Thioredoxin-1 (PA5240)

Identification
Name: Thioredoxin-1
Synonyms:
  • Trx-1
Gene Name: trxA
Enzyme Class: Not Available
Biological Properties
General Function: Involved in electron carrier activity
Specific Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions
Cellular Location: Not Available
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Complex Reactions:
    Thumb+Reduced Thioredoxin → Thumb+Thumb+Oxidized Thioredoxin
    ADP + Reduced Thioredoxin → dADP + Water + Oxidized Thioredoxin
    ReactionCard
    Thumb+Reduced Thioredoxin → Thumb+Thumb+Oxidized Thioredoxin
    Guanosine diphosphate + Reduced Thioredoxin → dGDP + Water + Oxidized Thioredoxin
    ReactionCard
    Thumb+Reduced Thioredoxin → Thumb+Thumb+Oxidized Thioredoxin
    CDP + Reduced Thioredoxin → dCDP + Water + Oxidized Thioredoxin
    ReactionCard
    Reduced Thioredoxin+Thumb → Thumb+Thumb+Oxidized Thioredoxin
    Reduced Thioredoxin + Uridine 5'-diphosphate → dUDP + Water + Oxidized Thioredoxin
    ReactionCard
    Thumb+Reduced Thioredoxin → Thumb+Thumb+Oxidized Thioredoxin
    Methionine sulfoxide + Reduced Thioredoxin → Water + L-Methionine + Oxidized Thioredoxin
    ReactionCard
    Thumb+Reduced Thioredoxin → 2 Thumb+Oxidized Thioredoxin
    Hydrogen peroxide + Reduced Thioredoxin → 2 Water + Oxidized Thioredoxin
    ReactionCard
    Thumb+Reduced Thioredoxin → 2 Thumb+Thumb+Thumb+Oxidized Thioredoxin
    Phosphoadenosine phosphosulfate + Reduced Thioredoxin → 2 Hydrogen ion + Adenosine 3',5'-diphosphate + Sulfite + Oxidized Thioredoxin
    ReactionCard
    Thumb+Thumb+Oxidized Thioredoxin → Thumb+Reduced Thioredoxin
    Hydrogen ion + NADPH + Oxidized Thioredoxin → NADP + Reduced Thioredoxin
    ReactionCard
    fused thiol:disulfide interchange protein (oxidized)+Reduced Thioredoxin → fused thiol:disulfide interchange protein (reduced)+Oxidized Thioredoxin
    fused thiol:disulfide interchange protein (oxidized) + Reduced Thioredoxin → fused thiol:disulfide interchange protein (reduced) + Oxidized Thioredoxin
    ReactionCard
    Thumb+Reduced Thioredoxin → Thumb+Thumb+Oxidized Thioredoxin
    Methionine sulfoxide + Reduced Thioredoxin → Water + L-Methionine + Oxidized Thioredoxin
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB000022Adenosine 3',5'-diphosphateMetaboCard
    PAMDB000345ADPMetaboCard
    PAMDB000415CDPMetaboCard
    PAMDB001728dADPMetaboCard
    PAMDB000307dCDPMetaboCard
    PAMDB000209dGDPMetaboCard
    PAMDB000221dUDPMetaboCard
    PAMDB000296Guanosine diphosphateMetaboCard
    PAMDB001633Hydrogen ionMetaboCard
    PAMDB001640Hydrogen peroxideMetaboCard
    PAMDB000175L-MethionineMetaboCard
    PAMDB000428Methionine sulfoxideMetaboCard
    PAMDB000089NADPMetaboCard
    PAMDB000615NADPHMetaboCard
    PAMDB000269Phosphoadenosine phosphosulfateMetaboCard
    PAMDB001689SelenodiglutathioneMetaboCard
    PAMDB000100SulfiteMetaboCard
    PAMDB000123Uridine 5'-diphosphateMetaboCard
    PAMDB000142WaterMetaboCard
    GO Classification:
    Function
    catalytic activity
    disulfide oxidoreductase activity
    electron carrier activity
    oxidoreductase activity
    oxidoreductase activity, acting on a sulfur group of donors
    protein disulfide oxidoreductase activity
    Process
    cell redox homeostasis
    cellular homeostasis
    cellular process
    glycerol ether metabolic process
    metabolic process
    organic ether metabolic process
    small molecule metabolic process
    Gene Properties
    Locus tag: PA5240
    Strand: -
    Entrez Gene ID: 877946
    Accession: NP_253927.1
    GI: 15600433
    Sequence start: 5900369
    Sequence End: 5900695
    Sequence Length: 326
    Gene Sequence: 
    >PA5240
ATGAGCGAACATATCGTCAACGTTACTGATGCCAGCTTCGAGCAGGACGTGCTGAAGGCCGACGGCCCTGTGCTGGTGGACTACTGGGCCGAGTGGTGCGGTCCGTGCAAGATGATCGCGCCGGTGCTGGACGAAGTCGCCAGGGACTATCAGGGCAAGCTGAAGGTCTGCAAGCTGAACATCGACGAGAACCAGGATACCCCGCCGAAATACGGCGTGCGTGGCATCCCTACCCTGATGCTGTTCAAGGACGGCAATGTCGAGGCGACCAAGGTCGGCGCACTGTCCAAGTCGCAGCTGGCGGCCTTCCTCGACGCCAATATCTGA
    Protein Properties
    Protein Residues: 108
    Protein Molecular Weight: 11.9 kDa
    Protein Theoretical pI: 4.47
    Hydropathicity (GRAVY score): -0.117
    Charge at pH 7 (predicted): -4.86
    Protein Sequence: 
    >PA5240
MSEHIVNVTDASFEQDVLKADGPVLVDYWAEWCGPCKMIAPVLDEVARDYQGKLKVCKLNIDENQDTPPKYGVRGIPTLMLFKDGNVEATKVGALSKSQLAAFLDANI
    References
    External Links:
    Resource Link
    Genome ID: PA5240
    Entrez Gene ID: 877946
    NCBI Protein ID: 15600433
    General Reference: PaperBLAST - Find papers about PA5240 and its homologs