Reaction 21325

Reaction Details
Reaction: Thumb
adenosyl-cobyrinate a,c-diamide + 4 L-glutamine + 4 ATP + 4 H2O → 4 L-glutamate + adenosylcobyrate + 4 ADP + 4 phosphate + 4 H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:R345-RXN
References:
  • Blanche F, Couder M, Debussche L, Thibaut D, Cameron B, Crouzet J (1991). "Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans." J Bacteriol 173(19);6046-51. PMID: 1917839
  • Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)." Nat Prod Rep 19(4);390-412. PMID: 12195810