4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (PA4669)

Identification
Name: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Synonyms:
  • CMK
  • 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene Name: ispE
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Phosphorylates isopentenyl phosphate at low rates. Also acts on isopentenol, and, much less efficiently, dimethylallyl alcohol. Dimethylallyl monophosphate does not serve as a substrate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate ↔ 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate ↔ 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP
ReactionCard
SMPDB Reactions:
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol+Thumb+Thumb → Adenosine diphosphate+Thumb+2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol+Thumb+Thumb
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate + 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol → Adenosine diphosphate + Hydrogen ion + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP + 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate ↔ 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate ↔ 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol → ADP + 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0008982-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritolMetaboCard
PAMDB0009314-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritolMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
GO Classification:
Function
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
kinase activity
nucleoside binding
purine nucleoside binding
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular lipid metabolic process
cellular metabolic process
isoprenoid metabolic process
lipid metabolic process
metabolic process
phosphate metabolic process
phosphorus metabolic process
phosphorylation
primary metabolic process
terpenoid biosynthetic process
terpenoid metabolic process
Gene Properties
Locus tag: PA4669
Strand: +
Entrez Gene ID: 881380
Accession: NP_253358.1
GI: 15599864
Sequence start: 5237393
Sequence End: 5238241
Sequence Length: 848
Gene Sequence: 
>PA4669
ATGAGCGTGCGCCTCAGCCTGCCAGCCCCGGCCAAGCTCAATCTGTTCCTGCATATCCTCGGCCGCCGCGACGATGGCTATCACGAGTTGCAGACCCTGTTCCAATTCCTCGACCACGGCGACGAGCTGCATTTCGAAGCCCGCCAGGACGGCCAGGTACGCCTGCACACGGAAATCGCCGGGGTGCCGCACGACAGCAACCTGATCGTGCGCGCCGCGCGCGGGCTGCAGGAAGCCTCCGGCAGCCCGCAAGGCGTCGACATCTGGCTGGACAAGCGCTTGCCCATGGGGGGCGGCATCGGCGGCGGCAGCTCCGACGCCGCCACGACGCTCCTGGCCTTGAACCATCTCTGGCAACTCGGCTGGGACGAGGACCGCATCGCCGCCCTGGGCCTGCGCCTGGGCGCCGACGTGCCGGTCTTCACCCGCGGACGCGCAGCTTTCGCCGAGGGCGTGGGCGAAAAGCTCACCCCGGTGGACATCCCGGAGCCCTGGTATCTCGTCGTGGTTCCGCAAGTACTTGTCAGCACAGCAGAAATTTTTTCAGATCCACTGTTGACACGCGATTCTCCCGCCATTAAAGTGCGCACCGTTCTCGAGGGGGACAGCCGAAACGACTGTCAGCCGGTAGTCGAGAGGCGTTACCCAGAAGTTCGTAACGCTTTGATCTTGCTAAACAAATTTGTTTCAGCTAGATTAACCGGCACTGGAGGTTGTGTGTTTGGGAGCTTCCCAAACAAAGCTGAAGCTGATAAAGTCTCGGCCCTTCTTCCAGACCACCTTCAGAGGTTCGTCGCCAAAGGAAGCAACATCTCGATGTTGCACCGGAAGCTGGAAACTCTGGTCTGA
Protein Properties
Protein Residues: 282
Protein Molecular Weight: 30.8 kDa
Protein Theoretical pI: 6.61
Hydropathicity (GRAVY score): -0.078
Charge at pH 7 (predicted): -1.89
Protein Sequence: 
>PA4669
MSVRLSLPAPAKLNLFLHILGRRDDGYHELQTLFQFLDHGDELHFEARQDGQVRLHTEIAGVPHDSNLIVRAARGLQEASGSPQGVDIWLDKRLPMGGGIGGGSSDAATTLLALNHLWQLGWDEDRIAALGLRLGADVPVFTRGRAAFAEGVGEKLTPVDIPEPWYLVVVPQVLVSTAEIFSDPLLTRDSPAIKVRTVLEGDSRNDCQPVVERRYPEVRNALILLNKFVSARLTGTGGCVFGSFPNKAEADKVSALLPDHLQRFVAKGSNISMLHRKLETLV
References
External Links:
Resource Link
Genome ID: PA4669
Entrez Gene ID: 881380
NCBI Protein ID: 15599864
General Reference: PaperBLAST - Find papers about PA4669 and its homologs