Acetylornithine deacetylase (PA5206)

Identification
Name: Acetylornithine deacetylase
Synonyms:
  • AO
  • Acetylornithinase
  • N-acetylornithinase
  • NAO
Gene Name: argE
Enzyme Class:
Biological Properties
General Function: Involved in zinc ion binding
Specific Function: Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde
Cellular Location: Cytoplasm (Probable)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
N-Acetylornithine + Water ↔ Acetic acid + Ornithine + L-Ornithine
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
N-Acetylornithine + Water ↔ Acetic acid + Ornithine
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N-Acetyl-L-citrulline+Thumb ↔ Thumb+Thumb
N-Acetyl-L-citrulline + Water ↔ Acetic acid + Citrulline
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SMPDB Reactions:
N-acetyl-L-glutamate+L-Glutamic acid+Thumb → Thumb+Thumb
N-acetyl-L-glutamate + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + N-Acetylornithine
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Thumb+Thumb → Thumb+L-Ornithine monochlorohydrate/ornithine
N-Acetylornithine + Water → Acetic acid + L-Ornithine monochlorohydrate/ornithine
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Thumb+Thumb → Ornithine+Thumb+Thumb
N-Acetylornithine + Water → Ornithine + Acetic acid + Ornithine
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
N-Acetylornithine + Water ↔ Acetic acid + Ornithine + L-Ornithine
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
N-Acetyl-L-glutamate 5-semialdehyde + Water → Acetic acid + L-Glutamic-gamma-semialdehyde
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Thumb+Thumb → Thumb+Thumb
N-Acetylornithine + Water → Acetic acid + Ornithine
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000012Acetic acidMetaboCard
PAMDB000198CitrullineMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000331L-Glutamic-gamma-semialdehydeMetaboCard
PAMDB005689L-OrnithineMetaboCard
PAMDB000675N-Acetyl-L-glutamate 5-semialdehydeMetaboCard
PAMDB000493N-AcetylornithineMetaboCard
PAMDB000087OrnithineMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
acetylornithine deacetylase activity
binding
catalytic activity
cation binding
cobalt ion binding
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
ion binding
metal ion binding
metallopeptidase activity
peptidase activity
peptidase activity, acting on L-amino acid peptides
protein binding
transition metal ion binding
zinc ion binding
Process
arginine biosynthetic process
arginine metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
macromolecule metabolic process
metabolic process
protein metabolic process
proteolysis
Gene Properties
Locus tag: PA5206
Strand: -
Entrez Gene ID: 879575
Accession: NP_253893.1
GI: 15600399
Sequence start: 5860467
Sequence End: 5861621
Sequence Length: 1154
Gene Sequence: 
>PA5206
ATGCCGTTGCCGTCTCTGAAAGACCAGTTCGGCGCGCTGATCGCCGCGTCTTCCGTCAGTTGCACCCAGCCCGAGCTGGACCAGACCAACCGCCCGGTGGTCGACCTGCTGGCCTCCTGGCTGGGCGATCTAGGCTTCCGCTGCGAGATCCGGGAAGTCTCGCCGGGCAAGTTCAACCTGCTGGCCAGCTACGGCAGCGGTCCCGGCGGGCTGGTGCTGGCCGGCCACACCGATACCGTGCCCTACGACGAAGCGCTGTGGAGCAGCGATCCGCTGCGCCTGGACGAGCGCGACGGCCGCTGGTACGGCCTCGGCAGTTGCGACATGAAGGGCTTCTTCCCGCTGGCCATCGAGGCCTTGCTGCCGCTGCTCGACCAGCCGTTCCGCCAGCCGCTGATGATCCTCGCCACCTGCGACGAGGAAAGCTCGATGGCCGGCGCCCGTGCCCTCGCCGAAAGCGGGCGACCGCTGGGTCGCGCCACGGTGATCGGCGAGCCGACCAACCTGCGGCCGATCCGCCTGCACAAGGGGGTGATGATGGAGCGCATCGAGATTCTCGGGCAGAGCGGCCATTCGTCCGATCCGAACCTCGGCCGTAGCGCCCTGGAGGCCATGCACGCGACCATCGGCGAGCTGATGGCGCTGCGCGGGGAATGGCAGCGGGCCTGGAACAACCCGCAGTTCAGCGTGCCCCAGCCGACCCTGAACTTCGGTTGCATCCACGGTGGCGACAATCCCAACCGCATCTGCGGCCAGTGTTCGCTGGAATTCGACCTGCGCCCGCTACCCGGCATGCAGCCTAAGCAGTTGCGCGAGGCGATCCGCCAGCGCCTGCGGCCGCTGGCCGAACGGCACCAGGTGAGCATCGACTACCAGCCGCTGTTCCCTGCCGTGCCGCCGTTCGAACAGGCGCAGGACAGCGAACTGGTACGCGTCGCCGAACGCCTGACCGGGCATCGCGCGGAGGCCGTGGCGTTCGGTACCGAGGCGCCGTACTTCCAGCGCCTGGGCAGCGAGACCCTGGTCCTCGGTGCCGGCGACATCGCCTGTGCCCACCAGCCCGACGAGCACCTCGAACTGGCGCGTATCGAACCGATGGTCGGCGTGCTGCGCCGGCTGATCCAGCATTACTGCCTGACGCCCGCCGCCGACTGA
Protein Properties
Protein Residues: 384
Protein Molecular Weight: 42.2 kDa
Protein Theoretical pI: 5.27
Hydropathicity (GRAVY score): -0.216
Charge at pH 7 (predicted): -9.85
Protein Sequence: 
>PA5206
MPLPSLKDQFGALIAASSVSCTQPELDQTNRPVVDLLASWLGDLGFRCEIREVSPGKFNLLASYGSGPGGLVLAGHTDTVPYDEALWSSDPLRLDERDGRWYGLGSCDMKGFFPLAIEALLPLLDQPFRQPLMILATCDEESSMAGARALAESGRPLGRATVIGEPTNLRPIRLHKGVMMERIEILGQSGHSSDPNLGRSALEAMHATIGELMALRGEWQRAWNNPQFSVPQPTLNFGCIHGGDNPNRICGQCSLEFDLRPLPGMQPKQLREAIRQRLRPLAERHQVSIDYQPLFPAVPPFEQAQDSELVRVAERLTGHRAEAVAFGTEAPYFQRLGSETLVLGAGDIACAHQPDEHLELARIEPMVGVLRRLIQHYCLTPAAD
References
External Links:
Resource Link
Genome ID: PA5206
Entrez Gene ID: 879575
NCBI Protein ID: 15600399
General Reference: PaperBLAST - Find papers about PA5206 and its homologs