Identification
Name: cobyric acid synthase
Synonyms: cbiP
Gene Name: cobQ
Enzyme Class: Not Available
Biological Properties
General Function: cobalamin biosynthetic process
Specific Function: catalytic activity, adenosylcobyric acid synthase (glutamine-hydrolyzing) activity
Cellular Location: Cytoplasmic
KEGG Pathways:
  • adenosylcobalamin biosynthesis II (late cobalt incorporation) P381-PWY
  • adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I PWY-5509
  • adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II PWY-5508
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb
    adenosyl-cobyrinate a,c-diamide + 4 L-glutamine + 4 ATP + 4 H2O → 4 L-glutamate + adenosylcobyrate + 4 ADP + 4 phosphate + 4 H+
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites: Not Available
    GO Classification:
    Function
    catalytic activity
    adenosylcobyric acid synthase (glutamine-hydrolyzing) activity
    Process
    cobalamin biosynthetic process
    Gene Properties
    Locus tag: PA1277
    Strand: +
    Entrez Gene ID: 881421
    Accession: NP_249968.1
    GI: 15596474
    Sequence start: 1388242
    Sequence End: 1389714
    Sequence Length: 1472
    Gene Sequence:
    >PA1277
    ATGAGTGATCGCGGGCGGACCCTGATGGTCCAGGGCACCACCTCGGACGCCGGCAAGAGCACCCTGGTGACCGCGCTGTGCCGCTGGCTGGCCCGGCGCGGCGTCGCGGTGGTGCCGTTCAAGCCGCAGAACATGGCGCTGAACAGCGCGGTCACCGCCGACGGCGGCGAGATCGGCCGCGCCCAGGCGGTCCAGGCCCAGGCCTGTCGGCTGGCGCCGCACACCGACATGAACCCGGTGCTGCTCAAGCCGAACACCGACATCGGCGCCCAGGTGATCATCCATGGCCGCGCGGTGACCAGCATGGACGCCGCCGCCTACCACGACTACAAGCGCGTGGCGATGGAAGCGGTGCTGGCTTCCCATGGGCGGCTCGCCGCCGCCTACCGGGTGGTGATGGTGGAGGGCGCCGGCTCGCCGGCGGAGATCAACCTGCGCGCCAACGACATCGCCAACATGGGCTTCGCCGAAGCGGTGGATTGCCCGGTGATCCTGGTCGCCGATATCGACCGCGGCGGGGTCTTCGCCCACCTGGTCGGCACCCTGGAACTGCTCTCCGACTCGGAGCGGGAGCGGGTCAAGGGCTTCGTCATCAATCGCTTCCGCGGCGACATCGCCCTGCTGCAACCCGGCCTCGACTGGCTGGAGGCGCGCACCGGCAAGCCGGTGCTCGGCGTGCTGCCCTATGTCAGCGACCTGCACCTGGAGGCGGAGGACGCCATCGACACGCGCCAGGCGGCCAAGGTCGGGCCGCGCCTGAAGGTGGTGGTGCCGGTGCTGCCGAGGATCAGCAACCACACCGATTTCGATCCGCTGCGCCTGCACCCCCAGGTCGAGTTGAGCTTCGTCGGCCCCGGCCAGGCGCTGCCGTCGGCGGACCTGATCGTCCTGCCCGGCTCGAAGAGCGTGCGCGCCGACCTCGCGGCGCTGCGCGAGCGTGGCTGGGACGAGGCGATCCTCCGTCACCTGCGCTACGGCGGTCGCCTGCTGGGGATCTGCGGCGGCCTGCAGATGCTCGGCGAGCGCCTGCACGATCCGCTCGGCCTGGAAGGCGCGGCCGGCAGCAGCGCTGGCCTCGGCCTGCTGGCGTTGGAAACGACCCTGGAGGCGGACAAGCAATTGCGCAACGTACAGGGCCGCCTGAGCCTGGAGGATGCGCCGCTGTCGGGCTACGAGATCCATGCCGGAGTCACCCGTGGCGAAGCCCTGGCGCGGCCGGCGGTGGTGCTCGACGATGGCCGCGCGGATGGTGCCCGCAGCGTCGACGGGAACGTCATGGGCACCTACCTGCACGGCCTGTTCGAATCCACCGCGGCCTGTTCGGCGCTGCTGCGCTGGGCCGGCCTGCGCGAGGTCCAGGCGGTGGACTACCAGGCCTTGCGCGAACGCGACATCGAGCGGCTCGCCGACCTGGTCGAGCGCCACCTGGATACCGGGCGATTGCTCGCCCTCTGCGGAGAACCCCATGCGTGA
    Protein Properties
    Protein Residues: 490
    Protein Molecular Weight: 52.4 kDa
    Protein Theoretical pI: 6.4
    Hydropathicity (GRAVY score): 0.012
    Charge at pH 7 (predicted): -4.79
    Protein Sequence:
    >PA1277
    MSDRGRTLMVQGTTSDAGKSTLVTALCRWLARRGVAVVPFKPQNMALNSAVTADGGEIGRAQAVQAQACRLAPHTDMNPVLLKPNTDIGAQVIIHGRAVTSMDAAAYHDYKRVAMEAVLASHGRLAAAYRVVMVEGAGSPAEINLRANDIANMGFAEAVDCPVILVADIDRGGVFAHLVGTLELLSDSERERVKGFVINRFRGDIALLQPGLDWLEARTGKPVLGVLPYVSDLHLEAEDAIDTRQAAKVGPRLKVVVPVLPRISNHTDFDPLRLHPQVELSFVGPGQALPSADLIVLPGSKSVRADLAALRERGWDEAILRHLRYGGRLLGICGGLQMLGERLHDPLGLEGAAGSSAGLGLLALETTLEADKQLRNVQGRLSLEDAPLSGYEIHAGVTRGEALARPAVVLDDGRADGARSVDGNVMGTYLHGLFESTAACSALLRWAGLREVQAVDYQALRERDIERLADLVERHLDTGRLLALCGEPHA
    References
    External Links:
    Resource Link
    Genome ID: PA1277
    Entrez Gene ID: 881421
    NCBI Protein ID: 15596474
    General Reference: PaperBLAST - Find papers about PA1277 and its homologs