Reaction Details
Reaction: Thumb
D-ribulose 5-phosphate → formate + 1-deoxy-L-glycero-tetrulose 4-phosphate + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:DIOHBUTANONEPSYN-RXN
References:
  • Echt S, Bauer S, Steinbacher S, Huber R, Bacher A, Fischer M (2004). "Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans." J Mol Biol 341(4);1085-96. PMID: 15328619
  • Fischer M, Romisch W, Schiffmann S, Kelly M, Oschkinat H, Steinbacher S, Huber R, Eisenreich W, Richter G, Bacher A (2002). "Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii." J Biol Chem 277(44);41410-6. PMID: 12200440
  • Kelly MJ, Ball LJ, Krieger C, Yu Y, Fischer M, Schiffmann S, Schmieder P, Kuhne R, Bermel W, Bacher A, Richter G, Oschkinat H (2001). "The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site." Proc Natl Acad Sci U S A 98(23);13025-30. PMID: 11687623
  • Liao DI, Calabrese JC, Wawrzak Z, Viitanen PV, Jordan DB (2001). "Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis." Structure 9(1);11-8. PMID: 11342130
  • Liao DI, Zheng YJ, Viitanen PV, Jordan DB (2002). "Structural definition of the active site and catalytic mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase." Biochemistry 41(6);1795-806. PMID: 11827524
  • Steinbacher S, Schiffmann S, Richter G, Huber R, Bacher A, Fischer M (2003). "Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism." J Biol Chem 278(43);42256-65. PMID: 12904291
  • Steinbacher S, Schiffmann S, Bacher A, Fischer M (2004). "Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate." Acta Crystallogr D Biol Crystallogr 60(Pt 7);1338-40. PMID: 15213409
  • Volk R, Bacher A (1990). "Studies on the 4-carbon precursor in the biosynthesis of riboflavin. Purification and properties of L-3,4-dihydroxy-2-butanone-4-phosphate synthase." J Biol Chem 265(32);19479-85. PMID: 2246238