Reaction Details
Reaction: Thumb
an isocitrate dehydrogenase + ATP ↔ a phosphorylated isocitrate dehydrogenase + ADP
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:PHOSICITDEHASE-RXN
References:
  • Miller SP, Karschnia EJ, Ikeda TP, LaPorte DC (1996). "Isocitrate dehydrogenase kinase/phosphatase. Kinetic characteristics of the wild-type and two mutant proteins." J Biol Chem 271(32);19124-8. PMID: 8702587
  • Oudot C, Cortay JC, Blanchet C, Laporte DC, Di Pietro A, Cozzone AJ, Jault JM (2001). "The "catalytic" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases." Biochemistry 40(10);3047-55. PMID: 11258918
  • Singh SK, Matsuno K, LaPorte DC, Banaszak LJ (2001). "Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase." J Biol Chem 276(28);26154-63. PMID: 11290745
  • Stueland CS, Ikeda TP, LaPorte DC (1989). "Mutation of the predicted ATP binding site inactivates both activities of isocitrate dehydrogenase kinase/phosphatase." J Biol Chem 264(23);13775-9. PMID: 2547774
  • Wang JY, Koshland DE (1982). "The reversible phosphorylation of isocitrate dehydrogenase of Salmonella typhimurium." Arch Biochem Biophys 218(1);59-67. PMID: 6756316
  • Zheng J, Jia Z (2010). "Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase." Nature 465(7300);961-5. PMID: 20505668