Reaction 21044

Reaction Details
Reaction: Thumb
a thiopurine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + a thiopurine S-methylether + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:THIOPURINE-S-METHYLTRANSFERASE-RXN
References:
  • REMY CN (1963). "Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues." J Biol Chem 238;1078-84. PMID: 13981612
  • Woodson LC, Ames MM, Selassie CD, Hansch C, Weinshilboum RM (1983). "Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives." Mol Pharmacol 24(3);471-8. PMID: 6633508
  • Woodson LC, Weinshilboum RM (1983). "Human kidney thiopurine methyltransferase. Purification and biochemical properties." Biochem Pharmacol 32(5);819-26. PMID: 6838629