Reaction 21030

Reaction Details
Reaction: Thumb
a 5,10-methylene-tetrahydrofolate + dUMP → dTMP + a 7,8-dihydrofolate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:THYMIDYLATESYN-RXN
References:
  • Lockshin A, Moran RG, Danenberg PV (1979). "Thymidylate synthetase purified to homogeneity from human leukemic cells." Proc Natl Acad Sci U S A 76(2);750-4. PMID: 34155
  • Slavik K, Slavikova V (1980). "Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography." Methods Enzymol 66;709-23. PMID: 6990200
  • Wahba AJ, Friedkin M (1962). "The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli." J Biol Chem 237;3794-801. PMID: 13998281