Reaction 21610

Reaction Details
Reaction: Thumb
pyruvate + L-aspartate-semialdehyde → (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:DIHYDRODIPICSYN-RXN
References:
  • Blickling S, Renner C, Laber B, Pohlenz HD, Holak TA, Huber R (1997). "Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy." Biochemistry 36(1);24-33. PMID: 8993314
  • Devenish SR, Blunt JW, Gerrard JA (2010). "NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase." J Med Chem 53(12);4808-12. PMID: 20503968
  • Soares da Costa TP, Muscroft-Taylor AC, Dobson RC, Devenish SR, Jameson GB, Gerrard JA (2010). "How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?." Biochimie 92(7);837-45. PMID: 20353808
  • Yugari Y, Gilvarg C (1965). "The condensation step in diaminopimelate synthesis." J Biol Chem 240(12);4710-6. PMID: 5321309