Reaction Details
Reaction: Thumb
oxaloacetate + acetyl-CoA + H2O → citrate + coenzyme A + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:CITSYN-RXN
References:
  • Belova LL, Sokolov AP, Morgunov IG, Trotsenko YuA (1997). "Purification and characterization of citrate synthase from Methylobacterium extorquens--a methylotrophic producer of polyhydroxybutyrate." Biochemistry (Mosc) 62(1);71-6. PMID: 9113733
  • Karpusas M, Branchaud B, Remington SJ (1990). "Proposed mechanism for the condensation reaction of citrate synthase: 1.9-A structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme A." Biochemistry 29(9);2213-9. PMID: 2337600
  • Krebs HA, Johnson WA (1980). "The role of citric acid in intermediate metabolism in animal tissues." FEBS Lett 117 Suppl;K1-10. PMID: 6998725
  • Kurz LC, Shah S, Frieden C, Nakra T, Stein RE, Drysdale GR, Evans CT, Srere PA (1995). "Catalytic strategy of citrate synthase: subunit interactions revealed as a consequence of a single amino acid change in the oxaloacetate binding site." Biochemistry 34(41);13278-88. PMID: 7577912
  • Lee S, Park C, Yim J (1997). "Characterization of citrate synthase purified from Drosophila melanogaster." Mol Cells 7(5);599-604. PMID: 9387145
  • Lohlein-Werhahn G, Goepfert P, Eggerer H (1988). "Purification and properties of an archaebacterial enzyme: citrate synthase from Sulfolobus solfataricus." Biol Chem Hoppe Seyler 369(2);109-13. PMID: 3130075
  • Maurus R, Nguyen NT, Stokell DJ, Ayed A, Hultin PG, Duckworth HW, Brayer GD (2003). "Insights into the evolution of allosteric properties. The NADH binding site of hexameric type II citrate synthases." Biochemistry 42(19);5555-65. PMID: 12741811
  • Sievers M, Stockli M, Teuber M (1997). "Purification and properties of citrate synthase from Acetobacter europaeus." FEMS Microbiol Lett 146(1);53-8. PMID: 8997706