Reaction Details
Reaction: Thumb
anthraniloyl-CoA + 3-oxodecanoate + H+ → 2-heptyl-4(1H)-quinolone + CO2 + coenzyme A + H2O
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:RXN-11848
References:
  • Bera AK, Atanasova V, Robinson H, Eisenstein E, Coleman JP, Pesci EC, Parsons JF (2009). "Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate." Biochemistry 48(36);8644-55. PMID: 19694421
  • Pistorius D, Ullrich A, Lucas S, Hartmann RW, Kazmaier U, Muller R (2011). "Biosynthesis of 2-Alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity." Chembiochem 12(6);850-3. PMID: 21425231
  • Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Musken M, Haussler S, Steinbach A, Hartmann RW (2012). "Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors." J Am Chem Soc 134(39);16143-6. PMID: 22992202
  • Zhang YM, Frank MW, Zhu K, Mayasundari A, Rock CO (2008). "PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa." J Biol Chem 283(43);28788-94. PMID: 18728009