Nicotinate phosphoribosyltransferase (PA4919)

Identification
Name: Nicotinate phosphoribosyltransferase
Synonyms:
  • NAPRTase
Gene Name: pncB
Enzyme Class:
Biological Properties
General Function: Involved in nicotinate phosphoribosyltransferase activity
Specific Function: Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate
Cellular Location: Cytoplasm
KEGG Pathways:
  • Nicotinate and nicotinamide metabolism pae00760
KEGG Reactions:
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Nicotinamide ribotide + Pyrophosphate + Adenosine triphosphate + Water ↔ Nicotinic acid + Phosphoribosyl pyrophosphate + ADP + Phosphate
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Thumb+Thumb ← Thumb+Thumb+Thumb
Nicotinamide ribotide + Pyrophosphate ← Hydrogen ion + Nicotinic acid + Phosphoribosyl pyrophosphate
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Thumb+Thumb → Thumb+Thumb
Nicotinamide ribotide + Pyrophosphate → Nicotinic acid + Phosphoribosyl pyrophosphate
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SMPDB Reactions:
Thumb+Thumb+Thumb+Thumb → Thumb+Adenosine diphosphate+Pyrophosphate+nicotinate beta-D-ribonucleotide+Thumb+Thumb
Nicotinic acid + Water + Adenosine triphosphate + Phosphoribosyl pyrophosphate → Phosphate + Adenosine diphosphate + Pyrophosphate + nicotinate beta-D-ribonucleotide + ADP + Nicotinamide ribotide
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ← Thumb+Thumb+Thumb
Nicotinamide ribotide + Pyrophosphate ← Hydrogen ion + Nicotinic acid + Phosphoribosyl pyrophosphate
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Thumb+Thumb → Thumb+Thumb
Nicotinamide ribotide + Pyrophosphate → Nicotinic acid + Phosphoribosyl pyrophosphate
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Complex Reactions:
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Water + Nicotinic acid + Phosphoribosyl pyrophosphate → ADP + Nicotinamide ribotide + Phosphate + Pyrophosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000095Nicotinamide ribotideMetaboCard
PAMDB000399Nicotinic acidMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
catalytic activity
nicotinate phosphoribosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
Process
cellular metabolic process
cellular nitrogen compound metabolic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
nicotinate nucleotide biosynthetic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide biosynthetic process
nucleotide metabolic process
pyridine nucleotide biosynthetic process
Gene Properties
Locus tag: PA4919
Strand: +
Entrez Gene ID: 882212
Accession: NP_253606.1
GI: 15600112
Sequence start: 5518483
Sequence End: 5519682
Sequence Length: 1199
Gene Sequence: 
>PA4919
ATGGCCGAAAGCGTCTTTGCCGAGCGCATTGTGCAGAACCTGCTCGATACCGATTTCTACAAGCTGACCATGATGCAGGCGGTGCTGCACAACTACCCCAACGCCGAAGTGGAGTGGGAATTCCGCTGCCGCAACGCCGAGGACCTGCGTCCGTACCTGGCGGAGATCCGCTACCAGATCGAGCGCCTCGCCGAAGTCGAGGTAACCGCCGACCAGCTCGCCTTCCTCGAACGCATCCCGTTCATGAAGCCGGACTTCATCCGCTTCCTCAGCCTGTTCCGCTTCAACCTGCGCTACGTGCACACCGGCATCGAGGATGGCCAACTGGCAATCCGCCTGCGCGGCCCATGGCTGCACGTGATCCTCTTCGAGGTGCCGCTGCTGGCCATCGTCAGCGAGGTGCGCAACCGTTATCGCTACCGCGAGGTGGTCCTGGAACAGGTCGGCGAGCAGCTCTATCGCAAGCTCGACTGGCTCTCCGCCCAGGCCAGCAGCGAGGAACTCGCGGAATTCCAGGTCGCCGACTTCGGCACCCGCCGGCGCTTCTCCTACCGCACCCAGGAGGAAGTGGTGCATATCCTCAAGCGCGACTTCCCCGGGCGCTTCGTCGGCACCAGCAACGTGCACCTGGCCCGCGAGTACGACCTCAAGCCGATCGGCACCATGGCCCACGAATGGCTGATGGCCCACCAGCAACTCGGCCCGCGGCTGGTCGACAGCCAGCAAGCGGCGCTGGACTGCTGGGTCCGCGAGTACCGCGGACAGCTCGGCATAGCCCTGACCGACTGCATTACCATGGATGCCTTCCTCGACGACTTCGACCTGTACTTCGCCAAGCTCTTCGACGGCCTGCGCCACGATTCGGGCGACCCGCTGGCCTGGGCGGAGAAAGCCATCGCCCACTACCGCCGCCTGGGTATCGACCCGCTGAGCAAGACCCTGGTGTTCTCCGACGGGCTGGACATGCCCAAGGCGTTGCAGCTGTTCCGCGCGCTACGTGGCAAGATCAACGTCAGCTTCGGCATCGGCACCAACCTGACCTGCGACATCCCGGGGGTCGAGCCGATGAACATCGTCCTGAAGATGACGGCCTGCAACGGCCATCCGGTGGCGAAGATATCCGACGCCCCGGGCAAGACCCAATGCCGCGACGAGAACTTCGTCGCCTACCTCCGCCACGTCTTCAACGTGCCGGCCTAA
Protein Properties
Protein Residues: 399
Protein Molecular Weight: 46.1 kDa
Protein Theoretical pI: 6.3
Hydropathicity (GRAVY score): -0.153
Charge at pH 7 (predicted): -4.52
Protein Sequence: 
>PA4919
MAESVFAERIVQNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRNAEDLRPYLAEIRYQIERLAEVEVTADQLAFLERIPFMKPDFIRFLSLFRFNLRYVHTGIEDGQLAIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVVLEQVGEQLYRKLDWLSAQASSEELAEFQVADFGTRRRFSYRTQEEVVHILKRDFPGRFVGTSNVHLAREYDLKPIGTMAHEWLMAHQQLGPRLVDSQQAALDCWVREYRGQLGIALTDCITMDAFLDDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYRRLGIDPLSKTLVFSDGLDMPKALQLFRALRGKINVSFGIGTNLTCDIPGVEPMNIVLKMTACNGHPVAKISDAPGKTQCRDENFVAYLRHVFNVPA
References
External Links:
Resource Link
Genome ID: PA4919
Entrez Gene ID: 882212
NCBI Protein ID: 15600112
General Reference: PaperBLAST - Find papers about PA4919 and its homologs