| Identification |
| Name: |
Isocitrate dehydrogenase kinase/phosphatase |
| Synonyms: |
- IDH kinase/phosphatase
- IDHK/P
|
| Gene Name: |
aceK |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in [isocitrate dehydrogenase (NADP+)] kinase activity |
| Specific Function: |
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
Not Available |
| KEGG Reactions: |
|
 | + | [Isocitrate dehydrogenase (NADP+)] | ↔ |  | + | [Isocitrate dehydrogenase (NADP+)] phosphate |
| |
|
| SMPDB Reactions: |
Not Available |
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | [isocitrate dehydrogenase (NADP(+))] | → | | + | [isocitrate dehydrogenase (NADP(+))] phosphate |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| catalytic activity | | hydrolase activity | | hydrolase activity, acting on ester bonds | | kinase activity | | phosphatase activity | | phosphoric ester hydrolase activity | | protein kinase activity | | transferase activity | | transferase activity, transferring phosphorus-containing groups | | [isocitrate dehydrogenase (NADP+)] kinase activity | | Process |
|---|
| alcohol metabolic process | | glucose metabolic process | | hexose metabolic process | | metabolic process | | monosaccharide metabolic process | | small molecule metabolic process |
|
| Gene Properties |
| Locus tag: |
PA1376 |
| Strand: |
- |
| Entrez Gene ID: |
881156 |
| Accession: |
NP_250067.1 |
| GI: |
15596573 |
| Sequence start: |
1493090 |
| Sequence End: |
1494823 |
| Sequence Length: |
1733 |
| Gene Sequence: |
>PA1376
ATGGTCCAGAGCGCCCCAGCCAGCGAAATCGCCGCCCTCATCCTGCGCGGTTTCGACGATTACCGAGAGCAGTTCCGCGAGATCACCGACGGCGCCCGTGCCCGCTTCGAGCAGGCGCAGTGGCAGGAAGCGCAGCGCGCCTCGGCGCAGCGGATCAACCTCTACGAGGAAAAGGTCGCCGAGACGGTGGCCGGGCTGCGCGCGGGGCTGGCCGACAGCGAGCTGCTGGACGTGGAGCGCTGGCCGATCATCAAGAGCGCCTACATCGCGCAGATCGACTTGCGGCTGGACGACGAGCTGGCCGAGACCTGGTTCAACTCGATCTTCTGCGGGCTGTTCAGCCACGACAACATCAGCGACGGCACGATGTTCGTGCACACCACCCGGCCCTCGCTGCGCGCCCACGCCCGCGCGCCCTACACCCGCACCTACCGGCCGGGCGGCGACCTGCGCCAGGCGCTGGAGAAGATCTTCGACGACTACCGCTTCGACGTGCCCTACGACGACCGCGAGCGCGACCTCGAACGGATCGACGCACTGCTGCACAGCAACCTGCCGGACTGGGTGTGCAAGGACCCGGACCTGGCCATCGAGCTGATCGGCTCGGTGTTCTATCGCAACAAGGGCGCCTACCTGGTGGGCCGCCTGTTCACCCCGGACGAGCAGTGGCCGCTGGTGTTCCCGCTGCTGCACCGCGAGGACCACGGCATCCAGTTCGACACGGTGATCACCGACGAGGCGGAAGTCTCGATCATCTTCTCCTTCACCCGCTCCTACTTCATGGTCGACGTGCCGGTGCCGGCCGAGCTGGTGGCCTTCCTCAAGCGCCTGCTGCCGGGCAAGCACCTGGCCGAGCTGTACACGTCGATCGGCTTCTACAAGCAGGGCAAGAGCGAGTTCTACCGCGCCCTAATCAACCACCTGGCGACCACCGACGACCGCTTCGTCATGGCCCCCGGCGTGCGCGGCATGGTGATGAGCGTGTTCACCCTGCCCGGCTTCAACACGGTGTTCAAGATCATCAAGGACCGCTTCAACCCTTCGAAGAGCGTCGACCACGCCACGGTGATCCAGAAGTACCAGTTGGTGAAGAACCACGACCGGGTCGGACGCCTGGCCGACACCCAGCAGTTCGCCGACTTCCGCTTCCCGGTGAGCAAGTTCGAGCCGGAGTGCCTGGCCGAACTGCTGGAAGTGGCGCCGTCGACGGTGGTGATGGAAGGCGACGTGGTGCTGATCCGCCACTGCTGGACGGAGCGGCGCATGACCCCACTGAACATCTACCTGGAGAACGCCAGCGAGGCGCAGACCCGCGAGGCGCTGAACGACTACGGGCTGGCGATCAAGCAACTGGCGGCGGCGAACATCTTCCCCGGCGACATGCTGCTGAAGAACTTCGGCGTGACCCGCCATGGCCGGGTGGTGTTCTACGACTACGACGAGATCTGCTACCTCACCGAGGTGAACTTCCGCTACATCCCCGAGCCGCGCTTCCCCGAGGACGAGATGTCGTCCGAGCCCTGGTATTCGGTGGGGCCCAACGACGTGTTCCCGGAAGAATTCCCGCGCTTCCTGTTCGTCGACCTCAACCAGCGCCGGCTATTCGCCAAGCTGCACGGCAACCTCTACGACGCCAAATACTGGCAGGGCCTGCAGGAGCAGATCCGCGAGGGCAAGGTGATCGACGTGTTTCCCTATCGGCGGCAGGAGACGCCCGAGCAGTTGCTCGGGTAG |
| Protein Properties |
| Protein Residues: |
577 |
| Protein Molecular Weight: |
66.8 kDa |
| Protein Theoretical pI: |
4.98 |
| Hydropathicity (GRAVY score): |
-0.301 |
| Charge at pH 7 (predicted): |
-17.99 |
| Protein Sequence: |
>PA1376
MVQSAPASEIAALILRGFDDYREQFREITDGARARFEQAQWQEAQRASAQRINLYEEKVAETVAGLRAGLADSELLDVERWPIIKSAYIAQIDLRLDDELAETWFNSIFCGLFSHDNISDGTMFVHTTRPSLRAHARAPYTRTYRPGGDLRQALEKIFDDYRFDVPYDDRERDLERIDALLHSNLPDWVCKDPDLAIELIGSVFYRNKGAYLVGRLFTPDEQWPLVFPLLHREDHGIQFDTVITDEAEVSIIFSFTRSYFMVDVPVPAELVAFLKRLLPGKHLAELYTSIGFYKQGKSEFYRALINHLATTDDRFVMAPGVRGMVMSVFTLPGFNTVFKIIKDRFNPSKSVDHATVIQKYQLVKNHDRVGRLADTQQFADFRFPVSKFEPECLAELLEVAPSTVVMEGDVVLIRHCWTERRMTPLNIYLENASEAQTREALNDYGLAIKQLAAANIFPGDMLLKNFGVTRHGRVVFYDYDEICYLTEVNFRYIPEPRFPEDEMSSEPWYSVGPNDVFPEEFPRFLFVDLNQRRLFAKLHGNLYDAKYWQGLQEQIREGKVIDVFPYRRQETPEQLLG |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA1376 and its homologs
|
