Ferrochelatase (PA4655)

Identification
Name: Ferrochelatase
Synonyms:
  • Heme synthase
  • Protoheme ferro-lyase
Gene Name: hemH
Enzyme Class:
Biological Properties
General Function: Involved in ferrochelatase activity
Specific Function: Catalyzes the ferrous insertion into protoporphyrin IX
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Fe2+ ↔ Thumb+2 Thumb+Thumb
Protoporphyrin IX + Fe2+ ↔ Heme + 2 Hydrogen ion + Fe2+
ReactionCard
SMPDB Reactions:
Thumb+Thumb → 2 Thumb+Thumb
Protoporphyrin IX + Iron → 2 Hydrogen ion + ferroheme b
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → 2 Thumb+Thumb
Iron + Protoporphyrin IX → 2 Hydrogen ion + Heme
ReactionCard
Thumb+Thumb → Thumb+Thumb
Iron + Protoporphyrin IX → Heme + Hydrogen ion
ReactionCard
Complex Reactions:
Thumb+2 Thumb → Thumb+Thumb
Heme + 2 Hydrogen ion → Protoporphyrin IX + Iron
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB005697Fe2+MetaboCard
PAMDB006369ferroheme bMetaboCard
PAMDB000481HemeMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000172IronMetaboCard
PAMDB000101Protoporphyrin IXMetaboCard
GO Classification:
Function
catalytic activity
ferrochelatase activity
lyase activity
Process
heme biosynthetic process
metabolic process
nitrogen compound metabolic process
porphyrin biosynthetic process
porphyrin metabolic process
tetrapyrrole metabolic process
Gene Properties
Locus tag: PA4655
Strand: -
Entrez Gene ID: 881311
Accession: NP_253344.1
GI: 15599850
Sequence start: 5222540
Sequence End: 5223562
Sequence Length: 1022
Gene Sequence: 
>PA4655
ATGACCGAGAATGCCCTGCTGTTGCTCAACCTGGGCTCCCCGGATTCGACCCGGGTGGAGGATGTCCGCCGCTATCTCGACCAGTTCCTCATGGATCCCTACGTGGTCGACCTGCCCTGGCCGCTGCGGCGCCTGCTGGTGTCGCTGATCCTGATCAAGCGTCCGGCCGAATCGGCGCACGCCTACAGCTCGATCTGGTGGGACGAAGGGTCGCCACTGATCGTCCTCAGTCGTCGCCTGCAGGAGGCGATGAAGCCGCACTGGCCGCATGGGCCGGTGGAACTGGCGATGCGCTACGGCCAGCCGGCCATCGAGAAGGTCCTGCTCGACCTGGCGCGCCGCGGTATCCGGCGGGTGACCCTGGCGCCGCTGTATCCGCAGTTCGCCGACAGCACCACGACCACCGCCGAACAGGAGGTGCGCCGGGTGATCGCCGCCCATCGCCTGGGCCTGGAGGTCAGCACGCTGCCGCCGTTCTACGACCAGCCGGTCTACCTCGATGCCCTGGTGGAAAGCGTGCGTCCGTACCTGCAGCAGCCCCACGACCATCTGTTGCTGAGCTTCCATGGCTTGCCCGAGCGGCACATCCGCAAGCTGGTGAAGGATCCTGCCCACGACCTGCTGGCCGAGAACAGCCGCAACGTCAGCCCCGAAGCCCTCGCCCTCTGCTACCGCAGCCAGTGCCTGCGCACCGCCGAGGCCTTCGCCGAGCGCGCCGGCCTGGAGCAGGGGCGCTGGTCGGTGTCGTTCCAGTCGCGCCTGGGGCGCGCCAAGTGGATCGAGCCCTATACCGACGCCAAGCTCGACGAACTGGTGCAGCGCGGGGTGAAGCGCCTGCTGGTGATGTGTCCGGCGTTCGTTGCCGACTGCATCGAGACCCTGGAGGAAATCGGCATGCGCGGCCGCGAGCAGTTCATCAGTGCCGGCGGCGAGGACCTGGTGCTGATTCCCTGCCTCAACGACCACCCCGCCTGGGTCGGCGCCCTGGCCGAGATGAGCGGGCGCTTGGCCAGGCCGCTCTGA
Protein Properties
Protein Residues: 340
Protein Molecular Weight: 38.6 kDa
Protein Theoretical pI: 6.85
Hydropathicity (GRAVY score): -0.157
Charge at pH 7 (predicted): -0.74
Protein Sequence: 
>PA4655
MTENALLLLNLGSPDSTRVEDVRRYLDQFLMDPYVVDLPWPLRRLLVSLILIKRPAESAHAYSSIWWDEGSPLIVLSRRLQEAMKPHWPHGPVELAMRYGQPAIEKVLLDLARRGIRRVTLAPLYPQFADSTTTTAEQEVRRVIAAHRLGLEVSTLPPFYDQPVYLDALVESVRPYLQQPHDHLLLSFHGLPERHIRKLVKDPAHDLLAENSRNVSPEALALCYRSQCLRTAEAFAERAGLEQGRWSVSFQSRLGRAKWIEPYTDAKLDELVQRGVKRLLVMCPAFVADCIETLEEIGMRGREQFISAGGEDLVLIPCLNDHPAWVGALAEMSGRLARPL
References
External Links:
Resource Link
Genome ID: PA4655
Entrez Gene ID: 881311
NCBI Protein ID: 15599850
General Reference: PaperBLAST - Find papers about PA4655 and its homologs