Identification
Name: DNA helicase II
Synonyms: Not Available
Gene Name: uvrD
Enzyme Class:
Biological Properties
General Function: Replication, recombination and repair
Specific Function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair
Cellular Location: Cytoplasmic
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
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    Complex Reactions:
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    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB000148Adenosine triphosphateMetaboCard
    PAMDB000345ADPMetaboCard
    PAMDB001776Inorganic phosphateMetaboCard
    PAMDB000142WaterMetaboCard
    GO Classification:
    Component
    cell part
    cytoplasm
    intracellular part
    Function
    adenyl nucleotide binding
    adenyl ribonucleotide binding
    ATP binding
    ATP-dependent DNA helicase activity
    binding
    catalytic activity
    DNA binding
    DNA helicase activity
    helicase activity
    hydrolase activity
    hydrolase activity, acting on acid anhydrides
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    nucleic acid binding
    nucleoside binding
    nucleoside-triphosphatase activity
    purine nucleoside binding
    pyrophosphatase activity
    Process
    cellular macromolecule metabolic process
    cellular process
    DNA conformation change
    DNA duplex unwinding
    DNA geometric change
    DNA metabolic process
    DNA repair
    DNA unwinding involved in replication
    macromolecule metabolic process
    metabolic process
    Gene Properties
    Locus tag: PA5443
    Strand: +
    Entrez Gene ID: 877766
    Accession: NP_254130.1
    GI: 15600636
    Sequence start: 6131088
    Sequence End: 6133274
    Sequence Length: 2186
    Gene Sequence:
    >PA5443
    ATGAACGACGACCTCTCCCTCCTGCTGAACTCCCTCAACGACCCGCAGCGCCAGGCCGTGGCCGCGCCGCTGGGCCGCCAACTGGTCCTCGCCGGCGCCGGCTCGGGCAAGACCCGCGTGCTGGTGCACCGGATCGCCTGGCTGATCCAGGTCGAGCACGCCTCGCCCTACAGCATCCTGTCGGTGACCTTCACCAACAAGGCGGCGGCGGAGATGCGCCACCGCATCGAGCAGTTGCTCGGGATCAATCCGGCGGGCATGTGGGTCGGCACCTTCCACGGCCTCGCCCATCGCCTGCTGCGCGCGCACTGGCGCGAGGCCGGGCTGAGCGAGAACTTCCAGATCCTCGACAGCGACGACCAGCAACGCCTGGTCAAGCGGGTGATCCGCGAACTCGGCCTCGACGAGCAGCGCTGGCCGGCGCGCCAGGCCCAGTGGTTCATCAACGGGCAGAAGGACGAGGGCCTGCGGCCGCAACACATCCAGCCCGGCGGCGACCTGTTCCTCGCCACCATGCTGAAGATCTACGAAGCCTACGAGGCGGCCTGCGCCCGCGCCGGGGTGATCGACTTCTCCGAGCTGCTGCTGCGCGCCCTGGACCTCTGGCGCGACCATCCCGGCGTGCTCGAGCACTACCAGCGGCGCTTCCGCCATATCCTGGTGGACGAGTTCCAGGACACCAACGCCGTGCAATACGCCTGGCTGCGGATTCTCGCCAAGGGCGGCGACAGCCTGATGGTGGTCGGCGACGACGACCAGTCGATCTACGGCTGGCGTGGCGCACGGATCGAGAACATCCAGCAGTTCAGCGACGACTTCGCCGATGCCGAGGTGATCCGCCTGGAGCAGAACTACCGTTCCACCGCGTCGATCCTCAAGGCCGCCAACGCCCTGATCGCCAACAACCAGGGACGCCTGGGCAAGGAGTTGTGGACCGACGGCGAGGACGGCGAGTCGCTGAGCCTGTACGCCGCGTTCAACGAGCACGACGAGGCGCGCTACGTGGTCGAGTCGATCGAGAGCGCGCTCAAGGGCGGCCTGGCGCGCAGCGAGATCGCCATCCTCTACCGCTCCAACGCCCAGTCGCGGGTGCTGGAGGAAGCCCTGCTGCGGGAGAAGATTCCCTACCGCATCTACGGCGGCCAGCGCTTCTTCGAGCGTGCCGAGATCAAGAACGCCATGGCCTACCTGCGCCTGCTCGACGGCCGCGGCAACGACGCGGCGCTGGAACGGGTGGTCAACGTGCCGGCACGCGGCATCGGCGAGAAGACCGTGGAGAGCATCCGCGAATTCGCCCGCGGCAACGATGTGTCGATGTGGGAGGCGATCCGCCTGATGATCGCCAACAAGGTCCTGCCCGGCCGCGCCGCCAGCGCCCTGACCGGCTTCGTCGAGCTGATCGAGAATCTTTCGGCGAAGGTCATGGACATGCCGCTGCACCTGATGACCCAGACGGTGATCGAGCAGTCCGGACTGATCAGCTACCACAAGGAAGAAAAAGGCGAGAAAGGCCAGGCCCGGGTGGAGAACCTCGAGGAACTGGTCAGCGCCGCCCGCGCCTTCGAGAACAGCGAGGAAGAGGAAGACCTCACCCCGCTGCAGGCCTTCCTCAGCCACGCCTCCCTGGAGGCCGGGGAAACCCAGGCCGACGCCCACGAGGACAGTGTCCAGCTGATGACCCTGCACAGCGCCAAGGGCCTGGAGTTCCCGCTGGTGTTCCTGGTCGGCATGGAGGAAGGGCTGTTCCCGCACAAGATGAGCCTGGAGGAATCCGGCCGCCTGGAAGAGGAACGCCGCCTGGCCTACGTCGGCGTCACCCGCGCCATGCAGCGACTGGTCCTGACCTACGCGGAGACCCGCCGGCTCTACGGTAGCGAGACCTACAACAAGGTTTCGCGCTTCATCCGCGAGATCCCGCCGGCGCTGATCCAGGAAGTGCGCCTGTCCAATACCGTCAGCCGCCCCTACGGCGGCACCTCGCGCAGTGCCGGCGGCAACCTCTTCAGCGGCGCCGGGGTGCCGGAGACGCCCTTCTCCCTCGGCCAGCGGGTGCGCCACGCGCTGTTCGGCGAAGGGACTATCCTCAACTTCGAAGGCGCCGGCGCCCAGGCCCGGGTGCAGGTGAATTTCGAGAGCGAAGGCAGCAAGTGGCTGATGCTCGGCTACGCCAAGCTGGAAGCCCTGTAG
    Protein Properties
    Protein Residues: 728
    Protein Molecular Weight: 81.5 kDa
    Protein Theoretical pI: 5.67
    Hydropathicity (GRAVY score): -0.283
    Charge at pH 7 (predicted): -13.64
    Protein Sequence:
    >PA5443
    MNDDLSLLLNSLNDPQRQAVAAPLGRQLVLAGAGSGKTRVLVHRIAWLIQVEHASPYSILSVTFTNKAAAEMRHRIEQLLGINPAGMWVGTFHGLAHRLLRAHWREAGLSENFQILDSDDQQRLVKRVIRELGLDEQRWPARQAQWFINGQKDEGLRPQHIQPGGDLFLATMLKIYEAYEAACARAGVIDFSELLLRALDLWRDHPGVLEHYQRRFRHILVDEFQDTNAVQYAWLRILAKGGDSLMVVGDDDQSIYGWRGARIENIQQFSDDFADAEVIRLEQNYRSTASILKAANALIANNQGRLGKELWTDGEDGESLSLYAAFNEHDEARYVVESIESALKGGLARSEIAILYRSNAQSRVLEEALLREKIPYRIYGGQRFFERAEIKNAMAYLRLLDGRGNDAALERVVNVPARGIGEKTVESIREFARGNDVSMWEAIRLMIANKVLPGRAASALTGFVELIENLSAKVMDMPLHLMTQTVIEQSGLISYHKEEKGEKGQARVENLEELVSAARAFENSEEEEDLTPLQAFLSHASLEAGETQADAHEDSVQLMTLHSAKGLEFPLVFLVGMEEGLFPHKMSLEESGRLEEERRLAYVGVTRAMQRLVLTYAETRRLYGSETYNKVSRFIREIPPALIQEVRLSNTVSRPYGGTSRSAGGNLFSGAGVPETPFSLGQRVRHALFGEGTILNFEGAGAQARVQVNFESEGSKWLMLGYAKLEAL
    References
    External Links:
    Resource Link
    Genome ID: PA5443
    Entrez Gene ID: 877766
    NCBI Protein ID: 15600636
    General Reference: PaperBLAST - Find papers about PA5443 and its homologs