2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (PA4728)

Identification
Name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Synonyms:
  • 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
  • PPPK
  • 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
  • HPPK
Gene Name: folK
Enzyme Class:
Biological Properties
General Function: Involved in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
Specific Function: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6- yl)methyl diphosphate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
6-Hydroxymethyl dihydropterin + Adenosine triphosphate → Adenosine monophosphate + Hydrogen ion + 6-Hydroxymethyl-dihydropterin pyrophosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
6-Hydroxymethyl dihydropterin + Adenosine triphosphate → 6-Hydroxymethyl-dihydropterin pyrophosphate + Adenosine monophosphate + Hydrogen ion
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
6-Hydroxymethyl dihydropterin + Adenosine triphosphate → Hydrogen ion + 6-Hydroxymethyl-dihydropterin pyrophosphate + Adenosine monophosphate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015906-Hydroxymethyl dihydropterinMetaboCard
PAMDB0015916-Hydroxymethyl-dihydropterin pyrophosphateMetaboCard
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
GO Classification:
Function
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
catalytic activity
diphosphotransferase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular aromatic compound metabolic process
cellular metabolic process
folic acid and derivative biosynthetic process
folic acid and derivative metabolic process
metabolic process
Gene Properties
Locus tag: PA4728
Strand: +
Entrez Gene ID: 881616
Accession: NP_253416.1
GI: 15599922
Sequence start: 5310726
Sequence End: 5311214
Sequence Length: 488
Gene Sequence: 
>PA4728
ATGATCCAGCGCGTCTACGTGGCGCTGGGCAGCAACCTGGCCGAACCGCGCGAGCAGATCCAGGCTGCCCTCGATGCCTTCGAGCGGCTTCCCGAGACCCGCCTGGTCGCCGTCTCGCCGCTCTACATCAGCGACCCGCTCGGCCCCGCCGACCAGCCGCGCTTCGTCAACGGCGTGGCGGCCCTCGACACCAACCTGGCGCCGCTCGACCTGCTCGACGCCCTGCAGGCCATCGAACTGGAACAGGGGCGCGTCCGCGACCTGCGCTGGGGTCCGCGCACGCTCGACCTGGACATCCTGCTGTTCGGCGAACAATTGCTCGACCTGCCGCGCCTGAAGGTGCCGCACTACCACATGCAGGCGCGCGCTTTCGTGCTCTATCCCCTCGCCGATCTCGCCCCCGACCTGCGCCTGCCCGATGGCCGCCACCTGCCGGAGCTGCTCGCGGCCTGTCCGTTCGAGGGCATCGAACGCCTTCCGGGCGCCTGA
Protein Properties
Protein Residues: 162
Protein Molecular Weight: 18 kDa
Protein Theoretical pI: 4.56
Hydropathicity (GRAVY score): 0.035
Charge at pH 7 (predicted): -7.31
Protein Sequence: 
>PA4728
MIQRVYVALGSNLAEPREQIQAALDAFERLPETRLVAVSPLYISDPLGPADQPRFVNGVAALDTNLAPLDLLDALQAIELEQGRVRDLRWGPRTLDLDILLFGEQLLDLPRLKVPHYHMQARAFVLYPLADLAPDLRLPDGRHLPELLAACPFEGIERLPGA
References
External Links:
Resource Link
Genome ID: PA4728
Entrez Gene ID: 881616
NCBI Protein ID: 15599922
General Reference: PaperBLAST - Find papers about PA4728 and its homologs