Reaction Details
Reaction: Thumb
2-iminosuccinate + glycerone phosphate → quinolinate + phosphate + 2 H2O
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:QUINOLINATE-SYNTHA-RXN
References:
  • Katoh A, Uenohara K, Akita M, Hashimoto T (2006). "Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid." Plant Physiol 141(3);851-7. PMID: 16698895
  • Ollagnier-de Choudens S, Loiseau L, Sanakis Y, Barras F, Fontecave M (2005). "Quinolinate synthetase, an iron-sulfur enzyme in NAD biosynthesis." FEBS Lett 579(17);3737-43. PMID: 15967443
  • Rousset C, Fontecave M, Ollagnier de Choudens S (2008). "The [4Fe-4S] cluster of quinolinate synthase from Escherichia coli: Investigation of cluster ligands." FEBS Lett 582(19);2937-44. PMID: 18674537
  • Sakuraba H, Tsuge H, Yoneda K, Katunuma N, Ohshima T (2005). "Crystal structure of the NAD biosynthetic enzyme quinolinate synthase." J Biol Chem 280(29);26645-8. PMID: 15937336
  • Saunders AH, Booker SJ (2008). "Regulation of the activity of Escherichia coli quinolinate synthase by reversible disulfide-bond formation." Biochemistry 47(33);8467-9. PMID: 18651751