3'(2'),5'-bisphosphate nucleotidase cysQ (PA5175)

Identification
Name: 3'(2'),5'-bisphosphate nucleotidase cysQ
Synonyms:
  • 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
  • 3'-phosphoadenosine 5'-phosphate phosphatase
  • PAP phosphatase
  • DPNPase
Gene Name: cysQ
Enzyme Class:
Biological Properties
General Function: Involved in magnesium ion binding
Specific Function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2)
Cellular Location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Phosphoadenosine phosphosulfate + Water ↔ Adenosine phosphosulfate + Phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine 3',5'-diphosphate + Water ↔ Adenosine monophosphate + Phosphate
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SMPDB Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Phosphoadenosine phosphosulfate + Water ↔ Phosphate + Adenosine phosphosulfate
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Water + Adenosine 3',5'-diphosphate → Adenosine monophosphate + Phosphate
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Thumb+Thumb → Thumb+Thumb
Adenosine 3',5'-diphosphate + Water → Phosphate + Adenosine monophosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine 3',5'-diphosphate + Water → Adenosine monophosphate + Inorganic phosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000022Adenosine 3',5'-diphosphateMetaboCard
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000222Adenosine phosphosulfateMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000269Phosphoadenosine phosphosulfateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
membrane
Function
binding
catalytic activity
cation binding
hydrolase activity
hydrolase activity, acting on ester bonds
inositol or phosphatidylinositol phosphatase activity
ion binding
magnesium ion binding
metal ion binding
phosphatase activity
phosphoric ester hydrolase activity
Gene Properties
Locus tag: PA5175
Strand: -
Entrez Gene ID: 881784
Accession: NP_253862.1
GI: 15600368
Sequence start: 5828086
Sequence End: 5828907
Sequence Length: 821
Gene Sequence: 
>PA5175
ATGAGGCCGGTGCCTTGGGGCGAATTGGTGGCGCTGGTGCGGCGCGCCGGCGAGGCGATCCTGCCGCACTGGCGCGCCGACGTGGTGGTGCGCTCGAAGGCCGACGAATCGCCGGTGACTGCCGCCGACCTGGCCGCGCACCATATATTGGAGGCGGGATTGCGGGCGCTGGCGCCGGACATTCCGGTGCTTTCCGAAGAGGATTGCGAGATACCGCTGAGCGAGCGCGGCCACTGGCGGCGCTGGTGGCTGGTGGACCCGCTGGACGGCACCAAGGAGTTCATCTCCGGTAGCGAGGAGTTCACCGTCAACGTGGCCCTGGTCGAGGATGGCCGGGTGCTGTTCGGCCTGGTCGGCGTGCCGGTGAGCGGCCGCTGCTACTACGGTGGCGCCGGTCTCGGTGCCTGGCGCGAGGAGGCCGATGGCCGCGCGCAACCGATCAGTGTGCGCCTGGAGCCCGAGGAGGCCTTCACCGTGGTGGCCAGCAAGCGCCATGGCAGCCCGGCCCAGGAGCGCCTGCTGGATGGCTTGAGCGAGCGCTTCGGCGACCTGCGGCGAGCCAGCATCGGCAGTTCGCTGAAGTTCTGCCTGCTGGCCGAGGGCGCTGCCGACTGCTATCCGCGCCTGACGCCAACCTCGCAATGGGACACGGCCGCCGCCCAGGGTGTGCTGGAAGGCGCCGGCGGCGAGGTGCTCGACCTGCATGGTGCGCCATTCACCTACGAGCCGCGCGAGGATTACCTCAACGGCTCCTTCCTGGCCCTGCCGCGCGCCGCCGAGTGGCGCAGCGAGCTGATCCAACTGGCGCGCGCGCTGCACTGA
Protein Properties
Protein Residues: 273
Protein Molecular Weight: 29.8 kDa
Protein Theoretical pI: 4.79
Hydropathicity (GRAVY score): -0.144
Charge at pH 7 (predicted): -11.43
Protein Sequence: 
>PA5175
MRPVPWGELVALVRRAGEAILPHWRADVVVRSKADESPVTAADLAAHHILEAGLRALAPDIPVLSEEDCEIPLSERGHWRRWWLVDPLDGTKEFISGSEEFTVNVALVEDGRVLFGLVGVPVSGRCYYGGAGLGAWREEADGRAQPISVRLEPEEAFTVVASKRHGSPAQERLLDGLSERFGDLRRASIGSSLKFCLLAEGAADCYPRLTPTSQWDTAAAQGVLEGAGGEVLDLHGAPFTYEPREDYLNGSFLALPRAAEWRSELIQLARALH
References
External Links:
Resource Link
Genome ID: PA5175
Entrez Gene ID: 881784
NCBI Protein ID: 15600368
General Reference: PaperBLAST - Find papers about PA5175 and its homologs