Dihydropteroate synthase (PA4750)

Identification
Name: Dihydropteroate synthase
Synonyms:
  • DHPS
  • Dihydropteroate pyrophosphorylase
Gene Name: folP
Enzyme Class:
Biological Properties
General Function: Involved in dihydropteroate synthase activity
Specific Function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
6-Hydroxymethyl dihydropterin + p-Aminobenzoic acid ↔ 7,8-Dihydropteroic acid + Water
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Pyrophosphate+Thumb
6-Hydroxymethyl-dihydropterin pyrophosphate + p-Aminobenzoic acid → Pyrophosphate + 7,8-Dihydropteroic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
p-Aminobenzoic acid + 6-Hydroxymethyl-dihydropterin pyrophosphate → 7,8-Dihydropteroic acid + Pyrophosphate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015906-Hydroxymethyl dihydropterinMetaboCard
PAMDB0015916-Hydroxymethyl-dihydropterin pyrophosphateMetaboCard
PAMDB0003767,8-Dihydropteroic acidMetaboCard
PAMDB000367p-Aminobenzoic acidMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
dihydropteroate synthase activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
cellular aromatic compound metabolic process
cellular metabolic process
folic acid and derivative biosynthetic process
folic acid and derivative metabolic process
metabolic process
pteridine and derivative metabolic process
Gene Properties
Locus tag: PA4750
Strand: -
Entrez Gene ID: 881715
Accession: NP_253438.1
GI: 15599944
Sequence start: 5334921
Sequence End: 5335772
Sequence Length: 851
Gene Sequence: 
>PA4750
ATGAGCAATCCGCAATACCCGACCCGACTGCCTTGCGGCAGTCGGGTTCTTGATTTGGCCCGCCCACATGTCATGGGCATCCTCAATGTCACCCCCGATTCCTTTTCCGACGGCGGCCGTTACGACCGGCTGGACGATGCCCTGCGGCATGCCGAGCGCATGGTGCTGGAAGGCGCAACGCTCATCGACGTCGGCGGCGAGTCGACCCGTCCCGGTGCGCGCAGCGTTTCTCCGACGGAGGAGCTGGAGCGGGTCGCTCCGGTAGTCGAACGCATCGCCCGCGAACTGGACGTCGTGATTTCGGTGGATACCTCCACGCCTGCGGTCATGCGCGAAACTGCGCGTCTCGGAGCGGGTCTGATCAACGACGTCCGTTCGCTGCAGCGCGACGGTGCGTTGGATGCTGCGGTGGATAGCGGCCTGGCGGTCTGCCTCATGCACATGCGTGGAGAACCGCAGACCATGCAGGATGCGCCTGCCTACCAGGATGTGGTGGCGGAAGTCGGCGCGTTCCTGCAGGAGCGTGTGGATGCCTGCGTGGCGGCCGGAATCGACCGCGAGCGGCTGTTGCTGGATCCGGGTTTCGGTTTTGCCAAGACACTGGAGCACAACCTGGTGCTGTTCAGGCATCTGCAGGCGCTCCATGGTCTGGGCCTGCCGTTGTTGGTCGGCGTTTCGCGCAAGAGCATGATCGGCAAGGTACTGGGGCGGGAGGTGGACGAACGCCTCTACGGCAGTCTCGCGCTGGCGGCCCTGGCGCTGGCCAAGGGCGCACGGATAATTCGAGTGCATGACGTGGCGGCGACCGTCGACGTGATGCGAATGATCTCCGCCGTTGAAATGGCGGATTGA
Protein Properties
Protein Residues: 283
Protein Molecular Weight: 30.5 kDa
Protein Theoretical pI: 5.4
Hydropathicity (GRAVY score): 0.071
Charge at pH 7 (predicted): -6.4
Protein Sequence: 
>PA4750
MSNPQYPTRLPCGSRVLDLARPHVMGILNVTPDSFSDGGRYDRLDDALRHAERMVLEGATLIDVGGESTRPGARSVSPTEELERVAPVVERIARELDVVISVDTSTPAVMRETARLGAGLINDVRSLQRDGALDAAVDSGLAVCLMHMRGEPQTMQDAPAYQDVVAEVGAFLQERVDACVAAGIDRERLLLDPGFGFAKTLEHNLVLFRHLQALHGLGLPLLVGVSRKSMIGKVLGREVDERLYGSLALAALALAKGARIIRVHDVAATVDVMRMISAVEMAD
References
External Links:
Resource Link
Genome ID: PA4750
Entrez Gene ID: 881715
NCBI Protein ID: 15599944
General Reference: PaperBLAST - Find papers about PA4750 and its homologs