1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (PA5141)

Identification
Name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Synonyms:
  • Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene Name: hisA
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5- ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5- phosphoribosyl)imidazole-4-carboxamide
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb
PhosphoribosylformiminoAICAR-phosphate ↔ Phosphoribulosylformimino-AICAR-P
ReactionCard
SMPDB Reactions:
Thumb → Thumb
AICAR → PhosphoribosylformiminoAICAR-phosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb
PhosphoribosylformiminoAICAR-phosphate ↔ Phosphoribulosylformimino-AICAR-P
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0035851-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideMetaboCard
PAMDB000407AICARMetaboCard
PAMDB000837PhosphoribosylformiminoAICAR-phosphateMetaboCard
PAMDB000838Phosphoribulosylformimino-AICAR-PMetaboCard
GO Classification:
Function
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
catalytic activity
intramolecular oxidoreductase activity
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
isomerase activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
histidine biosynthetic process
histidine family amino acid metabolic process
histidine metabolic process
metabolic process
Gene Properties
Locus tag: PA5141
Strand: -
Entrez Gene ID: 878542
Accession: NP_253828.1
GI: 15600334
Sequence start: 5789395
Sequence End: 5790132
Sequence Length: 737
Gene Sequence: 
>PA5141
ATGCTGATCATTCCCGCGATCGACTTGAAAGACGGCGCCTGCGTGCGTCTGCGCCAGGGCCTGATGGAAGACGCCACGGTCTTCTCCGACGATCCGGTGGCGATGGCCGCCAAATGGGTCGATGGCGGTTGCCGCCGCCTGCACCTGGTGGACCTGAACGGCGCTTTCGAAGGCAAGCCGGTCAACGGCGAGGTGGTCACCGCCATCGCCCGTCGCTACCCGGACCTGCCGATCCAGATCGGCGGCGGCATCCGCTCGCTGGAAACCATCGAGCATTACGTTCGCGCCGGCGTCAGCTACGTCATCATCGGCACCAAGGCGGTCAAGCAGCCTGAGTTCGTCGGCGAGGCCTGCCGCGCCTTCCCGGGCAAGGTCATCGTCGGCCTGGATGCCAAGGACGGTTTCGTCGCCACCGACGGCTGGGCCGAGGTCAGCGAAGTCCAGGTGATCGACCTGGCTCGTCGCTTCGAGGCCGACGGGGTGTCCGCCATCGTCTACACGGATATTTCCAAGGACGGCATGATGCAGGGCTGCAACGTCGAGGCTACCGCCGCGCTGGCCAATGCCACGCGGATCCCGGTGATCGCCTCCGGCGGCATCCACAATCTCGGCGACATCCAGAAGCTGCTGGACGCCCGCACCCCGGGGATCATCGGCGCCATCACCGGCCGGGCGATCTACGAAGGCACCCTGGACGTGGCCGAAGCCCAGGCGCTGTGCGACAACTTCAAGGCCTGA
Protein Properties
Protein Residues: 245
Protein Molecular Weight: 25.9 kDa
Protein Theoretical pI: 4.72
Hydropathicity (GRAVY score): 0.195
Charge at pH 7 (predicted): -7.43
Protein Sequence: 
>PA5141
MLIIPAIDLKDGACVRLRQGLMEDATVFSDDPVAMAAKWVDGGCRRLHLVDLNGAFEGKPVNGEVVTAIARRYPDLPIQIGGGIRSLETIEHYVRAGVSYVIIGTKAVKQPEFVGEACRAFPGKVIVGLDAKDGFVATDGWAEVSEVQVIDLARRFEADGVSAIVYTDISKDGMMQGCNVEATAALANATRIPVIASGGIHNLGDIQKLLDARTPGIIGAITGRAIYEGTLDVAEAQALCDNFKA
References
External Links:
Resource Link
Genome ID: PA5141
Entrez Gene ID: 878542
NCBI Protein ID: 15600334
General Reference: PaperBLAST - Find papers about PA5141 and its homologs