Reaction 21729

Reaction Details
Reaction: Thumb
tetrahydrobiopterin + L-phenylalanine + oxygen → L-tyrosine + 4α-hydroxy-tetrahydrobiopterin
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:PHENYLALANINE-4-MONOOXYGENASE-RXN
References:
  • Andersen OA, Flatmark T, Hough E (2001). "High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin." J Mol Biol 314(2);279-91. PMID: 11718561
  • Carr RT, Balasubramanian S, Hawkins PC, Benkovic SJ (1995). "Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase." Biochemistry 34(22);7525-32. PMID: 7779797
  • Erlandsen H, Kim JY, Patch MG, Han A, Volner A, Abu-Omar MM, Stevens RC (2002). "Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates." J Mol Biol 320(3);645-61. PMID: 12096915
  • Guroff G, Rhoads CA (1969). "Phenylalanine hydroxylation by Pseudomonas species (ATCC 11299a). Nature of the cofactor." J Biol Chem 244(1);142-6. PMID: 5773277
  • KAUFMAN S (1959). "Studies on the mechanism of the enzymatic conversion of phenylalanine to tyrosine." J Biol Chem 234;2677-82. PMID: 14404870
  • MITOMA C (1956). "Studies on partially purified phenylalanine hydroxylase." Arch Biochem Biophys 60(2);476-84. PMID: 13292928
  • UDENFRIEND S, COOPER JR (1952). "The enzymatic conversion of phenylalanine to tyrosine." J Biol Chem 194(2);503-11. PMID: 14927641