Reaction 21585

Reaction Details
Reaction: Thumb
2-C-methyl-D-erythritol 4-phosphate + NADP+ ← 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:DXPREDISOM-RXN
References:
  • Munos JW, Pu X, Mansoorabadi SO, Kim HJ, Liu HW (2009). "A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement." J Am Chem Soc 131(6);2048-9. PMID: 19159292
  • Takahashi S, Kuzuyama T, Watanabe H, Seto H (1998). "A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis." Proc Natl Acad Sci U S A 95(17);9879-84. PMID: 9707569