGCCGCAAGCACACGCCGTTCGATGAACGGCAGCGAGAGTTCCAGGCCTATCGTCGCGGTCGCTATGTGGAGTTCAACCTGGTCTTCGATCGTGGCACCCTGTTCGGCCTGCAGTCCGGCGGCCGTACCGAATCGATCCTGATGTCGTTGCCGCCGCAGGTGCGCTGGGGCTATGACTGGAAACCCGAGCCGGGCAGCGAGGAAGCGCGCCTGACCGAGTATTTCCTCGCCGACCGCGATTGGCTCGCCGGCCAGCCCTGA
Protein Properties
Protein Residues: 305
Protein Molecular Weight: 34.8 kDa
Protein Theoretical pI: 5.78
Hydropathicity (GRAVY score): -0.507
Charge at pH 7 (predicted): -7.53
Protein Sequence: 
>PA0024
MTDRIAAVKTYLLDLQDRICAALEAEDGKARFAEDAWERPAGGGGRTRVIGDGALIEKGGVNFSHVFGDSLPPSASAHRPELAGRGFQALGVSLVIHPENPHVPTSHANVRFFCAEKEGEEPVWWFGGGFDLTPYYAHEEDCVHWHRVARDACAPFGADVYPRYKEWCDRYFHLKHRNEPRGIGGLFFDDLNQWDFDTCFAFIRAIGDAYIDAYLPIVQRRKHTPFDERQREFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKPEPGSEEARLTEYFLADRDWLAGQP
References
External Links:
Resource Link
Genome ID: PA0024
Entrez Gene ID: 880901
NCBI Protein ID: 15595222
General Reference: PaperBLAST - Find papers about PA0024 and its homologs