Reaction 21049

Reaction Details
Reaction: Thumb
4-methyl-5-(2-phosphonooxyethyl)thiazole + 4-amino-2-methyl-5-diphosphomethylpyrimidine + H+ → thiamin phosphate + diphosphate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:THI-P-SYN-RXN
References:
  • Ajjawi I, Tsegaye Y, Shintani D (2007). "Determination of the genetic, molecular, and biochemical basis of the Arabidopsis thaliana thiamin auxotroph th1." Arch Biochem Biophys 459(1);107-14. PMID: 17174261
  • Camiener GW, BrownN GM (1960). "The biosynthesis of thiamine. 2. Fractionation of enzyme system and identification of thiazole monophosphate and thiamine monophosphate as intermediates." J Biol Chem 235;2411-7. PMID: 13807175
  • Chiu HJ, Reddick JJ, Begley TP, Ealick SE (1999). "Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution." Biochemistry 38(20);6460-70. PMID: 10350464
  • Kawasaki Y (1993). "Copurification of hydroxyethylthiazole kinase and thiamine-phosphate pyrophosphorylase of Saccharomyces cerevisiae: characterization of hydroxyethylthiazole kinase as a bifunctional enzyme in the thiamine biosynthetic pathway." J Bacteriol 175(16);5153-8. PMID: 8394314
  • Leder IG (1961). "The enzymatic synthesis of thiamine monophosphate." J Biol Chem 236;3066-71. PMID: 14463407