P. aeruginosa Metabolome Database Protein PA4759

Identification

Name:

Dihydrodipicolinate reductase

Synonyms:

DHPR

Gene Name:

dapB

Enzyme Class:

Biological Properties

General Function:

Involved in dihydrodipicolinate reductase activity

Specific Function:

2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H

Cellular Location:

Cytoplasm

KEGG Pathways:

Lysine biosynthesis pae00300
Monobactam biosynthesis pae00261

KEGG Reactions:

→

2,3-Dihydrodipicolinic acid + Hydrogen ion + NADPH → NADP + Tetrahydrodipicolinate
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↔

Tetrahydrodipicolinate + NAD ↔ 2,3-Dihydrodipicolinic acid + NADH + Hydrogen ion
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↔

Tetrahydrodipicolinate + NADP ↔ 2,3-Dihydrodipicolinic acid + NADPH + Hydrogen ion
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↔

Tetrahydrodipicolinate + NAD + NADP + Water ↔ (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + NADPH + Hydrogen ion
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SMPDB Reactions:

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate

NADPH

→

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen ion + NADPH + (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH → Water + NADP + (S)-2,3,4,5-tetrahydrodipicolinate
ReactionCard

PseudoCyc/BioCyc Reactions:

→

2,3-Dihydrodipicolinic acid + Hydrogen ion + NADPH → NADP + Tetrahydrodipicolinate
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↔

Tetrahydrodipicolinate + NAD ↔ 2,3-Dihydrodipicolinic acid + NADH + Hydrogen ion
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↔

Tetrahydrodipicolinate + NADP ↔ 2,3-Dihydrodipicolinic acid + NADPH + Hydrogen ion
ReactionCard

↔

Tetrahydrodipicolinate + NAD + NADP + Water ↔ (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + NADPH + Hydrogen ion
ReactionCard

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate

NADPH

→

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen ion + NADPH + (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH → Water + NADP + (S)-2,3,4,5-tetrahydrodipicolinate
ReactionCard

(S)-2,3-dihydrodipicolinate + NADPH + H⁺ = (S)-2,3,4,5-tetrahydrodipicolinate + NADP⁺
ReactionCard

Complex Reactions:

Not Available

Transports:

Not Available

Metabolites:

PAMDB ID	Name	View
PAMDB004261	(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate	MetaboCard
PAMDB006304	(S)-2,3,4,5-tetrahydrodipicolinate	MetaboCard
PAMDB000588	2,3-Dihydrodipicolinic acid	MetaboCard
PAMDB001633	Hydrogen ion	MetaboCard
PAMDB000197	NAD	MetaboCard
PAMDB000398	NADH	MetaboCard
PAMDB000089	NADP	MetaboCard
PAMDB000615	NADPH	MetaboCard
PAMDB000840	Tetrahydrodipicolinate	MetaboCard
PAMDB000142	Water	MetaboCard

GO Classification:

Component
cell part
cytoplasm
intracellular part
Function
binding
catalytic activity
dihydrodipicolinate reductase activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Process
aspartate family amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
lysine biosynthetic process
lysine biosynthetic process via diaminopimelate
lysine metabolic process
metabolic process
oxidation reduction

Gene Properties

Locus tag:

PA4759

Strand:

Entrez Gene ID:

881759

Accession:

NP_253447.1

GI:

15599953

Sequence start:

5345086

Sequence End:

5345892

Sequence Length:

806

Gene Sequence:

>PA4759
ATGCGACGTATAGCCGTAGTGGGCGCCGCCGGGCGCATGGGCAAGAACCTGATCGAGGCCGTTCAGCAGACCGGCGGTGCCGCCGGGCTGACGGCGGCGGTGGATCGTCCGGATAGCACCCTGGTGGGGGCGGACGCCGGCGAGCTGGCCGGTCTCGGCCGGATCGGCGTGCCGCTGTCCGGGGACCTGGGCAAGGTCTGCGAGGAGTTCGACGTCCTGATCGACTTCACCCATCCCTCCGTAACCCTGAAGAACATCGAGCAGTGCCGCAAGGCGCGCCGGGCGATGGTCATCGGCACCACCGGCTTCAGCGCCGACGAGAAGCTGCTGCTGGCCGAGGCGGCGAAGGATATCCCGATCGTCTTCGCTGCCAACTTCAGCGTCGGCGTGAACCTTTGCCTGAAGCTTCTGGATACCGCGGCACGGGTGTTGGGCGACGAAGTGGATATCGAGATCATCGAGGCCCATCACCGGCACAAGGTCGATGCACCGTCCGGCACCGCCTTGCGCATGGGCGAGGTGGTAGCCCAGGCGCTCGGCCGGGACCTCCAGGAAGTGGCGGTCTACGGACGCGAGGGGCAGACCGGCGCGCGGGCGCGGGAAACCATCGGCTTCGCCACCGTGCGCGCCGGCGACGTGGTGGGCGACCACACCGTGCTGTTCGCCGCCGAGGGCGAGCGCGTGGAGATCACCCACAAGGCTTCCAGCCGCATGACCTTCGCCCGTGGCGCGGTGCGTGCGGCGCTGTGGCTGGAGGGCAAGGAGAACGGCCTGTACGACATGCAGGATGTGCTCGGCCTACGCTGA

Protein Properties

Protein Residues:

268

Protein Molecular Weight:

28.3 kDa

Protein Theoretical pI:

5.98

Hydropathicity (GRAVY score):

0.071

Charge at pH 7 (predicted):

-3.64

Protein Sequence:

>PA4759
MRRIAVVGAAGRMGKNLIEAVQQTGGAAGLTAAVDRPDSTLVGADAGELAGLGRIGVPLSGDLGKVCEEFDVLIDFTHPSVTLKNIEQCRKARRAMVIGTTGFSADEKLLLAEAAKDIPIVFAANFSVGVNLCLKLLDTAARVLGDEVDIEIIEAHHRHKVDAPSGTALRMGEVVAQALGRDLQEVAVYGREGQTGARARETIGFATVRAGDVVGDHTVLFAAEGERVEITHKASSRMTFARGAVRAALWLEGKENGLYDMQDVLGLR

References

External Links:

Resource	Link
Genome ID:	PA4759
Entrez Gene ID:	881759
NCBI Protein ID:	15599953

General Reference:

PaperBLAST - Find papers about PA4759 and its homologs

Dihydrodipicolinate reductase (PA4759)