Glucose-1-phosphate thymidylyltransferase 1 (PA5163)

Identification
Name: Glucose-1-phosphate thymidylyltransferase 1
Synonyms:
  • G1P-TT 1
  • dTDP-glucose pyrophosphorylase 1
  • dTDP-glucose synthase 1
Gene Name: rmlA1
Enzyme Class:
Biological Properties
General Function: Involved in glucose-1-phosphate thymidylyltransferase activity
Specific Function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Thymidine 5'-triphosphate + Glucose 1-phosphate + Hydrogen ion ↔ dTDP-D-Glucose + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Thymidine 5'-triphosphate + Glucose 1-phosphate ↔ Pyrophosphate + dTDP-D-Glucose
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Pyrophosphate+Thumb
Thymidine 5'-triphosphate + Hydrogen ion + Glucose 1-phosphate → Pyrophosphate + dTDP-D-Glucose
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α-D-glucose 1-phosphate+Thumb+Thumb → Thumb+Thumb
α-D-glucose 1-phosphate + Thymidine 5'-triphosphate + Hydrogen ion → dTDP-D-Glucose + Pyrophosphate
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Thymidine 5'-triphosphate + Glucose 1-phosphate + Hydrogen ion ↔ dTDP-D-Glucose + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Hydrogen ion + Glucose 1-phosphate + Thymidine 5'-triphosphate ↔ dTDP-D-Glucose + Pyrophosphate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000339dTDP-D-GlucoseMetaboCard
PAMDB000423Glucose 1-phosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB001135TDP-GlucoseMetaboCard
PAMDB000346Thymidine 5'-triphosphateMetaboCard
GO Classification:
Function
catalytic activity
glucose-1-phosphate thymidylyltransferase activity
nucleotidyltransferase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
biosynthetic process
carbohydrate metabolic process
cellular polysaccharide biosynthetic process
extracellular polysaccharide biosynthetic process
metabolic process
polysaccharide biosynthetic process
polysaccharide metabolic process
primary metabolic process
Gene Properties
Locus tag: PA5163
Strand: +
Entrez Gene ID: 879990
Accession: NP_253850.1
GI: 15600356
Sequence start: 5812241
Sequence End: 5813122
Sequence Length: 881
Gene Sequence: 
>PA5163
ATGAAACGCAAGGGCATCATCCTCGCCGGAGGCTCGGGCACCCGCCTGCACCCGGCAACGCTGGCCATCTCCAAGCAGTTGCTGCCGGTGTACGACAAGCCGATGATCTACTACCCGCTCAGTACCCTGATGCTGGCGGGCATCCGCGAGATACTGATCATCTCGACCCCACAGGACACCCCACGCTTCCAGCAGTTGCTGGGCGACGGTTCGAACTGGGGCCTGGACCTGCAATATGCCGTGCAACCGTCGCCGGACGGCCTGGCCCAGGCCTTCCTGATCGGCGAGTCGTTCATCGGCAACGACCTCAGCGCGCTGGTCCTGGGCGACAACCTCTATTACGGCCACGACTTCCACGAGTTGCTCGGCAGCGCTTCGCAGCGCCAGACCGGCGCCAGTGTCTTCGCCTACCACGTGCTGGACCCGGAGCGCTACGGCGTGGTCGAGTTCGACCAGGGCGGCAAGGCCATCAGCCTGGAAGAGAAGCCACTGGAGCCGAAGTCGAACTACGCGGTCACCGGCCTGTATTTCTACGACCAGCAGGTGGTGGACATCGCCAGGGACCTGAAGCCTTCGCCGCGCGGCGAGCTGGAGATCACCGACGTCAACCGCGCCTATCTGGAGCGCGGCCAGCTCAGCGTGGAGATCATGGGCCGCGGCTACGCCTGGCTGGATACCGGCACCCACGATTCGCTGCTCGAGGCCGGCCAGTTCATCGCCACCCTGGAGAACCGCCAGGGTCTCAAGGTGGCCTGCCCGGAAGAGATCGCCTACCGGCAGAAGTGGATCGACGCCGCGCAACTGGAAAAACTCGCCGCGCCGCTGGCCAAGAACGGCTACGGCCAATACCTCAAGCGCCTGCTGACCGAGACCGTGTACTGA
Protein Properties
Protein Residues: 293
Protein Molecular Weight: 32.5 kDa
Protein Theoretical pI: 5.02
Hydropathicity (GRAVY score): -0.194
Charge at pH 7 (predicted): -6.83
Protein Sequence: 
>PA5163
MKRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFQQLLGDGSNWGLDLQYAVQPSPDGLAQAFLIGESFIGNDLSALVLGDNLYYGHDFHELLGSASQRQTGASVFAYHVLDPERYGVVEFDQGGKAISLEEKPLEPKSNYAVTGLYFYDQQVVDIARDLKPSPRGELEITDVNRAYLERGQLSVEIMGRGYAWLDTGTHDSLLEAGQFIATLENRQGLKVACPEEIAYRQKWIDAAQLEKLAAPLAKNGYGQYLKRLLTETVY
References
External Links:
Resource Link
Genome ID: PA5163
Entrez Gene ID: 879990
NCBI Protein ID: 15600356
General Reference: PaperBLAST - Find papers about PA5163 and its homologs