ATP phosphoribosyltransferase (PA4449)

Identification
Name: ATP phosphoribosyltransferase
Synonyms:
  • ATP-PRT
  • ATP-PRTase
Gene Name: hisG
Enzyme Class:
Biological Properties
General Function: Involved in ATP phosphoribosyltransferase activity
Specific Function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Phosphoribosyl pyrophosphate ↔ Pyrophosphate + Phosphoribosyl-ATP
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Thumb+Thumb ↔ Thumb+Thumb
Phosphoribosyl-ATP + Pyrophosphate ↔ Adenosine triphosphate + Phosphoribosyl pyrophosphate
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SMPDB Reactions:
Thumb+Thumb → Pyrophosphate+Phosphoribosyl-ATP+Thumb
Phosphoribosyl pyrophosphate + Hydrogen ion → Pyrophosphate + Phosphoribosyl-ATP + Phosphoribosyl-ATP
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Phosphoribosyl pyrophosphate ↔ Pyrophosphate + Phosphoribosyl-ATP
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Phosphoribosyl-ATP + Pyrophosphate → Adenosine triphosphate + Phosphoribosyl pyrophosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
PAMDB000631Phosphoribosyl-ATPMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
ATP phosphoribosyltransferase activity
binding
catalytic activity
cation binding
ion binding
magnesium ion binding
metal ion binding
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
histidine biosynthetic process
histidine family amino acid metabolic process
histidine metabolic process
metabolic process
Gene Properties
Locus tag: PA4449
Strand: -
Entrez Gene ID: 880968
Accession: NP_253139.1
GI: 15599645
Sequence start: 4983552
Sequence End: 4984187
Sequence Length: 635
Gene Sequence: 
>PA4449
ATGCTGACCATCGCCTTGTCCAAGGGCCGGATTCTCGACGATACCCTGCCGCTGCTCGCAGCGGCGGGCATCGTACCGTCGGAGAACCCGGACAAGAGCCGCAAGCTGATCATCCCGACGTCCCTGTCCGATGTGCGCCTGCTCATCGTGCGCGCCACCGACGTGCCGACCTATGTCGAGCATGGCGCCGCCGATCTCGGCGTGGCCGGCAAGGACGTGCTGATGGAGTACGGCGGCCAGGGACTCTACGAACCGCTGGACCTGCGTATCGCCAACTGCAAGCTGATGACCGCCGGCGCCATTGGCGCGCCTGAACCCAAGGGACGCCTGCGGGTGGCCACCAAGTTCGTCAATGTCGCCAAGCGCTACTACGCCGAGCAGGGCCGCCAGGTCGACGTGATCAAGCTGTACGGCTCGATGGAGCTGGCGCCGCTGGTCGGTCTCGCCGACAAGATCATTGACGTCGTGGATACCGGCAATACCCTGCGCGCCAACGGCCTGGAGCCCCAGGAACTGATCGCCACGATCAGCTCGCGCCTGGTGGTCAACAAGGCCTCGATGAAGATGCAGCACGGTCGCATCCAGTCGCTGATCGATACCCTGCGCGACGCCGTCGAGGCGCGACACCGTCACTGA
Protein Properties
Protein Residues: 211
Protein Molecular Weight: 22.8 kDa
Protein Theoretical pI: 9.34
Hydropathicity (GRAVY score): 0.012
Charge at pH 7 (predicted): 3.92
Protein Sequence: 
>PA4449
MLTIALSKGRILDDTLPLLAAAGIVPSENPDKSRKLIIPTSLSDVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYGGQGLYEPLDLRIANCKLMTAGAIGAPEPKGRLRVATKFVNVAKRYYAEQGRQVDVIKLYGSMELAPLVGLADKIIDVVDTGNTLRANGLEPQELIATISSRLVVNKASMKMQHGRIQSLIDTLRDAVEARHRH
References
External Links:
Resource Link
Genome ID: PA4449
Entrez Gene ID: 880968
NCBI Protein ID: 15599645
General Reference: PaperBLAST - Find papers about PA4449 and its homologs