Glycine dehydrogenase [decarboxylating] (PA5213)

Identification
Name: Glycine dehydrogenase [decarboxylating]
Synonyms:
  • Glycine cleavage system P-protein
  • Glycine decarboxylase
Gene Name: gcvP
Enzyme Class:
Biological Properties
General Function: Involved in glycine dehydrogenase (decarboxylating) activity
Specific Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Lipoylprotein ↔ S-Aminomethyldihydrolipoylprotein+Thumb
Glycine + Lipoylprotein ↔ S-Aminomethyldihydrolipoylprotein + Carbon dioxide
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Lipoylprotein ↔ S-Aminomethyldihydrolipoylprotein+Thumb
Glycine + Lipoylprotein ↔ S-Aminomethyldihydrolipoylprotein + Carbon dioxide
ReactionCard
Thumb+H-protein-lipoyllysine → H-protein-S-aminomethyldihydrolipoyllysine+Thumb
Glycine + H-protein-lipoyllysine → H-protein-S-aminomethyldihydrolipoyllysine + Carbon dioxide
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Glycine + NAD + Tetrahydrofolic acid → Carbon dioxide + 5,10-Methylene-THF + NADH + Ammonium
ReactionCard
Thumb+H-protein-lipoyllysine → H-protein-S-aminomethyldihydrolipoyllysine+Thumb
Glycine + H-protein-lipoyllysine → H-protein-S-aminomethyldihydrolipoyllysine + Carbon dioxide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0003535,10-Methylene-THFMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB000046GlycineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000424Tetrahydrofolic acidMetaboCard
GO Classification:
Function
binding
catalytic activity
cofactor binding
glycine dehydrogenase (decarboxylating) activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-NH2 group of donors
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
pyridoxal phosphate binding
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glycine metabolic process
metabolic process
oxidation reduction
serine family amino acid metabolic process
Gene Properties
Locus tag: PA5213
Strand: -
Entrez Gene ID: 880606
Accession: NP_253900.1
GI: 15600406
Sequence start: 5868181
Sequence End: 5871057
Sequence Length: 2876
Gene Sequence: 
>PA5213
ATGTCGCAGACGCCGTCCCTCGCCCAGCTCCAGCCCGCCGATGCCTTCCTGCGCCGCCATCTCGGCCCCGATCCTGCGGAACAGCAGGCCATGCTGGCCTTCCTCGGAGTTTCCACTCGCGCCGAACTGATCGTGCAGACGGTGCCGCCGGCGATCCGCCTCAACCGGCCGCTGGAACTGCCCGCCGCGCTCGACGAACAGGCCGCCCTGGCGCGCCTGCGCGGCTACGCCGGGCTCAACCAGCGCTGGACCAGCCTGATCGGCATGGGCTACTACGGCACCGTGACGCCGTCGGTGATCCTCCGCAACGTGCTGGAGAATCCCGGCTGGTACACCGCCTATACGCCCTACCAGCCGGAAATCGCCCAGGGCCGCCTGGAAGCGCTGCTGAATTTCCAGCAACTGACCATCGACCTCACCGGACTCGACCTGGCCAGCGCCTCGCTGCTCGACGAAGCCACCGCCGCCGCCGAGGCCATGGCCCTGGCCAGGCGGGTGGCAAAGGCCAGGAGCAACCGGTTCTTCGTCGATGCGCATTGCCATCCGCAGACCGTTTCGGTGTTGCGTACCCGCGCCGAGGCGTTCGGTTTCGAGCTGGTCGTCGACGAGCCGGACAATCTTGCCGCCCACGCGGTGTTCGGCGCCTTGCTGCAATACCCGGACAGTCGCGGCGAGATCCGCGACCTGCGCCCGCTTATCGAGGCGTTGCACGGCCAACAGGCGCTGGCTTGCGTCGCCAGCGACCTGCTCGCCCTGTTGTTGCTGACCCCGCCGGGGGAACTCGGTGCCGACGTGGTGCTCGGCAGCGCCCAGCGCTTTGGCGTACCGATGGGCTACGGCGGGCCGCACGCGGCGTTCTTCGCCACCCGCGAAGGGTACAAGCGGGCAATGCCGGGGCGGATCATCGGCGTTTCCCGCGACGCCCGCGGCAACCCGGCGTTGCGCATGGCCCTGCAAACCCGCGAGCAGCACATCCGTCGGGAAAAGGCCAACTCGAACATCTGCACCGCCCAGGTGCTGCTGGCCAACATTGCTTCGCTGTATGCCGTCTACCATGGGCCACAGGAGCTGAAACGCATCGCCCAACGCGTCCAGCGCCTGACCGCGCTGCTGGCGGCGGGCCTGAAAAGCAAGGGACTGCGGCGGCTCAACCGGCACTTCTTCGACACCCTGACCTACGAGGTCGGCGAGCGTCAGGCGGCGATCCTCGAACGGGCGCGGGCGGCACGGGTCAACCTGCGCGTGGTCGACGACCGGCGGCTGGCCCTGAGCCTCGACGAAACCTGTGACGCGGCGACCCTGGCGACCCTGTTCGAGATCTTCCTCGGCGCCGGCCACGGGCTGGATGTCGCGCACCTGGATGGCGGGGCGGTGGCCGACGGCATCCCGGCGGTCCTGCAACGCACTTCGGCCTACCTGCAGCATCCGGTGTTCAACGCCCACCACAGCGAGACCGAGATGCTTCGCTACCTGCGCCAGCTGGAAGGCAAGGACCTGGCGCTGAACCAGGCGATGATCCCGCTCGGCTCCTGCACCATGAAGCTCAACGCCAGCAGCGAAATGATCCCCATCACCTGGCCGGAATTCGCCGAACTGCATCCGTTCGTGCCGCGCGAGCAGGCCGAGGGCTATCGCCGGATGATCGACGAACTGGAAGCCTGGCTGCGGGCGATCACCGGCTTCGACGCCATCTGCATGCAGCCGAACTCGGGAGCACAGGGCGAATATGCCGGGTTGCTGGCGATCCGCCGCTACCACCAGAGCCGCGGCGATAGCCAGCGCGACATCTGCCTGATCCCCGCATCGGCGCATGGCACCAACCCGGCCTCGGCGATCATGGCCAGCATGCGGGTGGTGATCGTCGAGTGCGATCCCCGCGGCAACGTCGACCTCGACGACCTGCGCCTCAAGGCGGCCGAGGCGGGCGACCGGCTGTCCTGCCTGATGATCACCTATCCCTCGACCCACGGCGTCTACGAAGAGGGGATAGGCGAGATCTGCGAAGTGGTCCACCGCCACGGCGGCCAGGTCTACATGGACGGCGCCAACCTCAACGCCCAGGTCGGCCTGGCGCGACCGGCGGACATCGGCGCGGACGTCTCGCACATGAACCTGCACAAGACCTTCTGCATCCCCCATGGTGGTGGCGGGCCGGGCATGGGGCCGATCGGGGTCAAGCGGCACCTGGCGCCGTTCGTCGCCAACCATCCGGTGATCCGCGTCGAAGGGCCGAACCCGCTGAACGACGCGGTCAGCGCGACGCCCTGGGGCAGCGCCAGCATCCTGCCGATCAGTTGGATGTACATCGCCATGATGGGCCCGCAGCTGGCCGACGCCAGCGAGGTGGCGATCCTCTCCGCCAACTACCTGGCGAACCGCCTGGACGGGGCGTTCCCGGTGCTCTACCGCGGGCGCAACGAGCGCGTCGCCCACGAATGCATCCTCGACCTGCGACCGCTCAAGGCGCAGACCGGGATAACCGAGGAAGACGTGGCCAAGCGCCTGATGGACTACGGCTTCCACGCCCCGACCATGTCCTTCCCGGTGCCGGGCACGCTGATGGTGGAGCCGACCGAGAGCGAGTCGAAGGCGGAGCTGGATCGCTTCGTCGAGGCGATGCTGAGCATCAGGGCCGAGATCGGCAAGGTGGAGAGCGGCGCCTGGCCGGCGGAGGACAACCCGCTGAAACGGGCGCCGCATACCCTGGCCGACGTCACCGGGATCTGGCAGAGACCCTACGAGATCGCCGAGGCAGTGACCCCGAGCGAACATGCGCGGGCGTTCAAGTACTGGCCGGCGGTTAACCGGGTGGACAACGTCTACGGCGACCGCAACCTGTTCTGCGCCTGCGTGCCGCTGGACGACTACCGCGAGTGA
Protein Properties
Protein Residues: 958
Protein Molecular Weight: 104.7 kDa
Protein Theoretical pI: 6.48
Hydropathicity (GRAVY score): -0.098
Charge at pH 7 (predicted): -8.4
Protein Sequence: 
>PA5213
MSQTPSLAQLQPADAFLRRHLGPDPAEQQAMLAFLGVSTRAELIVQTVPPAIRLNRPLELPAALDEQAALARLRGYAGLNQRWTSLIGMGYYGTVTPSVILRNVLENPGWYTAYTPYQPEIAQGRLEALLNFQQLTIDLTGLDLASASLLDEATAAAEAMALARRVAKARSNRFFVDAHCHPQTVSVLRTRAEAFGFELVVDEPDNLAAHAVFGALLQYPDSRGEIRDLRPLIEALHGQQALACVASDLLALLLLTPPGELGADVVLGSAQRFGVPMGYGGPHAAFFATREGYKRAMPGRIIGVSRDARGNPALRMALQTREQHIRREKANSNICTAQVLLANIASLYAVYHGPQELKRIAQRVQRLTALLAAGLKSKGLRRLNRHFFDTLTYEVGERQAAILERARAARVNLRVVDDRRLALSLDETCDAATLATLFEIFLGAGHGLDVAHLDGGAVADGIPAVLQRTSAYLQHPVFNAHHSETEMLRYLRQLEGKDLALNQAMIPLGSCTMKLNASSEMIPITWPEFAELHPFVPREQAEGYRRMIDELEAWLRAITGFDAICMQPNSGAQGEYAGLLAIRRYHQSRGDSQRDICLIPASAHGTNPASAIMASMRVVIVECDPRGNVDLDDLRLKAAEAGDRLSCLMITYPSTHGVYEEGIGEICEVVHRHGGQVYMDGANLNAQVGLARPADIGADVSHMNLHKTFCIPHGGGGPGMGPIGVKRHLAPFVANHPVIRVEGPNPLNDAVSATPWGSASILPISWMYIAMMGPQLADASEVAILSANYLANRLDGAFPVLYRGRNERVAHECILDLRPLKAQTGITEEDVAKRLMDYGFHAPTMSFPVPGTLMVEPTESESKAELDRFVEAMLSIRAEIGKVESGAWPAEDNPLKRAPHTLADVTGIWQRPYEIAEAVTPSEHARAFKYWPAVNRVDNVYGDRNLFCACVPLDDYRE
References
External Links:
Resource Link
Genome ID: PA5213
Entrez Gene ID: 880606
NCBI Protein ID: 15600406
General Reference: PaperBLAST - Find papers about PA5213 and its homologs