Reaction Details
Reaction: Thumb
glutaryl-CoA + an oxidized electron-transfer flavoprotein + 2 H+ = crotonyl-CoA + CO2 + a reduced electron-transfer flavoprotein
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:GLUTARYL-COA-DEHYDROGENASE-RXN
References:
  • Besrat A, Polan CE, Henderson LM (1969). "Mammalian metabolism of glutaric acid." J Biol Chem 244(6);1461-7. PMID: 4304226
  • Dwyer TM, Zhang L, Muller M, Marrugo F, Frerman F (1999). "The functions of the flavin contact residues, alphaArg249 and betaTyr16, in human electron transfer flavoprotein." Biochim Biophys Acta 1433(1-2);139-52. PMID: 10446367
  • Hartel U, Eckel E, Koch J, Fuchs G, Linder D, Buckel W (1993). "Purification of glutaryl-CoA dehydrogenase from Pseudomonas sp., an enzyme involved in the anaerobic degradation of benzoate." Arch Microbiol 1993;159(2);174-81. PMID: 8439237
  • Rao KS, Albro M, Dwyer TM, Frerman FE (2006). "Kinetic mechanism of glutaryl-CoA dehydrogenase." Biochemistry 45(51);15853-61. PMID: 17176108